A5101807195- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Renal cell carcinoma treatment
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Urinary and Genital Oncology Studies
- Kidney Stones and Urolithiasis Treatments
- Urological Disorders and Treatments
- Urinary Tract Infections Management
- Urologic and reproductive health conditions
- Sarcoma Diagnosis and Treatment
- Circular RNAs in diseases
- Sepsis Diagnosis and Treatment
- Soft tissue tumor case studies
- Nutritional Studies and Diet
- Diet, Metabolism, and Disease
- Pediatric Urology and Nephrology Studies
- Pluripotent Stem Cells Research
- Inflammatory Biomarkers in Disease Prognosis
- Bone Tumor Diagnosis and Treatments
- Cancer, Lipids, and Metabolism
- Retinal Imaging and Analysis
- Tissue Engineering and Regenerative Medicine
Binzhou University
2025
Binzhou Medical University
2025
Guangzhou Medical University
2022-2024
Jiangnan University
2024
Second Affiliated Hospital of Guangzhou Medical University
2022-2024
The First Affiliated Hospital, Sun Yat-sen University
2017-2022
Sun Yat-sen University
2017-2022
Qingdao University
2019
Hong Kong Baptist University
2006
Chongqing University
2006
Abstract Increasing evidences show the clinical significance of interaction between hypoxia and immune in clear cell renal carcinoma (ccRCC) microenvironment. However, reliable prognostic signatures based on a combination have not been well established. Moreover, many studies only used RNA-seq profiles to screen prognosis feature ccRCC. Presently, there is no comprehensive analysis multiomics data mine better one. Thus, we try get it. First, t-SNE ssGSEA were establish tumor subtypes related...
Abstract Background Circular RNAs (circRNAs) have been indicated as potentially critical mediators in various types of tumor progression, generally acting microRNA (miRNA) sponges to regulate downstream gene expression. However, the aberrant expression profile and dysfunction circRNAs human clear cell renal carcinoma (ccRCC) need be further investigated. This study mined key prognostic elucidates potential role molecular mechanism regulating proliferation metastasis ccRCC. Methods circCHST15...
Abstract Long noncoding RNAs (lncRNAs) have been reported to exert important roles in tumors, including clear cell renal carcinoma (ccRCC). PVT1 is an oncogenic lncRNA which has critical effects on onset and development of various cancers, however, the underlying mechanism functioning ccRCC remains largely unknown. VHL deficiency-induced HIF2α accumulation one major factors for ccRCC. Here, we identified potential molecular promoting by stabilizing HIF2α. was significantly upregulated...
The aim of this study was to identify the ferroptosis induced tumor microenvironment (FeME) landscape in bladder cancer (BCa) for mRNA vaccine development and selecting suitable patients precision treatment.Gene expression profiles clinical information 1216 BCa were extracted from TCGA-BLCA, three GEO databases IMvigor210 cohort. We comprehensively established FeME samples based on 290 related genes (FRGs), systematically correlated these regulation patterns with TME cell-infiltrating...
ABSTRACT Changes in hydroxyproline metabolism are reported to promote tumorigenesis. HOGA1 is a useful marker for diagnosing primary hyperoxaluria 3, catalysing the final step of mitochondrial from 4‐hydroxy‐2‐oxoglutarate (HOG) glyoxylate and pyruvate; however, its specific mechanism RCC remains unclear. This study investigated role pathogenesis ccRCC. The results showed that was decreased significantly tumour tissues, with this low expression associated poor prognosis patients QTL mapping...
The vascular tree of the retina is likely most representative and stable feature for eye fundus images in registration. Based on reconstructed tree, we propose an elastic matching algorithm to register pairs images. identified vessels are thinned approximated using short line segments equal length that results a set elements. elements corresponding one elastically deformed optimally match another with guide energy function finally establish pixel relationship between both trees. mapped...
Urine-derived stem cells (USCs) have been widely researched as a novel cell source for therapy, but their immunomodulatory characteristics remain to be investigated. This study aimed characterize the properties of human USCs.Human USCs were isolated from fresh voiding urine samples healthy male donors and expanded. Their surface markers characterized by flow cytometry analysis telomerase activities several clones determined. The immunosuppressive potential was evaluated performing mixed...
Most localized human renal clear cell carcinoma (ccRCC)-related deaths result from cancer recurrence and metastasis. However, the precise molecular mechanisms largely remain unknown. In recent years, an increasing number of long noncoding RNAs (lncRNAs) have been shown to be vital regulators tumorigenesis. this study, we characterized a lncRNA DUXAP9 upregulation was analyzed by quantitative real-time PCR in 112 pairs ccRCC tumor tissues compared with adjacent normal tissues. Kaplan–Meier...
Abstract Background Active surveillance (AS) with delayed intervention has gained acceptance as a management strategy for small renal masses (SRMs). However, during AS, there is risk of tumor growth. Thus, we aim to investigate whether growth in patients SRMs leads progress. Methods In this study, enrolled 16,070 from the Surveillance, Epidemiology, and End Results database T1a cell carcinoma (RCC) between 2004 2017. The were divided into three groups: 10,526 partial nephrectomy (PN) group,...
