A5110571422- Ovarian function and disorders
- Menopause: Health Impacts and Treatments
- Noise Effects and Management
- Menstrual Health and Disorders
- Effects and risks of endocrine disrupting chemicals
- Thermoregulation and physiological responses
- Pregnancy and preeclampsia studies
- Animal Genetics and Reproduction
- Trace Elements in Health
- Protein Tyrosine Phosphatases
- Body Composition Measurement Techniques
- Galectins and Cancer Biology
- Air Quality and Health Impacts
- Effects of Vibration on Health
- Cancer Risks and Factors
- Climate Change and Health Impacts
- Nutrition and Health in Aging
- Congenital heart defects research
- Hearing Loss and Rehabilitation
- Pluripotent Stem Cells Research
- Gestational Trophoblastic Disease Studies
- Phytoestrogen effects and research
- Appendicitis Diagnosis and Management
- Birth, Development, and Health
- Pregnancy and Medication Impact
Women's Hospital, School of Medicine, Zhejiang University
2021-2025
First Affiliated Hospital Zhejiang University
2022-2025
Zhejiang University
2018-2023
National Natural Science Foundation of China
2022
Zhejiang Medicine (China)
2022
Weatherford College
2022
To determine the influence of environmental endocrine disruptor bisphenol A (BPA) on germ cell cyst breakdown and explore possible mechanisms regulating this activity.BPA (2 μg/kg/d or 20 μg/kg/d) tocopherol-stripped corn oil (vehicle control) was administered to pregnant mice by gavage at gestational day 11, offspring (prenatally treated mice) were sacrificed ovariectomized postnatal (PND) 4 PND22. Ovarian morphology documented in first filial (F1) generation female offspring, follicles...
Vascular endothelial (VE)-cadherin junctional localization is known to play a central role in vascular development, barrier integrity, and homeostasis. The sarcoma homology domain containing protein tyrosine phosphatase (SHP)2 has been shown be involved regulating function; however, the mechanisms remain largely unknown. In this work SHP2 knockdown an HUVEC monolayer increased VE-cadherin internalization permeability. Loss of specifically augmented GTPase activity ADP-ribosylation factor...
To comprehensively investigate and evaluate the prevalence, severity, associated factors of menopausal symptoms in women with premature ovarian insufficiency (POI). In this study, specific symptomatology experienced by POI natural menopause was also compared.In cross-sectional 293 Chinese from an outpatient clinic were recruited between June 2014 January 2019. The prevalence severity assessed modified Kupperman Menopausal Index. Participants completed a structured questionnaire, including...
Abstract Objective Menopausal transition has been known to be associated with the loss of muscle mass. However, health in women premature menopause, that is, ovarian insufficiency (POI), remains unclear. We aimed investigate and compare mass parameters prevalence low between patients spontaneous POI healthy controls. Methods In this cross-sectional study, 59 57 premenopausal controls normal function were enrolled at Women's Hospital, Zhejiang University School Medicine (Hangzhou, China) from...
Abstract Background Previous studies have indicated that women with a history of menstrual disorders an increased risk metabolic and cardiovascular diseases. This has been attributed to the high proportion polycystic ovary syndrome (PCOS) among this group. The favorable effects hormone replacement therapy (HRT) on serum lipid profiles glucose homeostasis in postmenopausal is widely accepted. Whether HRT can also show positive menopausal prior (a putative PCOS phenotype) not reported yet. aim...
Homeostasis disturbance of trace elements has been linked to adverse reproductive consequences, including premature ovarian insufficiency (POI) in women, but limited evidence reported so far. This case-control study evaluated the associations between 5 common urinary [copper (Cu), manganese (Mn), Iron (Fe), Selenium (Se), and zinc (Zn)] odds for POI. Urinary concentrations these metals serum levels POI-related hormones 169 cases 209 healthy controls were measured. The Cu Se women with POI...
Background: Retroperitoneal ectopic pregnancy (REP) is a rare form of pregnancy, in which fertilised eggs are implanted the retroperitoneal cavity. Due to its atypical location and non-specific symptoms, REP often misdiagnosed, leading delayed treatment. This condition poses serious risks owing proximity blood vessels. Limited research lack specific guidelines make management challenging. Case Report Literature Review: A 47-year-old woman with was initially misdiagnosed as having acute...
Adequate evidence showed hormone therapy (HT) reduces the risk of new-onset diabetes in midlife women by decreasing fasting glucose and insulin. However, improvement these diabetic biomarkers varied with each individual clinical observations. The objective our study was to investigate potential baseline factors associated change insulin during HT.A retrospective cohort performed among 263 participants aged 40 60 years menopausal symptoms who have received 6-month individualized HT....