A5059365258- Menopause: Health Impacts and Treatments
- Endometriosis Research and Treatment
- Estrogen and related hormone effects
- Ovarian function and disorders
- Phytoestrogen effects and research
- Immunodeficiency and Autoimmune Disorders
- Antioxidant Activity and Oxidative Stress
- Menstrual Health and Disorders
- Uterine Myomas and Treatments
- Glycosylation and Glycoproteins Research
- Thyroid Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Effects and risks of endocrine disrupting chemicals
- Coenzyme Q10 studies and effects
- Stress Responses and Cortisol
- Gynecological conditions and treatments
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Pregnancy and preeclampsia studies
- Noise Effects and Management
- Surface Modification and Superhydrophobicity
- Cancer Risks and Factors
- Kruppel-like factors research
- Hormonal Regulation and Hypertension
- Wnt/β-catenin signaling in development and cancer
Women's Hospital, School of Medicine, Zhejiang University
2016-2025
Weatherford College
2022-2023
Credo Reference (United States)
2023
Zhejiang University
2023
National Natural Science Foundation of China
2022
Zhejiang Medicine (China)
2022
Nanchang Hangkong University
2022
Pyrethroids are a class of widely used insecticides. Female animal studies suggested that pyrethroid exposure impaired ovarian function, which resulted in similar symptoms primary insufficiency (POI). However, it is still unknown whether this association applies to women. In case-control study, total 172 POI patients and 247 control women were recruited Zhejiang, China. The urinary concentrations metabolites pyrethroids, 3-phenoxybenzoic acid (3-PBA) 4-fluoro-3-phenoxybenzoic (4-F-3-PBA), as...
The aim of the study was to specify prevalence and severity menopausal symptoms, investigate associated factors in Chinese middle-aged women.A cross-sectional, community-based carried out involving 1,054 participants aged 40 60 years Gongshu District, Hangzhou, Zhejiang, PR China. presence symptoms were evaluated by having complete a modified Kupperman Menopausal Index questionnaire. Serum levels follicle-stimulating hormone estradiol measured. Physical sociodemographic characteristics...
The etiology of depression involves many biological and environmental factors, among which the inflammatory process is an important contributor. However, role pro-inflammatory cytokines in postmenopausal unclear. Therefore, we aimed to explore association between serum concentrations four (IL-1β, IL-6, IL-18, TNF-α) depressive symptoms women who had been receiving menopause hormone therapy (MHT) for at least 6 months not received MHT. This study included a total 136 Chinese aged 40 65 years...
Lipid alteration in postmenopausal women is commonly due to hormonal changes. This study aimed explore the association between years since menopause and lipid profiles women. In this cross-sectional study, a total of 1033 were recruited from Women's Hospital Zhejiang University China 2015 2022. Each participant was interviewed using questionnaires regarding sociodemographic reproductive data. Anthropometric measurements, profiles, hormone levels assessed. Participants divided into 3 groups...
This study aimed to identify the risk factors and sonographic variables that could be integrated into a predictive model for endometrial cancer (EC) atypical hyperplasia (AEH) in women with abnormal uterine bleeding (AUB).This retrospective included 1837 patients who presented AUB underwent sampling. Multivariable logistic regression was developed based on clinical covariates [endometrial thickness (ET), resistance index (RI) of vasculature] assessed their association EC/AEH development...
Menopause is a significant life transition for women, impacting their physical and psychological health. The age at natural menopause (ANM) its associated factors have differed by race region. This study aimed to investigate ANM of early late among Chinese women in Zhejiang province.
Abstract Objective More than 2 billion women are experiencing menopause transition in China and some of them suffered from depression; while the risk factors depression during were still unclearin China. We aimed to investigate mid-life Southeast Method This study included 1748 Chinese aged 40–65 years-old who visited gynecology outpatient department Women’s hospital School Medicine, Zhejiang University 2010–2018. Demographic information was collected, modified Kupperman Menopausal Index...
The use of hormone replacement therapy (HRT) started later in China than European countries. purpose the present study was to investigate HRT patterns and reasons for initiation discontinuation among women South China.A telephone survey about menopausal status, HRT, duration treatment conducted 2014.A total 825 surveys were carried out, 217 previous users 390 current recruited this study. Among these 607 subjects, 50.7% sought out hot flushes, 41.6% fatigue 41.5% sleeplessness. Approximately...
To determine the influence of environmental endocrine disruptor bisphenol A (BPA) on germ cell cyst breakdown and explore possible mechanisms regulating this activity.BPA (2 μg/kg/d or 20 μg/kg/d) tocopherol-stripped corn oil (vehicle control) was administered to pregnant mice by gavage at gestational day 11, offspring (prenatally treated mice) were sacrificed ovariectomized postnatal (PND) 4 PND22. Ovarian morphology documented in first filial (F1) generation female offspring, follicles...