Objectives: To investigate the factors associated with systemic infection after percutaneous nephrolithotomy (PCNL) and establish a predictive model to provide theoretical basis for prevention of inflammatory response syndrome (SIRS) urosepsis correlate nephrostomy. Methods: Patients received PCNL between January 2016 December 2020 were retrospectively enrolled. All patients categorized into groups according postoperative SIRS status. Single factor analysis multivariate logistic regression...
Clear cell Renal Cell Carcinoma (ccRCC) is a highly heterogeneous disease, making it challenging to predict prognosis and therapy efficacy. In this study, we aimed explore the role of 5-methylcytosine (m5C) RNA modification in ccRCC its potential as predictor for response overall survival (OS). We established novel modification-related gene index (M5CRMRGI) studied effect on tumor microenvironment (TME) using single-cell sequencing data in-depth analysis, verified spatial data. Our results...
Immune checkpoint inhibitor (ICI) treatment has been used to treat advanced urothelial cancer. Molecular markers might improve risk stratification and prediction of ICI benefit for cancer patients. We analyzed 406 cases bladder from The Cancer Genome Atlas (TCGA) data set identified 161 messenger RNAs (mRNAs) as differentially expressed immunity genes (DEIGs). Using the LASSO Cox regression model, an eight-mRNA-based signature was built. validated prognostic predictive accuracy this...
Introduction Main renal artery clamping and selective arterial are two conventional devascularization methods for robot-assisted partial nephrectomy (RAPN) (1, 2). Decreasing warm ischemic (WI) time (3, 4) improving clear surgical visualization (5) the main surgically modifiable factors RAPN, especially in large complex cancer (6). In this study, we described our technique, focusing on gradual segmental unclamping patients with tumors. Material Two (R.E.N.A.L score 10 11) underwent RAPN...
Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare renal composed cells. In this study, we report case MESTK, which was pathologically benign but complicated with vein inferior vena cava thrombus. The 50-year-old female patie nt admitted to hospital for mass on left kidney. Computed tomography showed 32 mm×18 mm slight delayed enhancement in sinus, neoplastic thrombus detected cava. A preoperative diagnosis leiomyoma made by needle biopsy laparoscopic radical nephrectomy...
Immunotherapy with checkpoint inhibitors, such as PD-1/PD-L1 blockage, is becoming standard of practice for an increasing number cancer types. However, the response rate only 10%-40%. Thus, identifying biomarkers that could accurately predict ICI-therapy critically important. We downloaded somatic mutation data 46,697 patients and tumor-infiltrating immune cells levels 11070 patients, then combined TP53 BRAF status into a biomarker model found ability TP53/BRAF more powerful than some past...
This study aims to investigate the predictive performance of machine learning in predicting occurrence systemic inflammatory response syndrome (SIRS) and urosepsis after percutaneous nephrolithotomy (PCNL).
The present study aimed to explore the associations between Mediterranean diet trajectories (MDTs) and cardiovascular disease-related risk factors in Chinese adults.
Factors related to coagulation regulation are closely angiogenesis, epithelial-mesenchymal transition, tumor proliferation and metastasis, immune microenvironment remodeling in tumors. To date, there no quantitative indicators of associated with urothelial cancer. We classified cancer into high low subtypes by screening for procoagulant-related molecular features screened out relevant genes representing the state carcinoma. Tumors increased procoagulant gene expression were consistently...
Objective: To observe the effect of Dioscorea pills on immunity mice with ovarian cancer after chemotherapy and its mechanism action.Methods: BALB/C were randomly divided into blank group, model group plus TCM (Traditional Chinese Medicine) 20 in each group.Except 60 other groups subcutaneously injected SKOV-3 cell suspension at right buttock to build a tumor-bearing mouse model.After tumor formation, intraperitoneally Docetaxel.Next day, was given by gavage, while three equal quantity...
To explore whether opening the external urethral orifice in coronal sulcus can reduce incidence of epididymitis after operating on hypospadias with prostatic utricle cyst (PUC) connecting to vas deferens. Group A consisted 3 patients severe and PUC undergoing cystostomy, correction urethroplasty, along relocation urethra sulcus. B 4 having initial repaired meatus orthotopic position glans, presenting multiple surgery unsuccessful conservative treatment. MR confirmed that all had underwent...
Objective To investigate the clinical manifestations, imaging and pathological features treatment prognosis of primary renal sarcoma in adults. Methods A retrospective analysis was performed on data 48 patients with from January 2009 to December 2018 first affiliated hospital cancer center Sun Yat-Sen university. There were 30 males 18 females. Their aged ranged 27 76 yrs an average age 50 yrs. A total 24 presented lumbar abdominal pain. Abdominal mass found 2 cases. Gross hematuria...
Abstract OBJECTIVE : To explore whether opening the external urethral orifice in coronal sulcus can reduce incidence of epididymitis after operating on hypospadias with a prostatic cyst connected to vas deferens. MATERIALS AND METHODS Three patients (group A) (average age = 3.3 years old) severe and underwent cystostomy, correction urethroplasty, along relocation urethra. Group B consisted 4 6.9 presenting surgery Unsuccessful conservative treatment. Patients dilatation catheterization,...