A5015563506- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Tryptophan and brain disorders
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Renal cell carcinoma treatment
- HIV-related health complications and treatments
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Pancreatic function and diabetes
- Diabetes Management and Research
- Hippo pathway signaling and YAP/TAZ
- Galectins and Cancer Biology
- Mechanisms of cancer metastasis
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Diabetes and associated disorders
- Renal and related cancers
- Peptidase Inhibition and Analysis
Guangzhou Medical University
2024-2025
The First Affiliated Hospital, Sun Yat-sen University
2021-2024
Sun Yat-sen University
2019-2024
Guangxi Medical University
2017
There is increasing evidence that circular RNAs (circRNAs) have significant regulatory roles in cancer development and progression; however, the expression patterns biological functions of circRNAs renal cell carcinoma (RCC) remain largely elusive. Bioinformatics methods were applied to screen for differentially expressed RCC. Analysis online microarray datasets our own patient cohort indicated circSDHC (hsa_circ_0015004) had a potential oncogenic role Subsequently, was measured RCC tissues...
Chemoresistance is one of the leading causes therapeutic failure in gastric cancer (GC) treatment. Recent studies have shown lncRNAs play pivotal roles regulating GC chemoresistance. Nanocarriers delivery small interfering RNAs (siRNAs) to silence cancer-related genes has become a novel approach treatment research. However, finding target and developing nanosystems capable selectively delivering siRNAs for disease remains challenge. In this study, lncRNA TMEM44-AS1 that related 5-FU...
Abstract Sunitinib resistance remains a serious challenge to the treatment of advanced and metastatic renal cell carcinoma (RCC), yet mechanisms underlying this are not fully understood. Here, we report that long noncoding RNA IGFL2-AS1 is driver therapy in RCC. was highly upregulated sunitinib-resistant RCC cells associated with poor prognosis patients clear (ccRCC) who received sunitinib therapy. enhanced TP53INP2 expression by competitively binding hnRNPC, multifunctional RNA-binding...
Abstract High lymphocyte infiltration and immunosuppression characterize the tumor microenvironment (TME) in renal cell carcinoma (RCC). There is an urgent need to elucidate how cells escape immune attack develop novel therapeutic targets enhance efficacy of checkpoint blockade (ICB) RCC. Overactivated IFN‐ γ ‐induced JAK/STAT signaling involves such TME, but underlying mechanisms remain elusive. Here, EH domain‐binding protein 1‐like 1 (EHBP1L1) identified as a crucial mediator...
Abstract Metastasis is the main cause of mortality in renal cell carcinoma (RCC). Circular RNAs (circRNAs) involvement RCC metastasis has been described, although underlying mechanisms remain unknown. We evaluated recurring lung-metastasis cases using patient-derived xenograft models and isolated a highly metastatic clone. CircSPIRE1 was identified as metastasis-inhibiting circRNA clinical cohort models. Mechanistically, circSPIRE1 suppressed mesenchymal state through regulating ELAV like...
Clear cell renal carcinoma (ccRCC) is a highly invasive and metastatic subtype of kidney malignancy correlated with metabolic reprogramming for adaptation to the tumor microenvironment comprising infiltrated immune cells immunomodulatory molecules. The role in (TME) their association abnormal fatty acids metabolism ccRCC remains poorly understood. RNA-seq clinical data KIRC from Cancer Genome Atlas (TCGA) E-MTAB-1980 ArrayExpress dataset. Nivolumab group Everolimus CheckMate 025 study,...
The tumor microenvironment (TME) in renal cell carcinomas (RCC) is marked by substantial immunosuppression and immune resistance despite having extensive T-cell infiltration. Elucidation of the mechanisms underlying evasion could help identify therapeutic strategies to boost efficacy checkpoint blockade (ICB) RCC. This study uncovered a mechanism wherein polyadenylate-binding protein PABPC1L modulates indoleamine 2,3-dioxygenase 1 (IDO1), prospective target for immunotherapy. was markedly...
Abstract Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal carcinoma (ccRCC). PVT1 is an oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism functioning ccRCC remains largely unknown. VHL deficiency-induced HIF2α accumulation one major factors for ccRCC. Here, we identified potential molecular promoting by stabilizing HIF2α. was significantly upregulated...
