A5027495956- Cardiac Imaging and Diagnostics
- Trace Elements in Health
- Cardiac electrophysiology and arrhythmias
- Pharmacological Effects of Natural Compounds
- Heart Rate Variability and Autonomic Control
- Cardiovascular Function and Risk Factors
- Tissue Engineering and Regenerative Medicine
- COVID-19 Clinical Research Studies
- Cardiac Structural Anomalies and Repair
- Gout, Hyperuricemia, Uric Acid
- PARP inhibition in cancer therapy
- Magnesium in Health and Disease
- SARS-CoV-2 and COVID-19 Research
- Cardiac tumors and thrombi
- Renal Diseases and Glomerulopathies
- Veterinary medicine and infectious diseases
- Magnesium Alloys: Properties and Applications
- Systemic Sclerosis and Related Diseases
- Cardiac Valve Diseases and Treatments
- RNA modifications and cancer
- Transplantation: Methods and Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Cardiomyopathy and Myosin Studies
- Ultrasound and Hyperthermia Applications
- Mitochondrial Function and Pathology
University of Minnesota Medical Center
2024-2025
University of Minnesota System
2019-2025
Shandong University of Traditional Chinese Medicine
2025
Massachusetts General Hospital
2025
General Hospital of Guangzhou Military Command
2025
Guangzhou University of Chinese Medicine
2025
Shandong Academy of Sciences
2024
Qilu University of Technology
2024
University of Minnesota
2016-2023
Mayo Clinic
2020
BACKGROUND: Randomized trials in obstructive coronary artery disease (CAD) have largely shown no prognostic benefit from revascularization. Although there are several potential reasons for the lack of benefit, an underexplored possible reason is presence coincidental nonischemic cardiomyopathy (NICM). We investigated prevalence and significance NICM patients with CAD (CAD-NICM). METHODS: conducted a registry study consecutive on angiography who underwent contrast-enhanced cardiovascular...
The modified Rankin Scale (mRS) is a commonly used functional outcome assessment in stroke clinical trials and has become an essential metric for research. However, the mRS not routinely obtained practice. When necessary, can be derived retrospectively from electronic health record (EHR) documentation review, but this process labor-intensive subjective. Large language models, such as GPT-4, have shown promise automating chart review various outcomes. We developed tested ability of large...
Hyperuricemia (HUA) is a prevalent metabolic disorder associated with chronic disease, posing significant global health challenges. Coix seed, traditional cereal, has shown therapeutic potential against HUA, oligosaccharides serving as its primary active components. However, the mechanisms of seed in HUA management remain underexplored. In this study, novel oligosaccharide was isolated from (CSO) through enzymatic hydrolysis and column chromatography. Structural analysis revealed that CSO...
Abstract Aims Systemic sclerosis (SSc) is a rare autoimmune disorder associated with high risk of cardiovascular diseases. We aimed to determine the long-term prognostic value left and right ventricular (LV RV) systolic dysfunction in SSc patients clinically suspected cardiac disease. Methods Results conducted retrospective cohort study consecutive adults who had magnetic resonance imaging (CMR) for assessed two CMR measures LV RV function, ejection fraction (EF) feature tracking-derived...
<title>Abstract</title> Cardiac complications, including myocardial injury and dysfunction, are common in severe viral respiratory infections (VRI) associated with increased mortality<sup>1–3</sup>. The pathophysiology of VRI-induced is multifactorial, but frequently involves structural damage to the heart’s microvascular network that leads subsequent ischemia dysfunction<sup>4–6</sup>. Currently, there no targeted therapies available prevent or attenuate VRI-associated injury. Moreover,...
BACKGROUND: In heart transplant recipients, right ventricular (RV) dysfunction may occur for a variety of reasons. Whether RV in the stable phase after transplantation is associated with long-term adverse outcomes unknown. We aimed to determine prognostic significance identified on cardiovascular magnetic resonance imaging (CMR) at least 1 year transplantation. METHODS: consecutive recipients who underwent CMR surveillance, we assessed 2 measures function: ejection fraction and global...
Chronic hypertension (HTN) affects more than 1 billion people worldwide, and is associated with an increased risk of cardiovascular disease. Despite decades promising research, effective treatment HTN remains challenging. This work investigates vagus nerve stimulation (VNS) as a novel, device-based therapy for treatment, specifically evaluates its effects on long-term survival HTN-associated adverse effects. was induced in Dahl salt-sensitive rats using high-salt diet, the were randomly...
