Objective To examine trends in varicella and herpes zoster (HZ) hospitalization following the availability subsequent National Immunization Programme funding of one-dose vaccination Australia.Methods Varicella coverage for children born between 2001 2009 was obtained from Australian Childhood Register.Principal or any coded HZ hospitalizations were retrieved national hospital morbidity database 1998 to 2010.Trends rates different age groups indigenous status assessed.Incidence rate ratios...

Intracranial solitary fibrous tumor (SFT) and hemangiopericytoma (HPC) are rare mesenchymal tumors with significant vascularization, often misdiagnosed as meningiomas. Surgical resection is the primary treatment, postoperative radiotherapy increasingly recognized for its role in improving recurrence-free survival. However, standard regimens remain undefined. We retrospectively analyzed clinical data from 12 patients diagnosed SFT/HPC who underwent surgical intensity-modulated radiotherapy....

Long noncoding RNAs (lncRNAs) have been reported to play diverse roles in biologic and pathologic processes, including myogenesis. We found that lncRNA AK017368 is highly expressed skeletal muscle cells. Functional analyses showed overexpression of promoted proliferation restrained differentiation myoblasts; whereas inhibition had completely opposite effects vitro. In mice, knockdown hypertrophy vivo. RNA molecules acted mechanistically as competing endogenous target micro-RNA (miR)-30c,...

Background Gastrointestinal stromal tumors (GISTs) and gastrointestinal leiomyomas (GILs) are the most common subepithelial lesions (SELs). All GISTs have malignant potential; however, GILs considered benign. Current imaging cannot effectively distinguish from GILs. We aimed to develop an artificial intelligence (AI) system differentiate these using endoscopic ultrasonography (EUS). Methods The AI was based on EUS images of patients with histologically confirmed or Participants four centers...

Abstract Meat color is considered to be the most important indicator of meat quality, however, molecular mechanisms underlying traits related remain mostly unknown. In this study, elucidate basis color, we constructed six cDNA libraries from biceps femoris (Bf) and soleus (Sol), which exhibit obvious differences in analyzed whole-transcriptome between Bf (white muscle) Sol (red using high-throughput sequencing technology. Using DEseq2 method, identified 138 differentially expressed genes...

The objective of this study was to establish the optimum protocol for isolation and culture porcine muscle satellite cells. Mononuclear cells are a kind adult stem cell, which is located between basal lamina sarcolemma fibers primary source myogenic precursor in postnatal muscle. Muscle useful model investigate mechanisms growth development. Although protocols some species (e.g. mouse) have been established successfully, system very limited. In study, we optimized procedure elaborated...

ABSTRACT Background: Pulmonary arterial hypertension (PAH) is a life-threatening cardiopulmonary disorder. LncRNA-Ang362 (lnc-Ang362) regulates miR-221 and miR-222 in vascular smooth muscle cell proliferation, which can lead to PAH. The present study was designed investigate the function underlying mechanisms of lnc-Ang362 Methods: expression lnc-Ang362, miR-221, 15 PAH patients 10 healthy controls measured by qRT-PCR. Lnc-Ang362 overexpression vector siRNA were transfected into human...

Triple-negative breast cancer (TNBC) is a highly heterogeneous tumor that lacks effective treatment and has poor prognosis. Exosomes carry abundant genomic information have significant role in tumorigenesis, metastasis, drug resistance. However, further exploration needed to investigate the relationship between exosome-related genes heterogeneity immune microenvironment of TNBC. Based on gene sets, multiple machine learning algorithms, such as Cox boost, were used screen risk score model...

Herbivore-associated molecular patterns (HAMPs) in saliva enable plants to detect herbivores and activate pattern-triggered immunity (PTI). Piercing-sucking secrete gel saliva, forming salivary sheaths that assist feeding, however, the role of proteins within these modulation plant defenses remains poorly understood. Here, a thermostable HAMP, myosin light chain 1-like (myosin) is identified, from sheath small brown planthopper (SBPH) Laodelphax striatellus. Myosin widely conserved arthropod...

Retinal neovascularization, a pathological form of angiogenesis, is leading cause blindness. This study investigated the effects Dendrobium sulfate polysaccharide JCS1S2, derived from chrysogenum, on oxygen-induced retinopathy (OIR) in rat models and Müller cells retina. To this end, we established an OIR model divided rats into three primary groups, namely, Group I (control), II (OIR), III (OIR + JCS1S2). was further subdivided subgroups treated with different concentrations JCS1S2 (10...

This study retrospectively investigated the morphological, immunohistochemical and molecular genetic features of papillary renal neoplasm with reverse polarity (PRNRP), a recently described tumor.

Objective: Active surveillance to determine influenza disease burden in children admitted hospital with influenza‐like illness (ILI). Methods: A prospective hospital‐based cohort study conducted June–October 2006 <5 years hospitalised at The Children's Hospital Westmead ILI (fever and respiratory symptoms). Influenza other viral infections were diagnosed either by antigen detection using immunofluorescence or nucleic acid amplification testing of nasopharyngeal aspirates. Data collected...

Background: Recent studies have found that senescence-associated genes play a significant role in cancer biological processes. We aimed to analyze the characteristics and of triple-negative breast (TNBC). Methods: systematically screened secretory phenotype (SASP) based on gene expression information TCGA database. According levels genes, TNBC was classified into two subtypes, namely, TNBCSASP1 TNBCSASP2, using an unsupervised cluster algorithm. then performed expression, enrichment pathway,...

Bone marrow-derived mesenchymal stem cell (BMSC) cytotherapy has emerged as a promising treatment strategy for refractory immune diseases; however, the influence of pathologic conditions donors on immunomodulatory properties BMSCs is still poorly understand. Here, we found that were derived from with osteoporosis ineffective patients experimental colitis and graft- vs.-host disease (GVHD). In vivo in vitro assays revealed capacity osteoporotic to induce T-cell apoptosis declined result...

This study aimed to explore the clinical detection and prognosis of coagulation function in patients with liver failure sepsis.The plasma fibrinogen (FIB), factor II, VII, V, IV, antithrombin III (ATIII), platelet (PLT), mean PLT volume (MPV), D-dimer, prothrombin activity (PTA), fibrin degradation product (FDP) levels thromboelastogram values were detected complicated sepsis compared those cirrhosis groups. The analyzed by univariate multivariate logistic regression, regression equation was...

// Long-Hai Feng 1, 2, 3, * , Han Wang Hui Dong 3 Yu-Yao Zhu and Wen-Ming Cong 1 Department of Pathology, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Yangpu, Shanghai, 200438, China 2 Key Laboratory Signaling Regulation Targeting Therapy Liver Cancer (Second University) Ministry Education, Shanghai Tumor Biology (Eastern Hospital ), Authors contributed equally to this work serve as co-first authors Correspondence to: Cong, email: wmcong@smmu.edu.cn...

Histone variant H3.3 is encoded by two distinct genes, H3F3A and H3F3B , that are closely associated with actively transcribed genes. replacement continuous essential for maintaining correct chromatin structure during mouse oogenesis. Upon fertilization, incorporated to parental chromatin, required blastocyst formation in mice. The exchange process facilitated the chaperone HIRA, particularly zygote development. We previously demonstrated bovine early embryonic development; here, we explored...

Yellowing leaves are ideal materials for studying the metabolic pathways of photosynthetic pigment chloroplast development, and mechanism systems. Here, we obtained a triploid material HCC (2n = 3x 26), which was derived from hybridization between artificial tetraploid