A5101396739- Spectroscopy and Quantum Chemical Studies
- Lipid Membrane Structure and Behavior
- Receptor Mechanisms and Signaling
- Photoreceptor and optogenetics research
- Water resources management and optimization
- Neurotransmitter Receptor Influence on Behavior
- Electrocatalysts for Energy Conversion
- Polymer Surface Interaction Studies
- Metabolism and Genetic Disorders
- Molecular Junctions and Nanostructures
- Analytical Chemistry and Sensors
- Advanced Algorithms and Applications
- Electric Power System Optimization
- Photosynthetic Processes and Mechanisms
- Neuroscience and Neuropharmacology Research
- Advanced Sensor and Control Systems
- Reservoir Engineering and Simulation Methods
- Antimicrobial Peptides and Activities
- Water Quality Monitoring Technologies
- Water Systems and Optimization
- Antenna Design and Optimization
- Peroxisome Proliferator-Activated Receptors
- Hydrology and Watershed Management Studies
- Chemical and Physical Properties in Aqueous Solutions
- Cellular transport and secretion
University of Michigan
2019-2025
North China University of Water Resources and Electric Power
2011-2024
North China University of Technology
2023
Henan Forestry Vocational College
2023
Tianjin University of Traditional Chinese Medicine
2023
Chinese Academy of Sciences
2016
Shanghai Astronomical Observatory
2016
Nanfang Hospital
2015
Southern Medical University
2015
Columbia University
2005-2009
Functional crosstalk between G protein-coupled receptors in a homo- or heterodimeric assembly likely involves conformational changes at the dimer interface, but nature of this interface is not yet established, and dynamic have been identified. We mapped homodimer dopamine D2 receptor over entire length fourth transmembrane segment (TM4) by crosslinking substituted cysteines. Their susceptibilities to are differentially altered presence agonists inverse agonists. The TM4 agonist-bound...
Graphene-based biosensors have attracted considerable attention due to their advantages of label-free detection and high sensitivity. Many such utilize noncovalent van der Waals force attach proteins onto graphene surface while preserving graphene's conductivity. Maintaining the protein structure without denaturation/substantial conformational change controlling proper orientation on are critical for biosensing applications these fabricated with graphene. Based knowledge we obtained from our...
A systematic method combining SFG vibrational spectroscopy, isotope labeling, spectra calculation and computer simulation was developed to elucidate interfacial structures of proteins.
Polymeric zwitterions exhibit exceptional fouling resistance through the formation of a strongly hydrated surface immobilized water molecules. While being extensively tested for their performance in biomedical, membrane, and, to lesser extent, marine environments, few studies have investigated how molecular design zwitterion may enhance its performance. Furthermore, while theories antifouling mechanisms exist molecular-scale foulant species (e.g., proteins and small molecules), it remains...
Recently, a super uranyl binding protein (SUP) was developed, which exhibits excellent sensitivity/selectivity to bind ions. It can be immobilized onto surface in sensing devices detect Here, sum frequency generation (SFG) vibrational spectroscopy applied probe the interfacial structures of surface-immobilized SUP. The collected SFG spectra were compared calculated orientation-dependent SUP using one-excitonic Hamiltonian approach based on crystal deduce most likely orientation(s)....
Reservoir flood control scheduling is a challenging optimization task, particularly due to the complexity of various constraints. This paper proposes an innovative algorithm design approach address this challenge. Combining basic walrus with adaptive ε-constraint method and introducing SPM chaotic mapping for population initialization, spiral search strategy, local enhancement strategy based on Cauchy mutation reverse learning significantly enhances algorithm's performance. On basis,...
Biofouling poses a significant issue in the maritime industry, where attachment of biofoulants to ships greatly affects operational costs, surface durability, and marine pollution. Barnacles barnacle proteins are widely used as models study biofouling mechanisms. With combined situ experimental simulation approach, this elucidated molecular interaction mechanisms between cement-derived peptides (BCPs) polymer. The results showed that peptide-charged segment plays role interfacial...
Polymers are widely used for many applications ranging from biomedical materials, marine antifouling coatings, membranes biomolecule separation, to substrates enzyme molecules biosensing. For such applications, it is important understand molecular interactions between biological and polymer materials in situ real time. Such understanding provides vital knowledge manipulate molecule–polymer optimize surface structures improve performance. In this research, sum frequency generation (SFG)...
The colonization ability of bacteria on biomaterial surfaces is influenced by the morphology and nanotopography biomaterial. However, interactions between bacterial biomaterials have not yet been completely elucidated. In this article, we quantitatively characterized to illuminate integrated effects polyethylene terephthalate (PET) nanopillar arrays cells with different shapes. Our results demonstrated that interaction interpillar spacing diameter impacted number adhered PET substrates....
There is significant interest in the development of antimicrobial compounds to overcome increasing bacterial resistance conventional antibiotics. Studies have shown that naturally occurring and de novo-designed peptides could be promising candidates. MSI-594 a synthetic linear, cationic peptide has been reported exhibit broad spectrum activities. Investigation into how disrupts cell membrane important for better understanding details this (AMP)'s action against cells. In study, we used two...
SFG spectra analyzed by the developed Hamiltonian method show that adsorbed BSA molecules on silicone oil are dimers. On treatment with dithiothreitol, some dimers dissociate, resulting in 60% dimer and 40% monomer surface.
Abstract The development of new strategies for the operation existing dams is essential restoring ecosystems that have already been affected by construction and current regulation these dams. assessment environmental flows (EFs) significant in guiding such strategic dam operations. However, most methods just focus on one species or guild without simultaneously considering interactions with other aquatic organisms. This study proposes an innovative method to determine comprehensive (CEFs)...
Lipopolysaccharide (LPS) is a component of the outer membrane Gram-negative bacteria. Recently, label-free immobilized antimicrobial peptide (AMP) surface plasmon resonance platform was developed to successfully distinguish LPS from multiple bacterial strains. Among tested AMPs, SMAP29 exhibited excellent affinity with and has two independent LPS-binding sites located at termini peptide. In this study, sum frequency generation vibrational spectroscopy applied investigate molecular...
Abstract The operation of reservoir flood control is a multifaceted engineering issue characterized by complexity, several stages, nonlinearity, and many dimensions. It involves various intricate constraints interrelated decision variables. Traditional algorithms tend to be slow prone local optima when solving optimization problems for in groups. In recent years, with the introduction technologies, more intelligent have been applied optimize scheduling years. However, this remains...
Separating adhesives from substrates is important for recycling metals and polymer materials used in a variety of applications such as food packaging electronics. A proof-of-concept self-assembled debonding layer on demand developed this research. The applied to silica surface three steps. These steps were characterized with sum frequency generation (SFG) vibrational spectroscopy, X-ray photoelectron spectroscopy (XPS), contact angle goniometry. SFG data shows characteristic signals each...
Hydraulic network calibration model is to minimize the sum of squares differences between calibrated and initial pipe roughness estimates, under a set constraints determined from sensitivity matrix. The upgrading problem water distribution system was put forward after preferable obtained. Radial Basis Function neural (RBF) based on genetic algorithm (GA) proposed solve model. Genetic applied optimize parameters network, overcome over-fitting problem. Case study concludes that using good results were