Paroxysmal atrial fibrillation (Paro. AF) is challenging to identify at the right moment. This disease often undiagnosed using currently existing methods. Nonlinear analysis gaining importance due its capability provide more insight into complex heart dynamics. The aim of this study use several recently developed nonlinear techniques discriminate persistent AF (Pers. from normal sinus rhythm (NSR), and importantly, Paro. NSR, short-term single-lead electrocardiogram (ECG) signals....
Abstract Aims Current management of left ventricular (LV) thrombus relies on limited, non-contemporary, echocardiography-based studies. Data LV evolution and the associated embolic risk are scarce. We aimed to describe serial cardiovascular magnetic resonance imaging (CMR)—the current reference standard for detection thrombus—and identify correlates no resolution with status. Methods results conducted a retrospective cohort study 107 consecutive patients who had 213 CMRs at median 255 days...
Background: We have previously demonstrated that diabetes mellitus (DM) causes cardiac inflammation leading to heart failure with preserved ejection fraction (HFpEF). Arachidonate 5-lipoxygenase (5-LOX), encoded by the ALOX5 gene, is an enzyme highly expressed in leukocytes. 5-LOX synthesizes specialized pro-resolving mediators (SPMs) including Resolvin D1 (RvD1), which reduce inflammation. Hypothesis: hypothesize cardiac-specific upregulation could prevent diabetes-associated HFpEF without...
Introduction: Randomized trials in obstructive coronary artery disease (CAD) have largely shown no prognostic benefit from revascularization. While there are several potential reasons for the lack of revascularization, an underexplored possibility is presence coexisting nonischemic myocardial pathology. Aim: We aimed to investigate prevalence and significance cardiomyopathy (NICM) CAD. Methods: studied a large cohort consecutive patients with CAD on angiography who had cardiovascular...
The Y chromosome male-specific region known as the MSY comprises approximately 95% of DNA content chromosome. Based on few chromosomes that have been sequenced, it has determined its euchromatic contains at least four different types sequences: X-transposed (99% similarity with X), X-degenerate (60–96% to ampliconic and centromere repetitive sequences. Y-chromosome genes, are single copy, an X counterpart (sequence homolog) largely housekeeping genes broad expression profiles, or in some...
Introduction The “leaky” gain-of-function mutations of the ryanodine receptor type 1 (RyR1) are linked to skeletal muscle disorders, including malignant hyperthermia (MH), which occurs in response particular medications used during general anesthesia. In addition a severe reaction anesthetic drugs, sudden cardiac death (SCD) MH patients has been also reported occur non-anesthesia conditions. However, molecular mechanism SCD associated with remains unresolved. Although major RyR isoform...
Introduction COVID-19 caused by SARS-CoV-2 is an ongoing global health emergency. Pre-existing cardiovascular diseases (CVD) including hypertension have a higher risk for severe illness, cardiac damage, and death. Therefore, strategies protection in are urgently needed, addition to the development of vaccines against COVID-19. Previously, it has been reported that several SARS-CoV-1 genes encoded Envelope (E) protein, open reading frame (ORF) 3a, capable forming viral channels mammalian...
Introduction: Hypomagnesemia (HypoMg) is commonly observed in heart failure and associated with inflammation. We have reported that inflammation contributes to mitochondrial oxidative stress causes cardiac diastolic dysfunction (DD) diabetic mice Mg supplementation shows therapeutic benefits. Meanwhile, diet-induced HypoMg alone can lead DD. Transient receptor potential melastatin 7 (TRPM7), a transporter kinase domain, regulates homeostasis different types of cells. Object: aim assess the...
Background: Cardiac sarcoidosis (CS) is associated with a high risk of ventricular arrhythmia (VA) and heart failure (HF). Cardiovascular magnetic resonance imaging (CMR) often used for the diagnosis prognostication suspected CS. Small studies have shown promise strain as marker adverse outcomes in Aim: We aimed to investigate prognostic value CMR global longitudinal (GLS) patients Methods: Using retrospective cohort design, we studied consecutive histologically proven who underwent...
Organic trace minerals, Zn in particular, have proven superior at promoting pig health and performance than inorganic mineral diets for pigs. However, the mechanisms involved these differences are not understood. To define if organic sources of trigger different responses intestine, we evaluated expression genes coding nutrient transporters, cytokines mouse enteroids. Enteroids 3-dimensional structures grown vitro that all cell types structure small allowing studies specific epithelial to...