The aim of this study was to identify the ferroptosis induced tumor microenvironment (FeME) landscape in bladder cancer (BCa) for mRNA vaccine development and selecting suitable patients precision treatment.Gene expression profiles clinical information 1216 BCa were extracted from TCGA-BLCA, three GEO databases IMvigor210 cohort. We comprehensively established FeME samples based on 290 related genes (FRGs), systematically correlated these regulation patterns with TME cell-infiltrating...
The incidence of renal cell carcinoma (RCC) has increased in recent years. Metastatic RCC is common and remains a major cause mortality. A regulatory role for circular RNAs (circRNAs) the occurrence progression been identified, but their function, molecular mechanisms, potential clinical applications remain poorly understood.High-throughput RNA sequencing was used to explore differential expression circRNAs related pathways patients. Transwell CCK-8 assays were assess function...
This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-024-03113-9.
Abstract Background Recent studies have identified that circular RNAs (circRNAs) an important role in cancer via their well-recognized sponge effect on miRNAs, which regulates a large variety of cancer-related genes. However, only few circRNAs been well-studied renal cell carcinoma (RCC) and regulatory function remains largely elusive. Methods Bioinformatics approaches were used to characterize the differentially expressed our own circRNA-sequencing dataset, as well two public circRNA...
Aberrant expression of circular RNAs (circRNAs) has been reported to play an important biological regulatory role in gastric cancer (GC). For the purpose silencing cancer-related genes, a new approach for treatment using nanocarriers deliver siRNA proposed. In this study, abundantly expressed circMAP2K2 (hsa_circRNA_102415) is identified GC cells. CircMAP2K2 regulates PCBP1/GPX1 axis through proteasome-mediated degradation, which further mediates activation...
Immune checkpoint inhibitor (ICI) therapy improves the survival of patients with advanced bladder cancer (BLCA); however, its overall effectiveness is limited, and many still develop immunotherapy resistance. The leucine-rich repeat fibronectin type-III domain-containing protein (LRFN) family has previously been implicated in regulating brain dysfunction; mechanisms underlying effect LRFN2 on tumor microenvironment (TME) remain unclear.Here we combined bulk RNA sequencing, single-cell...
Clear cell Renal Cell Carcinoma (ccRCC) is a highly heterogeneous disease, making it challenging to predict prognosis and therapy efficacy. In this study, we aimed explore the role of 5-methylcytosine (m5C) RNA modification in ccRCC its potential as predictor for response overall survival (OS). We established novel modification-related gene index (M5CRMRGI) studied effect on tumor microenvironment (TME) using single-cell sequencing data in-depth analysis, verified spatial data. Our results...
<div>Abstract<p>Sunitinib resistance remains a serious challenge to the treatment of advanced and metastatic renal cell carcinoma (RCC), yet mechanisms underlying this are not fully understood. Here, we report that long noncoding RNA <i>IGFL2-AS1</i> is driver therapy in RCC. was highly upregulated sunitinib-resistant RCC cells associated with poor prognosis patients clear (ccRCC) who received sunitinib therapy. enhanced TP53INP2 expression by competitively binding...
Insulin-producing cells (IPCs) derived from a patient's own stem offer great potential for autologous transplantation in diabetic patients. However, the limited survival of engrafted remains bottleneck application this strategy. The present study aimed to investigate whether nanoparticle-based magnetic resonance (MR) tracking can be used detect loss grafted cell-derived IPCs sensitive and timely manner monkey model. Pancreatic progenitor (PPCs) were isolated monkeys labeled with...
<div>Abstract<p>The tumor microenvironment (TME) in renal cell carcinomas (RCC) is marked by substantial immunosuppression and immune resistance despite having extensive T-cell infiltration. Elucidation of the mechanisms underlying evasion could help identify therapeutic strategies to boost efficacy checkpoint blockade (ICB) RCC. This study uncovered a mechanism wherein polyadenylate-binding protein PABPC1L modulates indoleamine 2,3-dioxygenase 1 (IDO1), prospective target for...
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