To comprehensively investigate and evaluate the prevalence, severity, associated factors of menopausal symptoms in women with premature ovarian insufficiency (POI). In this study, specific symptomatology experienced by POI natural menopause was also compared.In cross-sectional 293 Chinese from an outpatient clinic were recruited between June 2014 January 2019. The prevalence severity assessed modified Kupperman Menopausal Index. Participants completed a structured questionnaire, including...
Objective: The aim of this study was to compare health-related quality life (HRQOL) by menopausal stage and investigate its associated factors in middle-aged Chinese women.Method: This a cross-sectional, community-based involving 868 participants aged 40–60 years Gongshu District, Hangzhou, Zhejiang, PR China. HRQOL assessed the Short-Form Health Survey (SF-36). symptoms sociodemographic characteristics were surveyed.Results: median (25–75th percentile) age all 51.24 (46.37–55.55) years....
Abstract Objective Menopausal transition has been known to be associated with the loss of muscle mass. However, health in women premature menopause, that is, ovarian insufficiency (POI), remains unclear. We aimed investigate and compare mass parameters prevalence low between patients spontaneous POI healthy controls. Methods In this cross-sectional study, 59 57 premenopausal controls normal function were enrolled at Women's Hospital, Zhejiang University School Medicine (Hangzhou, China) from...
Abstract Objective To compare the vaginal microbiota of premenopausal and postmenopausal women undergoing menopausal hormone therapy (MHT) examine association between genitourinary syndrome menopause (GSM). Methods This cross-sectional study classified 94 aged 40 to 60 years into three groups: (Pre, n = 32), (Post, 30), who received MHT orally (Post + MHT, 32). Neither Pre nor Post group within past 6 months. Postmenopausal were not included. Vaginal swabs obtained, microbial composition was...
Objectives: To explore the serum levels of bone resorption marker C-terminal telopeptide type I collagen (CTX) and formation N-amino terminal propeptide (PINP) in Chinese women across menopausal transition correlation between follicle stimulating hormone (FSH), luteinizing (LH) estradiol with turnover markers.Methods: A cross-sectional study was conducted on 464 healthy women, separated into pre-, peri- postmenopausal groups based their menstruation changes. The CTX, PINP, FSH, LH, were...
Abstract Background Previous studies have indicated that women with a history of menstrual disorders an increased risk metabolic and cardiovascular diseases. This has been attributed to the high proportion polycystic ovary syndrome (PCOS) among this group. The favorable effects hormone replacement therapy (HRT) on serum lipid profiles glucose homeostasis in postmenopausal is widely accepted. Whether HRT can also show positive menopausal prior (a putative PCOS phenotype) not reported yet. aim...
A few epidemiological investigations and animal studies have demonstrated that bisphenol (BPA) may affect female reproductive health. However, no epidemiologic study has investigated the relationship between BPA exposure risk of premature ovarian insufficiency (POI).In this case-control study, urinary concentrations serum levels hormone were measured. Associations POI POI-related estimated.Among quartiles, obvious association was found (p = 0.603). Although adjusted odds ratio (OR) slightly...
Abstract Aim The aim of this study is to investigate the role vitamin E in etiology premature ovarian insufficiency (POI). Methods This included a total 96 matched cases and controls, including case group composed 40 women with POI, control 56 normal menstrual cycles. Serum levels (also known as α‐tocopherol), cholesterol, follicle stimulating hormone (FSH), luteinizing (LH) anti‐Müllerian (AMH) were determined. relationship α‐tocopherol FSH, LH AMH evaluated using regression models. Results...
To evaluate the endocrine hormone and metabolic indices in postmenopausal women with euthyroid mild subclinical hypothyroidism after menopause therapy (MHT).A retrospective study of 587 receiving MHT was conducted. Median (25-75th percentile) age 52 (49-54) years. According to thyroid stimulating (TSH) levels at initial diagnosis, patients were divided into three groups: I (euthyroid low normal TSH range, n = 460), II upper 106) III (mild hypothyroidism, 21). After a continuous oral regimen...
Candida albicans (C. albicans) is an opportunistic fungus that quickly adapts to various microniches. It causes candidiasis, a common fungal infection for which the pathogenic mechanism has not been elucidated yet. To explore of candidiasis we used several methods, including microscopic observation morphological changes HeLa cells and fungus, analysis differentially expressed genes using gene chips, series biological bioinformatic analyses are possibly involved in pathogenesis C. albicans....