A5101916520- Intracerebral and Subarachnoid Hemorrhage Research
- Pain Mechanisms and Treatments
- Meningioma and schwannoma management
- Traumatic Brain Injury and Neurovascular Disturbances
- Metabolism and Genetic Disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Immune cells in cancer
- Nerve injury and regeneration
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Neurosurgical Procedures and Complications
- Hereditary Neurological Disorders
- Gynecological conditions and treatments
- Colorectal Cancer Treatments and Studies
- Head and Neck Surgical Oncology
- Mitochondrial Function and Pathology
- HIV, Drug Use, Sexual Risk
- Pituitary Gland Disorders and Treatments
- Genetic factors in colorectal cancer
- Ophthalmology and Eye Disorders
- Pharmacogenetics and Drug Metabolism
- Heart Failure Treatment and Management
- Intracranial Aneurysms: Treatment and Complications
- Botulinum Toxin and Related Neurological Disorders
- Heme Oxygenase-1 and Carbon Monoxide
Hubei Provincial Hospital of Traditional Chinese Medicine
2021-2023
Soochow University
2020-2022
First Affiliated Hospital of Soochow University
2020-2022
Weatherford College
2021
Qinghai Provincial Peoples Hospital
2021
West China Medical Center of Sichuan University
2021
Lanzhou University
2021
Fuzhou University
2017
Sichuan University
2009
West China Hospital of Sichuan University
2009
Upregulation of neuronal oxidative stress is involved in the progression secondary brain injury (SBI) following intracerebral hemorrhage (ICH). In this study, we investigated potential effects and underlying mechanisms luteolin on ICH-induced SBI. Autologous blood oxyhemoglobin (OxyHb) were used to establish vivo vitro models ICH, respectively. Luteolin treatment effectively alleviated edema ameliorated neurobehavioral dysfunction memory loss vivo. Also, vivo, found that promoted activation...
The activation of microglia and inflammatory responses is essential for the process intracerebral hemorrhage (ICH)-induced secondary brain injury (SBI). In this study, we investigated effects luteolin on ICH-induced SBI potential mechanisms. Autologous blood was injected to establish ICH model in vivo, oxyhemoglobin (OxyHb) used mimic vitro. We found that administration significantly improved motor sensory impairments inhibited neuronal cell degeneration vivo. vitro decrease viability...
Surgical brain injury (SBI) triggers microglia to release numerous inflammatory factors, leading edema and neurological dysfunction. Reducing neuroinflammation protecting the blood-brain barrier (BBB) are key factors improve function prognosis after SBI. Na + -K -Cl – cotransporter 1 (NKCC1) nuclear factor κB (NF-κB) have been implicated in secretion of cytokines by injury. This study aimed establish role NKCC1 inducing inflammation SBI, as well determine whether controls interleukin-1β...
miRNA is an essential factor in neuropathic pain. However, the underlying mechanism of pain remains unclear.To explore potential role miR-223 a mice model chronic sciatic nerve injury.Mice were divided into sham group, CCI + Lenti-vector and Lenti-miR-223 group. Flow cytometry was used to detect neuronal apoptosis proportion M1/M2 macrophages each Western blot protein expression levels ASC, caspase-1, IL-1β, IL-18 Luciferase activity assay detects binding NLRP3. Macrophage chemotaxis...
Gastric cancer (GC) remains a major world-wide challenge, especially in Asian countries. Chemotherapy with 5-fluorouracil (5-FU) and cisplatin is used as the first-line treatment development of chemoresistance cause progression. UMP/CMP kinase responsible for phosphorylation ribonucleotide metabolite 5-fluoro-5′-monophosphate (FUMP) 5-FU metabolic process, recognized key step conversion to cytotoxic metabolites. Our bioinformatics analysis molecular experiments demonstrated that high...
Metapristone is the primary metabolite of abortifacient mifepristone (RU486), and being developed as a safe effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated sex-related pharmacokinetics metapristone in rats dogs, explored related mechanisms actions. Administration to dogs showed that plasma concentrations (AUC, C max ) were significantly higher female than males. The differences become more significant after ten consecutive days oral...
Biomarkers have played an important role in the treatment and management of patients with congenital heart disease (CHD). The 100 most frequently cited articles addressing possible biomarkers assessment outcomes CHD were reviewed.The Web Science Core Collection database was selected as for this selection publications. CiteSpace 5.7.R1 VOSviewer 1.6.9 used to analyze information.A total 877 referencing cardiac identified search period January 1980-June 2020. After screening, top finally...
<h3>Objective:</h3> Craniopharyngiomas with predominant pars in the posterior fossa are very rare and extremely overlooked. The clinical features, diagnosis management different from their sellar/suprasellar counterparts. purpose of this study was to explore differing characteristics craniopharyngiomas. <h3>Methods:</h3> Seven patients pathologically proven craniopharyngiomas located were retrospectively investigated. data radiographic findings presented analysed. <h3>Results:</h3> primary...
In Brief BACKGROUND: Using a rat L5 spinal nerve transection model we previously showed that pentoxifylline prevents hyperalgesia through antiinflammation in the prefrontal brain. this study, examined efficacy when applied after injury. METHODS: We effect of on existing mechanical allodynia, observing glial activation and proinflammatory cytokine expression lumbar cord, given 7 days transection. RESULTS: There was no from hypersensitivity, activation, CONCLUSION: Pentoxifylline administered...
Aim: The study aimed to probe into the functions and mechanisms of miR-3188 in hepatocellular carcinoma (HCC). Materials & methods: Quantitative real-time PCR western blot were implemented detect expressions CXCL14 HCC tissues cell lines. CCK-8, 5-ethynyl-2′-deoxyuridine flow cytometry assays performed assess viability, proliferation apoptosis. A dual-luciferase reporter assay was conducted investigate relationship between CXCL14. Results: is up-regulated tissues. MiR-3188 overexpression...
Objective: To analyze and reveal the distribution, research hotspots study trend of worldwide published articles correlated with HIV/AIDS post-exposure prophylaxis (PEP), provide information for related studies in China. Methods: CiteSpace software 5.1 was used to visualize all papers web science database during 2000-2017. Results: The average growth rate international PEP-related 10.78%,and number 2016 highest (n=34), relevant have shifted from prevention occupational HIV exposure...
Lymphoplasmacyte-rich meningioma (LPRM) is a rare characterized by significant infiltration of plasma cells and lymphocytes, changes in the ratio meningeal epithelial components. According to World Health Organization, tumors central nervous system are classified as grade I tumors.A 44-year-old man presented our department with complaints limb weakness accompanied hand numbness. Half month before admission, patient's worsened he could not walk raise his hands, sensory disturbance...
Abstract Mitochondrial dysfunction caused by mitochondrial DNA (mtDNA) damage and mutation is widely accepted as one of the pathological processes neurodegenerative diseases. As an mtDNA binding protein, transcription factor A (TFAM) maintains integrity through transcription, replication, nucleoid formation, perception, repair. In recent works, overexpression TFAM increased copy count, promoted function, improved neurological The role in diseases has been well explained. However, after...