A5078095647- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Urinary and Genital Oncology Studies
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Circular RNAs in diseases
- Ureteral procedures and complications
- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Urinary Bladder and Prostate Research
- Adrenal and Paraganglionic Tumors
- Renal and related cancers
- Angiogenesis and VEGF in Cancer
- Prostate Cancer Diagnosis and Treatment
- Urinary Tract Infections Management
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Respiratory Support and Mechanisms
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Radiomics and Machine Learning in Medical Imaging
- Urological Disorders and Treatments
- Protease and Inhibitor Mechanisms
- Bone Tumor Diagnosis and Treatments
Sun Yat-sen University
2015-2024
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Human bone marrow mesenchymal stem cells (hBMSCs) are implicated in cancer initiation and metastasis, sometimes by releasing exosomes that mediate cell communication delivering microRNAs (miRNAs). This study aimed to investigate the physiological mechanisms which exosomal miR-205 derived from hBMSCs may modulate growth of prostate cells.Microarray-based gene expression profiling was adopted identify differentially expressed genes regulatory miRNAs, identified candidates RHPN2 as focus. Then...
Abstract Prostate cancer (PCa) patients commonly present with osteoblastic‐type bone metastasis. Exosomes derived from tumor cells possess biological significance and can mediate intercellular communication in the microenvironment. Long noncoding RNA (lncRNA) nuclear‐enriched abundant transcript 1 (NEAT1) is also implicated stability tumorigenesis development of PCa, but underlying mechanism remains elusive. Hence, current study set out to investigate physiological mechanisms by which...
Aggressive tumor cells can form perfusable networks that mimic normal vasculature and enhance growth metastasis. A number of molecular players have been implicated in such vasculogenic mimicry, among them the receptor tyrosine kinase EphA2, which is aberrantly expressed aggressive tumors. Here we study role regulation EphA2 mimicry prostate cancer where this phenomenon still poorly understood.Vasculogenic was characterized by tubules whose cellular lining negative for endothelial cell marker...
Abstract Circular RNAs (circRNAs) play critical roles in clear cell renal carcinoma (ccRCC). However, their involvement sunitinib resistance remains largely unknown. Herein, we identified a novel circRNA, named circME1, which contributes to development ccRCC. CircME1 also promoted proliferation, migration, and invasion of ccRCC cells. Further mechanism analysis showed that circME1 interacted with U1 snRNP at the promoter its parental gene ME1, thereby upregulating expression enhancing...
Objectives: To investigate the factors associated with systemic infection after percutaneous nephrolithotomy (PCNL) and establish a predictive model to provide theoretical basis for prevention of inflammatory response syndrome (SIRS) urosepsis correlate nephrostomy. Methods: Patients received PCNL between January 2016 December 2020 were retrospectively enrolled. All patients categorized into groups according postoperative SIRS status. Single factor analysis multivariate logistic regression...
Preoperative diagnosis of urinary infection stones is difficult, and accurate detection stone composition can only be performed ex vivo. To provide guidance for better perioperative management postoperative prevention stones, we developed a machine learning model preoperative identification in The clinical data patients with urolithiasis who underwent surgery our hospital from January 2011 to December 2015 2017 2021 were retrospectively analyzed. A total 2565 included the study, 1168...
Background Desmocollin 3 (DSC3), a member of the cadherin gene superfamily, is associated with pathogenesis some cancers, but its role in prostate cancer (PCa) remains largely unknown. Methods DSC3 expression level available PCa microarray dataset was examined using Oncomine database. transcript cell line panel and an independent tissue cohort (n = 52) estimated by quantitative PCR (Q-PCR). Epigenetic status promoter investigated uploading three (ENCODE Infinium 450K array data two...
Background The efficacy of docetaxel-based chemotherapy is limited by the development drug resistance. Recent studies demonstrated anti-programmed death-1 (PD-1)/programmed cell death ligand-1 (PD-L1) immunotherapies in metastatic prostate cancer. ataxia telangiectasia mutation (ATM) protein plays a crucial role maintaining genome stability and function mitosis. Here, we aimed to determine whether PD-1/PD-L1 signaling contributes resistance DTX elucidate mechanism underlying DTX-induced...
