A5101562437- Medicinal Plants and Neuroprotection
- Functional Brain Connectivity Studies
- Nanoparticles: synthesis and applications
- Advanced MRI Techniques and Applications
- Spinal Cord Injury Research
- Allelopathy and phytotoxic interactions
- Advanced Neuroimaging Techniques and Applications
- Cassava research and cyanide
- Phytochemicals and Antioxidant Activities
- Heavy Metals in Plants
- Bone and Joint Diseases
- Traditional Chinese Medicine Analysis
- Plant Stress Responses and Tolerance
- Assisted Reproductive Technology and Twin Pregnancy
- Traditional Chinese Medicine Studies
- Metabolomics and Mass Spectrometry Studies
- Bone health and treatments
- Pregnancy and preeclampsia studies
- Head and Neck Surgical Oncology
- Spinal Fractures and Fixation Techniques
- Gut microbiota and health
- Bioactive natural compounds
- Medicinal Plant Pharmacodynamics Research
- Hypothalamic control of reproductive hormones
- Neurological Disease Mechanisms and Treatments
Huaihua University
2024-2025
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2014-2025
Qingdao University
2017-2024
Affiliated Hospital of Qingdao University
2017-2024
Shandong University of Traditional Chinese Medicine
2024
Tongji Hospital
2024
Guangdong Medical College
2024
Hebei Medical University
2024
Xingtai People's Hospital
2024
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron sublineages BA.2.12.1, BA.4 and BA.5 exhibit higher transmissibility than the BA.2 lineage 1 . The receptor binding immune-evasion capability of these recently emerged variants require immediate investigation. Here, coupled with structural comparisons spike proteins, we show that (BA.4 are hereafter referred collectively to as BA.4/BA.5) similar affinities for angiotensin-converting enzyme (ACE2) receptor. Of note,...
Because copper nanoparticles are being increasingly used in agriculture as pesticides, it is important to assess their potential implications for agriculture. Concerns have been raised about the bioaccumulation of nano-Cu and toxicity crop plants. Here, response cucumber plants hydroponic culture at early development stages two concentrations (10 20 mg/L) was evaluated by proton nuclear magnetic resonance spectroscopy (1H NMR) gas chromatography–mass spectrometry (GC-MS) based metabolomics....
There has been an increasing influx of nanopesticides into agriculture in recent years. Understanding the interaction between and edible plants is crucial evaluating potential impact nanotechnology on environment agriculture. Here we exposed lettuce to Cu(OH)2 (1050–2100 mg/L) through foliar spray for one month. Inductively coupled plasma-mass spectrometry (ICP-MS) results indicate that 97–99% (1353–2501 mg/kg) copper was sequestered leaves only a small percentage (1–3%) (17.5–56.9...
Abstract The continuous emergence of highly immune evasive SARS-CoV-2 variants, like XBB.1.5 1,2 and XBB.1.16 3,4 , highlights the need to update COVID-19 vaccine compositions. However, imprinting induced by wildtype (WT)-based vaccination would compromise antibody response Omicron-based boosters 5-9 . Vaccination strategies that can counter are critically needed. In this study, we investigated degree dynamics in mouse models human cohorts, especially focusing on role repeated Omicron...
While the use of nanopesticides in modern agriculture continues to increase, their effects on crop plants are still poorly understood. Here, 4 week old spinach grown an artificial medium were exposed via foliar spray Cu(OH)2 nanopesticide (0.18 and 18 mg/plant) or Cu ions (0.15 15 for 7 days. A gas chromatography-time-of-flight-mass spectrometry metabolomics approach was applied assess metabolic alterations induced by leaves. Exposure copper metabolite profiles Compared control, exposure mg...
The full-length AML1-ETO ( AE ) fusion gene resulting from t(8;21)(q22;q22) in human acute myeloid leukemia (AML) is not sufficient to induce animals, suggesting that additional mutations are required for leukemogenesis. We and others have identified activating of C-KIT nearly half patients with t(8;21) AML. To test the hypothesis cooperate cause overt AML, we generated a murine transduction transplantation model both mutated . overcome intracellular transport block cells, engineered hybrid...
Due to the potential for interactions between crop plants and engineered nanomaterials (ENMs), there is increasing interest in understanding bioavailability effects of ENMs released into soil systems. Here, we investigate influence root exudates on fate from a thermodynamic perspective. Nano isothermal titration calorimetry was applied determine parameters interaction nanocopper (nCu) synthetic exudate (SRE) its components (including sugars, organic acids, amino phenolic acids), as well Cu2+...
Due to their unique properties, copper-based nanopesticides are emerging in the market. Thus, understanding effect on crop plants is very important. Metabolomics can capture a snapshot of cellular metabolic responses stressor. We selected maize and cucumber as model for exposure different doses Cu(OH)2 nanopesticide. GC-TOF-MS-based metabolomics was employed determine these two species. Results revealed significant differences metabolite profile changes between cucumber. Furthermore,...
Nanopesticides are becoming more popular in modern agriculture to improve crop protection product efficacy. However, information on their implications for plants is needed. In this study, 3-week-old maize were exposed different doses of Cu(OH)2 nanopesticide (0, 10, and 100 mg) 7 days via foliar application. Gene expression 9 antioxidant-related enzymes (CAT1, POD1, GST1, SOD-1A, SOD-B, GPX, APX1, HSP1, PER1) was determined using a quantitative real-time polymerase chain reaction. Using gas...
Copper-based nanoparticles have wide application in agriculture as fungicides and bactericides.
A Cu(OH)<sub>2</sub>nanopesticide induced oxidative stress and activated the antioxidant defense system in cucumber plants.
Objective: This study investigates the effects of ginger on sperm dysmorphosis under heat stress using network pharmacology and molecular docking techniques. Methods: The core components, target sites, primary pathways were predicted TCMSP database. Genes associated with malformation identified through databases such as GeneCards DisGeNET, followed by KEGG GO analyses based intersections targets. Core genes via Cytoscape software subjected to ginger’s active components. Results: principal...
Background: Transient ischemic attack (TIA) is an important risk factor for stroke. Despite the transient episodes of clinical symptoms, brain alterations are still observed in patients with TIA. However, functional mechanism ischemia unclear. Here, we employed resting-state magnetic resonance imaging (rs-fMRI) to explore abnormalities Methods: 48 TIA and 41 age- sex-matched healthy controls (HCs) were enrolled study. For each participant, collected rs-fMRI data...
Background: Thyroid autoimmunity (TAI) is the most frequent autoimmune disease among reproductive-aged women. It has been related to premature ovarian insufficiency, but mechanisms remain elusive, and its association with reserve in euthyroid women debatable. Moreover, impact of TAI on assisted reproduction controversial: especially for diminished (DOR), few studies are available. Therefore, present study was aimed look an between DOR, evaluate effect pregnancy outcomes offspring health...