A5101631459- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Receptor Mechanisms and Signaling
- Plant Stress Responses and Tolerance
- PI3K/AKT/mTOR signaling in cancer
- Neurotransmitter Receptor Influence on Behavior
- Plant Molecular Biology Research
- Virus-based gene therapy research
- Protein Degradation and Inhibitors
- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- Immunotherapy and Immune Responses
- Liver physiology and pathology
- Cancer-related gene regulation
- RNA Research and Splicing
- Plant Parasitism and Resistance
- NF-κB Signaling Pathways
- Cancer, Hypoxia, and Metabolism
- Wnt/β-catenin signaling in development and cancer
- Bioactive Compounds and Antitumor Agents
- RNA Interference and Gene Delivery
- Biochemical and Structural Characterization
- Histone Deacetylase Inhibitors Research
- Cancer therapeutics and mechanisms
- CRISPR and Genetic Engineering
Sun Yat-sen University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
China Medical University
2020-2022
Guangdong Medical College
2011-2020
Chinese Academy of Sciences
2017-2020
Shanghai Institute of Organic Chemistry
2020
State Ethnic Affairs Commission
2020
Southwest Minzu University
2019-2020
Tongji Hospital
2008-2017
Huazhong University of Science and Technology
2008-2017
Abstract Intestinal permeability plays a critical role in the etiopathogenesis of ulcerative colitis. Defensins, including porcine β-defensin (pBD)2, are crucial antimicrobial peptides for gut protection owing to their antibacterial and immunomodulatory activities. The purpose this study was investigate protective effects pBD2 on mucosal injury disruption epithelial barrier during pathological process dextran sodium sulfate (DSS)–induced mechanism were evaluated both using DSS-induced...
Increasing CO2 concentrations ([CO2]) have the potential to disrupt plant–pathogen interactions in natural and agricultural ecosystems, but research this area has often produced conflicting results. Variations phytohormone salicylic acid (SA) jasmonic (JA) signalling could be associated with variations responses of pathogens plants grown under elevated [CO2]. In study, between tomato three different infection strategies were compared. Elevated [CO2] generally favoured SA biosynthesis...
Persistent HPV infection is recognized as the main etiologic factor for cervical cancer. expresses oncoproteins E6 and E7, both of which play key roles in maintaining viral promoting carcinogenesis. While siRNA-mediated targeting E7 transcripts temporarily induces apoptosis HPV-positive cells, it does not eliminate DNA within host genome, can harbor escape mutants. Here, we demonstrated that specifically with transcription activator-like effector nucleases (TALENs) apoptosis, inhibits...
Serine/arginine-rich (SR) proteins are important splicing factors which play significant roles in spliceosome assembly and regulation. However, little is known regarding their biological functions plants. Here, we analyzed the phenotypes of mutants upon depleting different subfamilies Arabidopsis SR proteins. We found that loss SC35 SC35-like (SCL) cause pleiotropic changes plant morphology development, including serrated leaves, late flowering, shorter roots abnormal silique phyllotaxy....
Plant responses to elevated CO₂ and high temperature are critically regulated through a complex network of phytohormones redox homeostasis. However, the involvement abscisic acid (ABA) in plant adaptation heat stress under conditions has not been thoroughly studied. This study investigated interactive effects (800 μmol·mol(-1) ) (42 °C for 24 h) on endogenous level ABA cellular state two genotypes tomato with different biosynthesis capacities. Heat significantly decreased maximum...
We investigated the role of 24-epibrassinolide (EBR) in amelioration phenanthrene (PHE) stress tomato (Solanum lycopersicum L.). Exposure to PHE (300 μM) significantly decreased shoot and root length (19 16 %, respectively), fresh mass (35 43 contents chlorophyll a (26 %), b (27 %) carotenoids (18 plants. In addition, increased malondialdehyde (MDA) content (57 activity secondary metabolism related enzymes glutathione-S-transferase (GST), glucose-6-phosphate dehydrogenase (G6PDH), shikimate...
Antimicrobial peptides are molecules of innate immunity. Cathelicidin-BF is the first cathelicidin peptide found in reptiles. However, immunoregulatory and epithelial barrier protective properties C-BF have not been reported. Inflammatory bowel diseases, including ulcerative colitis Crohn's disease, can lead to colon cancer, third most common malignant tumor. The objective develop new cathelicidin-BF as a therapeutic patients colitis. morphology epithelium was observed by H&E staining;...
E-cadherin is a key cell-to-cell adhesion molecule associated with the invasion and metastasis of tumor cells; however, molecular mechanisms are not entirely understood. In this study, we investigated whether downregulation by E-cadherin-specific small intefering RNA (siRNA) was able to promote malignant phenotypes prostate cancer cells through upregulating metastasis-associated gene 1 (MTA1) in vitro. The expression levels human paired adenocarcinoma cell lines, PC-3M-2B4 (2B4) PC-3M-1E8...
Abstract Background Mesenchymal stem cells (MSCs) have been considered to be the attractive vehicles for delivering therapeutic agents toward various tumor diseases. This study was explore distribution pattern, kinetic delivery of adenovirus, and efficacy MSC loading E1A mutant conditionally replicative adenovirus Adv-Stat3(-) which selectively replicated expressed high levels anti-sense Stat3 complementary DNA in breast cancer melanoma cells. Methods We assessed release ability (CRAd) from...
A negative influence of IL-4 on the IL-2-induced B cell proliferation and differentiation has recently been reported. In this study, we have further investigated a role human tonsillar IL-2R expression. enhanced Staphylococcus aureus Cowan 1 strain (SAC)-induced proliferation, reaching peak day 3. However, from 4, inhibited proliferation. cross-linking density 125I-IL-2-binding protein at low affinity binding condition (2 nM 125I-IL-2) in SAC-activated cells. blocked enhancement proteins...