Abstract Protein kinase C epsilon (PKCε), an oncogene overexpressed in several human cancers, is involved cell proliferation, migration, invasion, and survival. However, its roles clear renal carcinoma (RCC) are unclear. This study aimed to investigate the functions of PKCε RCC, especially determine possibility using it as a therapeutic target. By immunohistochemistry, we found that expression was up-regulated RCCs associated with tumor Fuhrman grade T stage RCCs. Clone formation, wound...
The aim of the present study was to investigate associations between vasculogenic mimicry (VM) and zinc finger E-box binding homeobox 1 (ZEB1) in bladder cancer. VM structure ZEB1 expression were analyzed by cluster differentiation 34/periodic acid Schiff (PAS) double staining immunohistochemical 135 specimens from patients with cancer, a further 12 normal tissues. Three-dimensional (3-D) culture used detect formation transitional cancer cell lines UM-UC-3 J82, immortalized human epithelium...
Prophylactic intravesical chemotherapy can decrease bladder cancer recurrence rate after nephroureterectomy for upper tract urothelial carcinoma. We aimed to compare the effect of different prophylactic regimens in recurrence-free survival. From 2000 2016, a total 270 patients treated with radical at both institutions were enrolled. Patients divided into 3 groups: multiple-instillation group, single-instillation and no-instillation group. Univariable multivariable analyses Cox regression...
Abstract Group 3 innate lymphoid cells (ILC3s) represent a new population in immune regulation, yet their role lupus nephritis (LN) remains elusive. In the present work, systemic increases ILC3s, particularly kidney, are observed to correlate strongly with disease severity both human and murine LN. Using MRL/ lpr mice nephrotoxic serum‐induced LN model, this study demonstrates that ILC3s accumulated kidney migrate predominantly from intestine. Furthermore, intestinal accelerate progression,...
Mixed epithelial and stromal tumor of the kidney (MESTK) is a rare renal composed cells. In this study, we report case MESTK, which was pathologically benign but complicated with vein inferior vena cava thrombus. The 50-year-old female patie nt admitted to hospital for mass on left kidney. Computed tomography showed 32 mm×18 mm slight delayed enhancement in sinus, neoplastic thrombus detected cava. A preoperative diagnosis leiomyoma made by needle biopsy laparoscopic radical nephrectomy...
Background: Numerous studies have substantiated the association between aging and progression of malignant tumors in humans, notably prostate cancer (PCa).Nevertheless, to best our knowledge, no comprehensively elucidated intricate characteristics microenvironment (AME) PCa.Methods: AME regulatory patterns were determined using NMF algorithm.Then an ageing index (AMI) was constructed, with excellent prognostic immunotherapy prediction ability, its' clinical relevance surveyed through spatial...
The aim of the present study was to predict key genes and proteins associated with complex regional pain syndrome (CRPS) using bioinformatics analysis. gene expression profiling microarray data, GSE47603, which included peripheral blood samples from 4 patients CRPS 5 healthy controls, obtained Gene Expression Omnibus (GEO) database. differentially expressed (DEGs) in compared controls were identified GEO2R online tool. Functional enrichment analysis then performed Database for Annotation...
Background: Prostate cancer is the second most common in men. It urgent to develop a genetic classification for prostate cancer. We aimed establish basis of typing.Methods: used four series data. The Cancer Genome Atlas (TCGA) RNA-Seq data were train classifier. Three subgroups based on classifier tested whether have significant differences clinical other three sets classified by and validated with respective data.Results: had 183 genes. subtype 1 (PCS1) was characterized high expression...
BACKGROUND: Amplified in breast cancer 1 (AIB1) is a candidate oncogene human cancer, which has been identified to be amplified and overexpressed several types of other cancers. Abnormalities AIB1 its clinical/prognostic significance, however, upper tract urothelial car cinoma (UTUC) remain unclear. OBJECTIVE: To explore what role plays carcinoma. METHODS: The expression was analyzed using immunohistochemical staining 133 UTUC patients. Overall, specific recurrence-free survival rates (OS,...