A5101834840- Cancer Cells and Metastasis
- Parathyroid Disorders and Treatments
- Genetic Syndromes and Imprinting
- SARS-CoV-2 and COVID-19 Research
- Heterotopic Ossification and Related Conditions
- Pain Mechanisms and Treatments
- Botulinum Toxin and Related Neurological Disorders
- Renal Transplantation Outcomes and Treatments
- Computational Drug Discovery Methods
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Transcranial Magnetic Stimulation Studies
- Vitamin D Research Studies
- Hippo pathway signaling and YAP/TAZ
- Hepatocellular Carcinoma Treatment and Prognosis
- Extracellular vesicles in disease
- Tendon Structure and Treatment
- MRI in cancer diagnosis
- Blood properties and coagulation
- Nanoplatforms for cancer theranostics
- Cancer Mechanisms and Therapy
- Radiomics and Machine Learning in Medical Imaging
- Osteoarthritis Treatment and Mechanisms
- Reproductive Biology and Fertility
- Mechanisms of cancer metastasis
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
Chongqing Cancer Hospital
2020-2024
Chongqing University
2020-2024
The First Affiliated Hospital, Sun Yat-sen University
2012-2024
Sun Yat-sen University
2012-2024
BGI Research
2023
Shanghai Normal University
2023
BGI Group (China)
2023
Nanchang University
2021-2023
Qingdao University
2021-2022
Abstract Head and neck squamous cell carcinomas (HNSCCs) harbor a subset of cells that are CD44(+) present with malignancy radiotherapy resistance. As key regulator self-renewal, Nanog expression not only determines fate in pluripotent but also mediates tumorigenesis cancer cells; thus, we examined the role HNSCC. Three HNSCC lines, tumor xenografts, patient tumors were examined. levels significantly higher spheroids than CD44(−) spheroids, further increased when grown as to enrich for CSCs....
The recent coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome 2 (SARS-CoV-2), has exerted considerable impact on global health. To prepare for rapidly mutating viruses and the forthcoming effective therapies targeting critical stages of viral life cycle need to be developed. Viruses are dependent interaction between receptor-binding domain (RBD) Spike (S) protein (S-RBD) angiotensin-converting enzyme (ACE2) receptor efficiently establish infection...
ABSTRACT Cathepsin L (CTSL) could cleave and activate SARS-CoV-2 Spike protein to promote viral entry, making it a hopeful therapeutic target for COVID-19 prevention treatment. So CTSL inhibitors are considered be promising strategy infection. has previously been expressed in inclusion body Escherichia coli. In order prepare with high purity activity soluble active form, we transformed HEK-293T cells recombinant mammalian expression plasmid. was purified about 95%, found migrate at...
Methotrexate (MTX) is widely used to treat cancers and systemic autoimmune diseases. However, it severely toxic healthy cells, especially those of the reproductive system, therefore poses a great risk patient fertility. In addition, underlying mechanism MTX-induced toxicity has not yet been fully elucidated. Here, spermatocyte cell line (GC2) was as an in vitro model system determine whether MTX induces autophagy apoptosis, elucidate role reactive oxygen species (ROS) Ca2+ these two...
Cathepsin L (CTSL), a lysosomal cysteine proteinase, is primarily dedicated to the metabolic turnover of intracellular proteins. It involved in various physiological processes and contributes pathological conditions such as viral infection, tumor invasion metastasis, inflammatory status, atherosclerosis, renal disease, diabetes, bone diseases, other ailments. The coronavirus disease 2019 (COVID-19), with its rapid global spread significant mortality, has been worldwide epidemic since late...
Arthritis is the most common cause to lead chronic pain. Botulinum toxin type A (BoNT/A) has been widely used treat In our previous study, we confirmed anti-inflammatory and antinociceptive effects of BoNT/A in Complete Freund's Adjuvant (CFA)-induced arthritis model, but underlying mechanism was not fully elucidated. The purpose this study investigate mechanisms on using transcriptomic analysis. injected into rat ankle joint day 21 after CFA injection. von Frey hot plate tests were applied...
Diabetic nephropathy (DN) is one of the most prevalent complications diabetes mellitus (DM). However, there still a lack effective methods for non-invasive diagnosis DN in clinical practice. We aimed to explore biomarkers from plasma cell-free DNA as surrogate renal biopsy differentiation patients with DM. The (cfDNA) was sequenced 53 healthy individuals, DM but without DN, and 71 both DN. Multidimensional features were analyzed dissect cfDNA profile identify DN-specific features. Finally,...
Abstract Background: This study aims to evaluate the therapeutic effect of intra-articular injection different doses exosomes derived from mesenchymal stem cells(MSC) and on nerve cartilage repair in a monoiodoacetate (MIA) model knee osteoarthritis(OA) rats. Methods: The pain rat was established by sodium monoiodate into joint rats, dorsal root ganglion (DRG) rats were collected for histologic analyses. For assessment, On 1 day before MIA injection, 7, 14 days after 14,28 Exosome...