A5029898989- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Uterine Myomas and Treatments
- Cancer-related molecular mechanisms research
- Genetic and Kidney Cyst Diseases
- Kruppel-like factors research
- Renal and related cancers
- Neuroendocrine regulation and behavior
- Ovarian function and disorders
- Pregnancy and preeclampsia studies
- Amino Acid Enzymes and Metabolism
- COVID-19 Impact on Reproduction
- Autism Spectrum Disorder Research
- Hedgehog Signaling Pathway Studies
- Child Development and Digital Technology
International Peace Maternity & Child Health Hospital
2019-2024
Shanghai Jiao Tong University
2019-2024
Shanghai Municipal People's Government
2020-2021
Endometriosis, a chronic disorder characterised by the presence of endometrial-like tissue outside uterus, is associated with iron overload and oxidative stress in lesion. Although it well established that can trigger ferroptosis, results previous studies on ferroptosis resistance endometriotic lesions are paradoxical. Here, we found some stromal cells cyst walls were contact fluid underwent ferroptosis. Surprisingly, endometrial cell triggered production angiogenic, inflammatory growth...
Sperm morphology mainly refers to the shape of head, length flagellar segments, including midpiece, principal piece and end piece, size accessory structures, axonemes, outer dense fibers (ODFs), mitochondrial sheath (MS) fibrous (FS). Across species, there is considerable diversity in morphology. An established theory posits that sperm flagellum, especially a critical factor influencing metabolism velocity. However, our understanding relationships between ultrastructures incomplete. The...
Abstract Adenomyosis is associated with dysmenorrhea, infertility, and lesional fibrosis. The pathogenesis of adenomyosis still unclear. Plasminogen activator inhibitor 1 (PAI-1) plays important roles in pathological activities like tumor metastasis endometriosis. Our objective was to investigate the expression localization PAI-1 eutopic ectopic endometrium without adenomyosis. We also sought determine relationship between immunoreactivity severity dysmenorrhea extent fibrosis significantly...
Accumulating evidence from epidemiological studies of humans and genetic models in rodents has shown that offspring males advanced paternal age (APA) are susceptible to metabolic neurological disorders. However, knowledge molecular mechanism(s) underlying these behavioral changes at the intergeneration trans-generation levels APA is limited. Here, we characterized on glucose cholesterol metabolism, also autism spectrum disorders (ASD)-like behaviors 1st 2nd generations 12- 18-month-old male...
Preeclampsia (PE) is a risk factor for autism spectrum disorder (ASD) in offspring. However, the exact mechanisms underlying impact of PE on progeny ASD are not fully understood, which hinders development effective therapeutic approaches. This study shows offspring born to mouse model treated by N ω -nitro-L-arginine methyl ester (L-NAME) exhibit ASD-like phenotypes, including neurodevelopment deficiency and behavioral abnormalities. Transcriptomic analysis embryonic cortex adult hippocampus...
Abstract Cilia and flagella are critical organelles with conserved internal structures diverse developmental physiological processes according to cell type. Although the core components of shared thousands associated proteins involved in cilia or formation, we hypothesized that some unknown proteins, such as outer dense fiber 2 (Odf2/Cenexin) perform distinct functions these organelles. In present study, identified several uncharacterized through mass spectrometry interactome analysis...
Adenomyosis (AM) is a disease in which endometrial tissue invades the myometrium and has 10–60% prevalence reproductive-aged women. TSC2 regulates autophagy via mTOR1 signalling colorectal cancer carcinoma. Dysregulation of implicated adenomyosis pathogenesis. However, whether participates remains obscure. Here, we found that expression was significantly decreased than normal endometrium during secretory phase. Moreover, marker lower ectopic lesions eutopic samples. downregulation inhibited...