Background Gastrointestinal stromal tumors (GISTs) and gastrointestinal leiomyomas (GILs) are the most common subepithelial lesions (SELs). All GISTs have malignant potential; however, GILs considered benign. Current imaging cannot effectively distinguish from GILs. We aimed to develop an artificial intelligence (AI) system differentiate these using endoscopic ultrasonography (EUS). Methods The AI was based on EUS images of patients with histologically confirmed or Participants four centers...

The relationship between lead exposure and neurological disorders has been extensively studied, but the effects of on hepatotoxicity are unknown. Metabolically related fatty liver disease (MAFLD) is an update previous non-alcoholic (NAFLD). It redefines diagnostic conditions emphasizes metabolic factors while considering factors. Lead can affect endocrine system metabolism, so we believe that may contribute to MAFLD. 41,723 individuals who had undergone blood testing from 2005 2018 in...

Background Intrahepatic cholangiocarcinoma (ICCA) is a primary liver cancer characterized by rapid progression and poor prognosis. There are few effective tools for evaluating the prognosis of ICCA patients, use transplantation (LT) treatment still controversial. Methods We analyzed incidence data clinicopathological from Surveillance, Epidemiology, End Results database. Prognostic predictors were identified univariate multivariate Cox regression analyses then used to establish nomogram. The...

Liposarcoma, one of the most common soft tissue sarcomas, originates from primitive mesenchymal cells. However, spinal involvement liposarcoma, whether primary or metastatic, is rare. According to literature reports, myxoid/round cell liposarcomas are types affecting spine. Spinal liposarcomas, have only been sporadically reported. The author presents an unusual case recurrent myxoid liposarcoma originating erector spinae muscle, infiltrating upper thoracic spine in a 65-year-old female....

Capicua transcriptional repressor (CIC)-rearranged sarcoma, also known as CIC-rearranged sarcoma (CRS), is a recently recognized subtype characterized by specific molecular features. It associated with aggressive clinical course and poor prognosis. Here, we present rare case of CRS, including detailed clinical, pathological, analysis, to enhance understanding this disease provide reference for future diagnosis treatment. A 15-year-old female adolescent initially presented rapidly growing...

Abstract Progressive Familial Intrahepatic Cholestasis Type 3 (PFIC3) is a rare inherited liver disease caused by mutation in the ABCB4 gene, leading to dysfunction of multidrug resistance protein (MDR3). The earlier onset PFIC3 children is, more severe prognosis. diagnosis typically based on clinical symptoms, laboratory tests, and imaging assessments, with final confirmation requiring genetic testing. aim this study was investigate associations between mutations features, molecular...

Colon adenocarcinoma (COAD) is one of the most common malignant tumors. Tumor mutation burden (TMB) has become an independent biomarker for predicting response to immune checkpoint inhibitors (ICIs). miRNAs play important role in cancer-related regulation. However, relationship between miRNA expression and TMB COAD remains unclear. Therefore, transcriptome profiling data, clinical annotation profiles cases were downloaded from TCGA database. Subsequently, 323 randomly divided into training...

During weaning, babies and young animal often experience diarrhea from food intolerance and/or decreasing levels of maternal antibodies, tends to be particularly severe during the early-weaned period, which exhibits an underdeveloped immune system, a disturbed gut environment results in nutrient malabsorption dehydration. It was deduced that neuroendocrine might have close relation with diarrhea, especially 5-HT. To explore role serotonin (5-HT) weaning mice subjected stress-induced...

BACKGROUND This study used network pharmacology method and cell model to assess the effects of Radix Astragali (RA) on cholangiocarcinoma (CCA) predict core targets molecular mechanisms. MATERIAL AND METHODS We performed an in vitro effect RA CCA using CCK8 assay, Live-Cell Analysis System, trypan blue staining. The components were analyzed Traditional Chinese Medicine Systems Pharmacology database, genes associated with retrieved from GeneCards OMIM platforms. Protein-protein interactions...

Er Shen Zhenwu Decoction is a prescription for treating chronic heart failure of and kidney yang deficiency, while its active ingredients remain unclear difficult to identify. This paper aims apply rapid assay strategy ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry collect the data decomposed recipes (monarch, minister, assist). By comparing with retention time MSE fragmentation patterns, 67 34 components in vitro vivo were identified, respectively,...

