A5100321476- Pancreatic and Hepatic Oncology Research
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- Autophagy in Disease and Therapy
- MicroRNA in disease regulation
- Pancreatic function and diabetes
- Cancer-related Molecular Pathways
- HER2/EGFR in Cancer Research
- Liver Disease Diagnosis and Treatment
- Renal Diseases and Glomerulopathies
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Research and Treatments
- RNA regulation and disease
- Genomics, phytochemicals, and oxidative stress
- Monoclonal and Polyclonal Antibodies Research
- Cancer Treatment and Pharmacology
- Folate and B Vitamins Research
- Phagocytosis and Immune Regulation
- Cell death mechanisms and regulation
- Radiomics and Machine Learning in Medical Imaging
- Galectins and Cancer Biology
- melanin and skin pigmentation
- Kawasaki Disease and Coronary Complications
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Genetics and Neurodevelopmental Disorders
Sun Yat-sen University
2011-2024
Sun Yat-sen University Cancer Center
2011-2024
State Key Laboratory of Oncology in South China
2020-2024
Sir Run Run Shaw Hospital
2024
Zhejiang University
2024
Ocean University of China
2024
Medical College of Wisconsin
2020-2024
Peking University
2016-2023
Ningxia Medical University General Hospital
2022-2023
Ningxia Medical University
2022-2023
The loss of microRNA-122 (miR-122) expression correlates to many characteristic properties hepatocellular carcinoma (HCC) cells, including clonogenic survival, anchorage-independent growth, migration, invasion, epithelial-mesenchymal transition, and tumorigenesis. However, all these findings do not sufficiently explain the oncogenic potential miR-122. In current study, we used two-dimensional differential in-gel electrophoresis measure changes in thousands proteins response inhibition...
Abstract KRAS is mutated in most pancreatic ductal adenocarcinomas (PDAC) and yet remains undruggable. Here, we report that p38γ MAPK, which promotes PDAC tumorigenesis by linking signaling aerobic glycolysis (also called the Warburg effect), a novel therapeutic target. interacted with glycolytic activator PFKFB3 was dependent on KRAS. transformation overexpression of increased expression glucose transporter GLUT2, conversely, silencing mutant KRAS, decreased GLUT2 expression. phosphorylated...
Vitiligo is an acquired autoimmune skin disorder, clinically characterized by distinct white macules and patches resulting from progressive melanocyte destruction. JAK-STAT pathway plays important role in the loss of epidermal melanocytes. Baricitinib can block downstream chemokines as a new JAK1/2 inhibitor. In this report, we describe successful treatment 2 patients with oral baricitinib combined NB-UVB phototherapy, which provides good alternative supplementary to treat refractory vitiligo.
Apoptosis signal–regulating kinase 1 (ASK1) is activated by various stresses. The link between ASK1 activation and endoplasmic reticulum (ER) stress, two causal events in diabetic embryopathy, has not been determined. We sought to investigate whether involved the unfolded protein response (UPR) that leads ER stress. Deleting Ask1 abrogated diabetes-induced UPR suppressing phosphorylation of inositol-requiring enzyme 1α (IRE1α), double-stranded RNA-activated (PKR)-like (PERK) blocked...
AIMTo clarify the mechanisms involved in critical endoplasmic reticulum (ER) stress initiating unfolded protein response pathway modified by melatonin. METHODSHepatoma cells, HepG2, were cultured vitro .Flow cytometry and TUNEL assay used to measure HepG2 cell apoptosis.Western blotting quantitative reverse transcription-polymerase chain reaction methods determine messenger RNA levels of ER apoptosis related genes' expression, respectively.Tissue microarray construction from patients was...
The naturally occurring compound α-pinene induces cell cycle arrest and antitumor activity. We examined effects of on regulation in hepatocellular carcinoma cells (HepG2) to establish a foundation for its development as novel treatment (HCC). HepG2 treated with exhibited dose-dependent growth inhibition result G2/M-phase arrest. Cell was associated down-regulated cyclin-dependent kinase 1 (CDK1) miR-221 levels up-regulated CDKN1B/p27, γ-H2AX, phosphorylated ATM, Chk2 p53. Our observations...
Objective To establish a radiomics model based on intratumoral and peritumoral features extracted from pre-treatment CT to predict the major pathological response (MPR) in patients with non-small cell lung cancer (NSCLC) receiving neoadjuvant immunochemotherapy. Methods A total of 148 NSCLC who underwent immunochemotherapy two centers (SRRSH ZCH) were retrospectively included. The SRRSH dataset (n=105) was used as training internal validation cohort. Radiomics (T) regions (P1 = 0-5mm, P2...
To explore the relationship between preoperative serum CA19-9 and CEA levels prognosis of pancreatic cancer (PC).The clinicopathological data 128 patients with adenocarcinoma who were treated in our center January 2012 December 2013 retrospectively analyzed. The relationships survival analyzed using Kaplan-Meier method, log-rank test, Cox regression analysis. cut-off values for 39 U/mL 4.7 ng/mL, respectively.Among these patients, mean age was 62 years, median 12.2 days. positive rate 78.1%...
