A5100403077- Pain Mechanisms and Treatments
- Sinusitis and nasal conditions
- Head and Neck Surgical Oncology
- Botulinum Toxin and Related Neurological Disorders
- Oral and Maxillofacial Pathology
- Bone Tumor Diagnosis and Treatments
- Transcranial Magnetic Stimulation Studies
- Cancer-related gene regulation
- Gout, Hyperuricemia, Uric Acid
- Advanced Glycation End Products research
- Inflammasome and immune disorders
- Neuropeptides and Animal Physiology
- Esophageal and GI Pathology
- Sirtuins and Resveratrol in Medicine
- Infectious Diseases and Tuberculosis
- Microbial metabolism and enzyme function
- Ion Channels and Receptors
- Pituitary Gland Disorders and Treatments
- Fibroblast Growth Factor Research
- Advancements in Transdermal Drug Delivery
- Medicinal Plants and Bioactive Compounds
- Effects of Radiation Exposure
- Neurological Disease Mechanisms and Treatments
- Advanced Nanomaterials in Catalysis
- Pediatric Hepatobiliary Diseases and Treatments
Affiliated Hospital of Qingdao University
2014-2025
Qingdao University
2014-2025
China Medical University
2023
Wannan Medical College
2022
Guangzhou University of Chinese Medicine
2019
Hangzhou First People's Hospital
2017
Wenzhou Medical University
2013
Dalian Municipal Central Hospital
2009
Sinonasal inverted papilloma (SNIP) has a risk of malignant transformation into SNIP with squamous cell carcinoma (SNIP-SCC). Early detection SNIP-SCC is crucial for patient outcomes. This study aimed to evaluate the utility tumor-related hematological indices in early diagnosis and develop nomogram incorporating imaging clinical features. included 159 patients (n = 34) or without 125) SCC. Univariate multivariate logistic regression analyses were employed identify independent factors...
Considerable evidences have indicated that elevated uric acid (UA) was involved in renal tubular injury leading to hyperuricemic nephropathy (HN). Scutellarin is a biologically active flavonoid derived from the Chinese traditional herb Erigeron breviscapus Hand-Mazz, which has been widely used treatment of cardiovascular and cerebrovascular diseases. In present study, we analyzed effect scutellarin on HN, by using C57BL/6 mice human epithelial cell line HK-2 subjected adenine/potassium...
The tachykinins substance P and neurokinin A (NKA) are implicated in the pathophysiology of asthma.We tested safety, tolerability, pharmacologic biological efficacy a tachykinin NK(1)/NK(2) receptor antagonist, AVE5883, patients with asthma two double-blind, placebo-controlled crossover studies.The single inhaled dose (4.8 mg) AVE5883 was against NKA 20 asthma. Subsequently, we studied pharmacologically effective on allergen multiple-dose trial mg three times per day, 9 d) 12 dual responses...
C-phycocyanin (C-PC) is an effective antioxidant and has important value in medical research. Oxidative stress considered to be one of the main underlying mechanisms cell death, reducing oxidative strategies enhance germ viability. Herein, we investigated protective effect mechanism C-PC apo-phycocyanin subunit on damage induced by H2 O2 GC-1 spg cells. genes were cloned into pGEX-4T-1 vectorand transformed Escherichia coli BL21 achieve efficient expression subunit. cells treated with 600 μM...
Acute kidney injury (AKI) results in high morbidity and mortality among inpatients, while effective treatment intervention are still absent. Therefore, this study aims to explore the effects of Scutellarin (Scu) experimental models vivo vitro.In experiment, we employed a total 30 Wistar rats, which further were modelled by bilateral renal pedicle clip for 45 min, then received 50 mg/kg/day Scu. In vitro, HK-2 cells administered with 20μΜ Scu incubated hypoxia/reoxygenation (H/R) conditions...
Objectives Sinonasal inverted papilloma (SNIP) is a noncancerous tumor that develops in the mucous membrane of nasal sinuses. Many malignancies are tightly linked to autophagy, an intracellular self‐degradation mechanism. HMGB1 has demonstrated its ability modulate autophagy many pathological conditions. This work investigates how and other genes involved contribute SNIP. Material Methods The study included 45 patients with SNIP control group consisting 28 individuals. In each group, qPCR...
Abstract Background The development of neuropathic pain (NP) is one the reasons why difficult to treat, and microglial activation plays an important role in NP. Recently, platelet-rich plasma (PRP) has emerged as a novel therapeutic method for knee osteoarthritis (KOA). However, it’s unclarified whether PRP analgesic effects on NP induced by KOA underlying mechanisms unknown. Purpose To observe explore potential alleviating Methods was male rats with intra-articular injections monosodium...
Arthritis is the most common cause to lead chronic pain. Botulinum toxin type A (BoNT/A) has been widely used treat In our previous study, we confirmed anti-inflammatory and antinociceptive effects of BoNT/A in Complete Freund's Adjuvant (CFA)-induced arthritis model, but underlying mechanism was not fully elucidated. The purpose this study investigate mechanisms on using transcriptomic analysis. injected into rat ankle joint day 21 after CFA injection. von Frey hot plate tests were applied...
Limited information is available concerning the epidemiology of Toxoplasma gondii infection in children with leukemia Eastern China. Therefore, a case-control study was conducted to estimate seroprevalence toxoplasmosis this patient group and identify risk factors possible routes infection. Serum samples were collected from 339 age matched health control subjects Qingdao September 2014 March 2018. Enzyme linked immunoassays used screen anti- T. IgG IgM antibodies. Forty-eight (14.2%) 31...
One-dimensional (1D) nanomaterials are widely used in different fields, and the increased application of 1D has drawn concerns about their unknown toxicity. titanium oxide (TiO2) crystal phases commonly applied environmental remediation solar energy conversion but these materials pose a threat to human health, especially kidneys, an organ with abundant blood flow. To systematically evaluate cytotoxicity TiO2 nanofibers TiO2(B), anatase, rutile phases, as well nanorods anatase were...
Cognitive impairment has been described in elderly subjects with high normal concentrations of serum uric acid. However, it remains unclear if gout confers an increased poorer cognition than those individuals asymptomatic hyperuricemia. The present study aimed at evaluating cognitive function patients suffering from male population, and further investigating the genetic contributions to risk function. This examined as assessed by Mini-Mental State Examination (MMSE) Montreal Assessment...
Objectives To investigate the expression of eukaryotic initiation factor 4 E (eIF4E) in hypopharyngeal carcinoma compared with benign lesions, and relationships between eIF4E various clinicopathological parameters. Methods Expression was analysed retrospectively specimens from carcinomas lesions using immunohistochemical staining Western blotting. Tumours were classified tumour–node–metastasis staging system degree histological differentiation assessed. Results A total 55 20 analysed. All...