Abstract Background Hepatocellular carcinoma (HCC) is one of the most common cancers in digestive system with rapid progression and poor prognosis. Recent studies have shown that RPL27A could be used as a biomarker for variety cancers, but its role HCC not clear. Method We analyzed expression pan-cancer analysis relationship between clinical features prognosis patients HCC. evaluated difference tissues paired normal adjacent using immunohistochemistry. Furthermore, we co-expression genes...

Abstract Background Seborrheic keratosis ( SK ) is one of the most common skin tumors seen by dermatologists. It should be differentiated with many diseases, especially tumors. Reflectance confocal microscopy RCM has been applied for evaluation . There are a few studies that describe The aim study was to find challenge diagnosing seborrheic reflectance microscopy. Methods A total 390 patients clinical suspicious diagnosis were enrolled in this study, and lesions from each patient imaged...

Background Biliary atresia (BA) is a serious biliary disease in infancy. Jaundice the most visual and prominent symptom, it mainly involves bile duct cells leading to loss of intrahepatic extrahepatic ducts. If left untreated, will eventually progress liver cirrhosis. The pathogenesis BA not clear, now generally accepted that an autoimmune disease. However, few studies have revealed infiltration immune from global perspective. We used tissue sequencing data predict relative content BA....

The chemical components of Xin'an famous prescription Ershen Zhenwu Decoction (ESZWD) are still unclear. results showed that ESZWD could significantly reduce left ventricular end diastolic diameter, decrease N-terminal pro-brain natriuretic peptide (NT-proBNP), angiotensinII, aldosterone, reactive oxygen species, and malondialdehyde, increase serum superoxide dismutase, while had no significant effect on inflammatory factors. Ultra-performance liquid chromatography/quadrupole-time-of-flight...

Background: We evaluated the Wellion Galileo GLU/KET blood and ketone (ß-Hydroxybutyrate, ß-OHB) meter to demonstrate that it meets ISO15107:2015 regulatory approval criteria.Research Design Methods: A total of 100 subjects (52 female, age: 30 84 years, diabetes: 10 type 1/90 2) with glucose levels distributed over entire measurement range as required by ISO15197 protocol were tested (double determinations 3 strip lots two devices). similar test was followed ß-OHB performance (reference...

Autophagy plays an important role in the occurrence and development of hepatocellular carcinoma (HCC). We aimed to develop autophagy-related genes signature predicting prognosis HCC depict a competing endogenous RNA (ceRNA) network.Differentially expressed (DE-ATGs), miRNAs lncRNAs clinical data patients were extracted from TCGA. The GO KEGG analysis performed investigate gene function. Univariate multivariate Cox regression used identify prognostic with DE-ATGs. And nomogram, adapted...

Zhenwu Decoction(ZWD) has a history of more than 1 800 years in traditional Chinese medicine(TCM), which is used to treat various diseases characterized by Yangqi deficiency and exuberant water dampness. It currently the classic prescription for treatment chronic heart failure(CHF). This study provides basis CHF with ZWD elaborating efficacy, theoretical basis, underlying mechanism prescription. Based on research methods judgment quality markers(Q-markers) medicine, Q-markers were predicted...

Background Alveolar Rhabdomyosarcoma is a profoundly malignant soft-tissue sarcoma that predominantly affects children and adolescents. However, the medical field lacks consensus regarding optimal surgical approach to be undertaken in cases where this tumor causes local bone destruction upper limb. Case description A 17-year-old male presented mass his left forearm CT MRI indicated had penetrated ulnar cortex infiltrating medulla, resulting formation of an eccentric trans-ventricular focus....

Liver transplantation (LT) is one of the most important treatments for children with liver cancer (CLCa) and has been increasingly used. However, there a lack large-scale multicenter studies on trend in application value LT treatment CLCa.We analyzed clinicopathological data CLCa from 2000 to 2018 Surveillance, Epidemiology, End Results (SEER) database. We explored CLCa. LASSO Cox regression Log-Rank test were used explore prognostic factors, we built nomogram using screened factors....