Abstract Ecosystem restoration has traditionally focused on re-establishing vegetation and other foundation species at basal trophic levels, with mixed outcomes. Here, we show that threatened shorebirds could be important to restoring coastal wetland multifunctionality. We carried out surveys manipulative field experiments in a region along the Yellow Sea affected by invasive cordgrass Spartina alterniflora . found planting native plants alone failed restore multifunctionality experiment....

Competing endogenous RNAs (ceRNAs) are a newly discovered class of molecular regulators involved in many diseases, especially tumors.Therefore, exploration the potential ceRNA regulatory network regarding occurrence and development pancreatic cancer will provide new theoretical basis for its diagnosis treatment.Based on above background, we applied bioinformatics approach to mine public database The Cancer Genome Atlas (TCGA) performed series subsequent biology assays confirm hypothesis that...

Hepatocellular carcinoma (HCC), the most common liver cancer, occurs mainly in men, but underlying mechanism remains to be further explored. Here, we report that ubiquitinated glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is responsible for HCC tumorigenesis males. Mechanistically, FBXW10 promotes GAPDH polyubiquitination and activation; VRK2-dependent phosphorylation of Ser151 residue critical ubiquitination activation. Activated interacts with TRAF2, leading upregulation canonical...

The security of the Earth system has been extensively discussed through concept planetary boundaries, which hypothesizes Anthropocene as crisis for pushing environmental variables beyond safe limits. Cities, burgeoning population centers, warrant heightened attention to issues surrounding boundaries and ecological security. While groundwork laid change detection, acoustic or soundscape perspective is rarely considered. This paper presents abundant empirical evidence supporting feasibility...

Abnormal expression of E3 ubiquitin ligase plays an important role in the development and progression hepatocellular carcinoma (HCC), although mechanism has remained elusive. This study aimed to investigate biological function potential FBXO43 HCC.FBXO43 tissues cells were detected by quantitative real-time PCR (qRT-PCR), Western blot, immunohistochemistry (IHC). The Kaplan-Meier method Cox regression analysis used explore correlation between level clinical survival. MTT assay, EdU...

Suburban roads are an important part of China’s road network and essential infrastructure for rural development. Poorly designed curves scarcity traffic signs have caused excessively high accident rate in plain topographical areas. In this study, approach to evaluate improve safety is introduced. Based on fuzzy cask theory weighted analysis, a evaluation model built. It provides quantitative instant method analyzing the absence information or rigorous space data, by identifying dangerous...

Worldwide, cities are increasingly taking the burden of accommodating an extra population. It is undergoing most extensive anthropogenic transformation landscape, predominant modification biogeochemical processes, and intensive alteration biological communities. These severe ecological stresses in urgently call for research on coupled natural–human urban ecosystem. Soundscape, containing anthropogenic, biological, geological elements, can provide rich information natural artificial...

Biological requirements for tumor cell proliferation include the sustained increase of structural, energetic, signal transduction and biosynthetic precursors. Because lipids participate in membrane construction, energy storage, signaling. We hypothesized that differences between malignant carcinoma normal controls could be reflected bio-fluids. A total 100 pre-operative plasma samples were collected from 50 oral squamous (OSCC), patients characterize by lipid profiling using ultra...

The WRKY transcription factor (TF) family is one the largest plant-specific families. It has been proven to play significant roles in multiple plant biological processes, especially stress response. Although many TFs have identified various species, WRKYs white birch (Betula platyphylla Suk.) remain be studied. Here, we a total of 68 BpWRKYs, which could classified into four main groups. basic physiochemical properties these were analyzed using bioinformatics tools, including molecular...

Despite growing attention from researchers and governments, challenges persist in comprehensively assessing urban sound quality by integrating both quietness naturalness aspects. This study aimed to develop an innovative soundscape index that concurrently evaluates soundscapes. Our objectives included conducting mapping, analyzing influential mechanisms, identifying priority zones for environment management. We collected pressure level (SPL) raw audio data, which we computed a normalized...

The depressant β toxin anti-neuroexcitation peptide (ANEP) from the Chinese scorpion Buthus martensii Karsch has analgesic activity by interacting with receptor site 4 of voltage-gated sodium channels (VGSCs). Here, molecular dynamics simulations, we examined binding modes between ANEP and mice channel 1.7 (mNav1.7), a subtype VGSCs related to peripheral pain. Homology modeling, mechanics, in biomembrane environment were adopted. results suggested that bound resting mainly amino acid...

Far3p (factor arrest), a protein that interacts with Far7-11p, is required for the pheromone-mediated cell cycle arrest in G1 phase. We used combination of computational and experimental strategies to identify self-association, map domains interact itself other Far proteins, reveal importance two coiled-coil motifs integrity function complex. show self-associates through its central region C-terminal domain, amino acid 61-100 Far7p, N-terminal domain Far9p Far10p. Mutation coiled coil...

Based on a multilevel nonlinear mixed-effect model approach, stand basal area was developed for Cunninghamia lanceolata (Lamb.) Hook. plantations belonging to the National Forest Inventory in China. The database consists of 583 plots embracing 18 different blocks within three seed source sites this study. Of plots, 80% were randomly selected fitting and 20% carried out validation. modified Chapman–Richards Schumacher models evaluated find basic model. explanatory variables included dominant...

As a result of abnormal wound healing in susceptible individuals, keloids are characterized by hyperproliferation fibroblasts and excessive deposition the extracellular matrix (ECM). Current surgical therapeutic modalities provide limited satisfactory results. Circular ribonucleic acids (circRNAs) play crucial role pathogenesis various fibrotic diseases, but potential biological function expression profile circRNAs keloid formation remain unknown. In this study, we explored circFoxp1 on...