A5013876616- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Cancer-related molecular mechanisms research
- Cardiovascular Disease and Adiposity
- Adipose Tissue and Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Atherosclerosis and Cardiovascular Diseases
- Heart Rate Variability and Autonomic Control
- Biological and pharmacological studies of plants
- Saffron Plant Research Studies
- Clostridium difficile and Clostridium perfringens research
- Redox biology and oxidative stress
- Cardiac Fibrosis and Remodeling
- Fecal contamination and water quality
- Cancer, Lipids, and Metabolism
- Nitric Oxide and Endothelin Effects
- Immunotherapy and Immune Responses
- Bee Products Chemical Analysis
- Liver Disease Diagnosis and Treatment
- interferon and immune responses
- Animal Nutrition and Physiology
- Signaling Pathways in Disease
- Infant Nutrition and Health
- Gut microbiota and health
- Acupuncture Treatment Research Studies
Zhejiang Chinese Medical University
2019-2023
Zhejiang University
2013-2015
This study hypothesized that the gut microbial populations, intestinal morphology, and cytokine production are differentially altered in 2 different pig breeds, namely, Chinese native Jinhua pigs European Landrace pigs, after orally challenge with enterotoxigenic Escherichia coli (ETEC) K88. A total of 12 were allocated to either nonchallenged or challenged groups (6 per group). The administered ETEC K88, their counterparts given sterile Luria-Bertani broth. Selected mRNA expression tight...
Antimicrobial peptides are molecules of innate immunity. Cathelicidin-BF is the first cathelicidin peptide found in reptiles. However, immunoregulatory and epithelial barrier protective properties C-BF have not been reported. Inflammatory bowel diseases, including ulcerative colitis Crohn's disease, can lead to colon cancer, third most common malignant tumor. The objective develop new cathelicidin-BF as a therapeutic patients colitis. morphology epithelium was observed by H&E staining;...
Casein glycomacropeptide (CGMP) is a bioactive peptide derived from milk with multiple functions. This study was aimed at evaluating the effects of CGMP as potential feed additive on growth performance, intestinal morphology, barrier permeability and inflammatory responses Escherichia coli K88 (E. K88) challenged piglets. Eighteen weaning piglets were randomly assigned to three groups. Control group received basal diet, treated diet supplemented 1% powder. The trail lasted for 12 days,...
Atherosclerosis is a major contributor to cardiovascular events, however, its molecular mechanism remains poorly known. Animal models of atherosclerosis can be valuable tool provide insights into the etiology, pathophysiology, and complications atherosclerosis. In particular, Tibetan minipigs are feasible model for studying diet-related metabolic atherosclerotic diseases.We used vascular transcriptomics identify differentially expressed genes (DEGs) in high fat/cholesterol (HFC) diet-fed...
Among royal jelly's (RJ) various biological activities, its possible antihypertension and vasorelaxation effects deserve particular attention, but the underlying mechanisms of action remain unclear. Therefore, this study used spontaneously hypertensive rats (SHR) hypertension model isolated rabbit thoracic aorta rings to explore hypotension RJ. Rats were divided into following groups (n = 6): WKY-control group, SHR-control SHR-RJ group. group was received 1 g/kg RJ via oral administration...
Vasodilatory therapy plays an important role in the treatment of cardiovascular diseases, especially hypertension and coronary heart disease. Previous research found that Guanxinning tablet (GXNT), a traditional Chinese compound preparation composed Salvia miltiorrhiza (Danshen) Ligusticum chuanxiong (Chuanxiong), increase blood flow arteries, but whether vasodilation this effect remains unclear. Here, we GXNT significantly alleviated vasoconstriction isolated rabbit thoracic aorta induced...
Myocardial hypertrophy may lead to heart failure and sudden death. As traditional Chinese medicine, Guanxinning tablets (GXN) have significant pharmacological effects in the prevention treatment of cardiovascular diseases. However, anti-cardiac efficacy GXN its mechanism action are still unclear. Therefore, we established a rat model isolated primary cardiomyocytes neonatal observe protective effect on intervention myocardial cell hypertrophy, explore possible preventing treating...
Objective To investigate the role of Sirt1 in visceral adipose tissue Tibetan mini-pigs with obesity and insulin resistance induced by high fat/cholesterol diet. Methods Twelve male were divided into 2 groups randomly: normal control (NC) group, high-fat/cholesterol (HFC) diet 6 each group. After 16 weeks modeling, fasting body weight mass index (BMI) measured. Total cholesterol (TC), low-density lipoprotein (LDL-C) high-density (HDL-C) measured anterior venous blood, atherosclerosis (AI)...