A5100651995- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Endometrial and Cervical Cancer Treatments
- Pregnancy and preeclampsia studies
- Uterine Myomas and Treatments
- Immunotherapy and Immune Responses
- Estrogen and related hormone effects
- Ureteral procedures and complications
- MicroRNA in disease regulation
- Reproductive Physiology in Livestock
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- Musculoskeletal pain and rehabilitation
- Viral Infections and Vectors
- Cervical Cancer and HPV Research
- SARS-CoV-2 and COVID-19 Research
- T-cell and B-cell Immunology
- Gynecological conditions and treatments
- Intracranial Aneurysms: Treatment and Complications
- Rabies epidemiology and control
- RNA Interference and Gene Delivery
- Monoclonal and Polyclonal Antibodies Research
- Management of metastatic bone disease
- Nutrition and Health in Aging
- Nuclear Receptors and Signaling
Environmental and Occupational Health Sciences Institute
2023
Rutgers, The State University of New Jersey
2023
Rutgers Sexual and Reproductive Health and Rights
2023
Shandong University
2020-2023
Obstetrics and Gynecology Hospital of Fudan University
2003-2023
National Institute for Viral Disease Control and Prevention
2022
Chinese Center For Disease Control and Prevention
2022
Guangxi Zhuang Autonomous Region Health and Family Planning
2020
Children's Hospital of Philadelphia
2018
Fudan University
2008-2010
The aim of this study was to evaluate the effect trichostatin A (TSA) in a mouse model endometriosis on serum tumour necrosis factor α (TNFα) levels, hotplate latency, lesion size and immunoreactivity Trpv1, Pkcε Pgp9.5. We used 30 adult female mice, induced by auto-transplanting pieces uterus (ENDO) or fat (SHAM) peritoneum lower parts abdominal pelvic cavity. Two weeks later, ENDO group further divided into two groups randomly: one received TSA treatments other injections dimethyl...
Preeclampsia is associated with developmental delay in infants and an increased risk of various diseases adulthood, including hypertension epilepsy. It has been reported that several organs show retardation functional deficiency offspring preeclamptic rats. However, the changes brains rats remain unknown. Here, we established a preeclampsia-like rat model induced using Nω-nitro-L-arginine methyl ester (L-NAME) to analyze offspring. Body brain weights were decreased L-NAME group at postnatal...
Growth differentiation factor 15 (GDF15) is a secreted protein with pleotropic functions from the transforming growth β (TGF-β) family. GDF15 synthesized as precursor and undergoes proteolytic cleavage to generate mature GDF15. The strong appetite-suppressing effect of makes it an attractive therapeutic agent/target for diseases such obesity cachexia. In addition, clinical studies indicate that circulating, independent biomarker heart failure. We recently found heart-derived hormone inhibits...
Preeclampsia (PE) is a risk factor for autism spectrum disorder (ASD) in offspring. However, the exact mechanisms underlying impact of PE on progeny ASD are not fully understood, which hinders development effective therapeutic approaches. This study shows offspring born to mouse model treated by N ω -nitro-L-arginine methyl ester (L-NAME) exhibit ASD-like phenotypes, including neurodevelopment deficiency and behavioral abnormalities. Transcriptomic analysis embryonic cortex adult hippocampus...
SummaryMedical records of 32 women with abdominal incision endometriosis who underwent surgical treatment in the Obstetrics and Gynaecology Hospital at Fudan University between September 1999 March 2006 were reviewed retrospectively. All cases concerning diagnosis confirmed by two gynaecological pathologists. The median age was years (range from 25 to 45). A total 31 patients had a history caesarean section, one case ovarian endometrioid cystectomy. presented mass scar. Among them, there 30...
Abstract The coronavirus disease 2019 (COVID‐19) pandemic posed great impacts on public health. To fight against the pandemic, robust immune responses induced by vaccination are indispensable. Previously, we developed a subunit vaccine adjuvanted aluminum hydroxide, ZF2001, based dimeric tandem‐repeat RBD immunogen, which has been approved for clinical use. This design was also explored as an mRNA vaccine. Both showed potent immunogenicity. In this study, DNA candidate encoding RBD‐dimer...
Phosphopeptides presented by major histocompatibility complex (MHC) class I have been regarded as a pivotal type of cancer neoantigens that are recognized T cells. The structural basis single-phosphorylated peptide presentation has well studied. Diphosphorylation with one interval between two sites is the prevalent forms multisite-phosphorylated peptides. Herein, we determined molecular P4/P6 double pS-containing peptides HLA-B27 and compared them unmodified complexes. These data clarified...
Background: Haemaphysalis longicornis, a vector of various diseases with medical and veterinary importance, is native to eastern Asia, recently invaded the United States as an emerging disease threat.Methods: We collected multi-source data from field survey, reference book, literature search related websites. Geographic distribution H. longicornis its infected agents was mapped by geographical information system techniques. Hosts infection rates longicornis-borne were estimated...