Both the voltage-dependent anion channel and glucose-regulated protein 78 have been identified as plasminogen kringle 5 receptors on endothelial cells. In this study, we demonstrate that binds to a region localized in N-terminal domain of 78, whereas microplasminogen does so through C-terminal 78. fragments induce Ca(2+) signaling cascades; however, acts via Because trafficking cell surface is associated with heat shock proteins, investigated possible association between 1-LN human prostate...
Glucose-regulated protein 78 (GRP78) is one of the most important responders to disease-related stress. We assessed association promoter polymorphisms GRP78 with risk hepatocellular carcinoma (HCC) and expression in a Chinese population. examined 1007 patients undergoing diagnostic HCC 810 unrelated healthy controls. Mechanisms by which polymorphism modulates levels were analyzed. The haplotype diplotype carrying rs391957 (−415bp) allele G genotype GG was strongly associated risk. Luciferase...
ATP-binding cassette subfamily G member 2 (ABCG2), a of the ABC transporter superfamily proteins, mediates multidrug resistance (MDR) by transporting substrate anticancer drugs out cancer cells and decreasing their intracellular accumulation. MDR is major hurdle to successful chemotherapy. A logical approach overcome inhibit transporter. However, no safe effective inhibitor has been approved in clinic. The MTT assay was used evaluate cell cytotoxicity reversal effect. Drug efflux drug...
Endoplasmic reticulum (ER) stress and caspase 8-dependent apoptosis are two interlinked causal events in maternal diabetes-induced neural tube defects (NTDs). The inositol-requiring enzyme 1α (IRE1α) signalosome mediates the proapoptotic effect of ER stress. Diabetes increases tumor necrosis factor receptor type 1R-associated death domain (TRADD) expression. Here, we revealed new unfolded protein response (UPR) regulators, TRADD Fas-associated with (FADD). interacted both IRE1α-TRAF2-ASK1...
The neutrophil–lymphocyte ratio (NLR) is an emerging cardiovascular risk factor. Patients with mixed plaques (MPs) or noncalcified (NCPs) have a higher of poor outcomes. However, there are few published data on the relationship between NLR and presence NCP MP (NCP/MP). We retrospectively collected clinical laboratory 598 patients chest pain. According to whether they had coronary atherosclerotic characteristics most stenotic plaque, we divided them into no calcified plaques, NCP, MP. Those...
Anterior gradient 2 (AGR2), a protein disulfide isomerase (PDI), is well-established oncogene.Here, we found that Agr2 -/-mice had decreased fat mass and hepatic serum lipid levels compared with their wild-type littermates after fasting, exhibited reduced high-fat diet (HFD)-induced accumulation.Transgenic mice overexpressing AGR2 (Agr2/Tg) readily gained weight on HFD but not normal diet.Proteomic analysis of samples from revealed depletion impaired long-chain fatty acid uptake activation...
Flare-ups of chronic hepatitis B can sometimes be severe and even progress to acute-on-chronic liver failure (ACLF), with high short-term mortality. A timely estimation the risk death should initiated early. The aim present study was determine whether novel biomarkers add prognostic information beyond current clinical scoring systems.Patients B-associated ACLF were prospectively enrolled from five hospitals in China between August 2017 March 2018. Their plasma screened for soluble CD163...
SUMMARY Pancreatic Ductal Adenocarcinoma (PDAC) is a lethal disease with limited treatment options and poor survival. We studied 73 samples from 21 patients (7 treatment-naïve 14 treated neoadjuvant regimens), analyzing distinct spatial units performing bulk proteogenomics, single cell sequencing, cellular imaging. Spatial drivers, including mutant KRAS , SMAD4 GNAQ, were associated differential phosphosignaling metabolic responses compared to wild type. Single subtyping discovered 12 of...
Objective. To improve the diagnostic capacity of serum biomarkers for colorectal cancer (CRC), we introduced three novel indicators, namely, C-X-C motif chemokine ligand 5 (CXCL5), stanniocalcin 2 (STC2), and chitinase 3 like 1 (CHI3L1) assessed their performances in detection CRC. Methods. A total 887 samples (153 health, 342 polyps, 392 CRCs) were collected. Concentrations CXCL5, STC2, CHI3L1 measured by ELISA. CEA CA199 determined electrochemiluminescence. Binary logistic regression was...
To select the most efficient chemical to induce apoptosis in leukemia cells, a multidrug screen was applied on bone marrow mononuclear cells from chronic myeloid (CML) patients. Oprozomib (Cpd 21) chosen for subsequent experiments. The isobaric tags relative and absolute quantitation (iTRAQ) then performed identify responsible pathway results showed that endoplasmic reticulum (ER) chaperones were upregulated. Apoptosis attributed joint effect of calcium leakage andPERK IRE1α phosphorylation....