A5024929407- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Preterm Birth and Chorioamnionitis
- Thyroid Disorders and Treatments
- Gestational Diabetes Research and Management
- Congenital Heart Disease Studies
- Reproductive System and Pregnancy
- Microbial Natural Products and Biosynthesis
- Infant Nutrition and Health
- Carbohydrate Chemistry and Synthesis
- Prenatal Screening and Diagnostics
- Pregnancy-related medical research
- Maternal and fetal healthcare
- Neonatal Respiratory Health Research
- Congenital heart defects research
- Peroxisome Proliferator-Activated Receptors
- Folate and B Vitamins Research
- Ovarian function and disorders
- Wnt/β-catenin signaling in development and cancer
- Congenital Diaphragmatic Hernia Studies
- Analytical Chemistry and Chromatography
- Bone Metabolism and Diseases
- Physiological and biochemical adaptations
- Epigenetics and DNA Methylation
- Blood Coagulation and Thrombosis Mechanisms
Chengdu Institute of Biology
2024
Chinese Academy of Sciences
2024
Chengdu University
2024
Obstetrics and Gynecology Hospital of Fudan University
2013-2024
Nanjing University
2024
Shanghai Changning Maternity and Infant Health Hospital
2024
East China Normal University
2024
Hunan University of Traditional Chinese Medicine
2019
Fudan University
2010-2015
Jinan Maternity And Care Hospital
2006
Folic acid (FA) supplementation is associated with a lower risk of the neural tube and heart defects recommended for women childbearing age. Although there are detailed recommendations, differences in initiation time duration FA remain poorly studied.
Preeclampsia (PE) is a severe pregnancy-induced disorder characterized by hypertension and proteinuria leading cause of perinatal maternal–fetal mortality morbidity in developing countries. Dysregulated human leukocyte antigen (HLA)-G was found placentas as well maternal sera from PE patients; however, the reason for this difference unknown. As accumulating evidence has confirmed that DNA methylation an important mechanism regulating gene expression, we sought to test hypothesis alteration...
Evidence for the association between maternal thyroxine concentration and risk of fetal congenital heart defects (CHDs) is absent. We aimed to study free total (FT4 TT4) concentrations free-to-total proportion (FTT4P, %) with CHD.The was a hospital-based cohort 52,047 women who received universal thyroid function test 2012 2016. CHD screened by ultrasound 20 24 weeks gestation or diagnosed until 42nd day birth. Adjusted odds ratios (ORs) were estimated FT4 TT4 FTT4P multivariate logistic...
Preterm labour is a common pregnancy complication contributing to major maternal and fetal morbidity mortality. We have found microRNA (miR)-212-3p, potential infection-associated molecule, was significantly over-expressed during human preterm labour. However, the mechanism remains unknown. In this study, we adopted lipopolysaccharide (LPS)-induced Institute of Cancer Research murine model examine role miR-212-3p in infection-induced Myometrial expression increased by nearly 4-fold term...
Abstract Background A lack of information on specific and interventional factors for stillbirth has made designing preventive strategies difficult, the rate declined more slowly than neonatal death rate. We compared prevalence among offspring women with or without abnormal placental perfusion (APP). Methods conducted a hospital-based retrospective cohort study involving singleton pregnancy between 2012 2016 ( N = 41,632). Multivariate analysis was performed to compare in infants exposed APP...
Abstract Background The effect and extent of abnormal placental perfusion (APP) on the risk male hypospadias are poorly understood. We compared prevalence in offspring women with APP quantify anomaly. Methods A hospital-based retrospective analysis births from 2012 to 2016 was conducted 2018. Women singleton pregnancy infants born them were included ( N = 21,447). multivariate performed compare exposed those that not APP. Results Compared without APP, showed an increased (odds ratio, 2.40;...
Objective: The aim of this study was to investigate the role hemostatic factors in pathogenesis preeclampsia. Materials and Methods: Maternal cord plasma concentrations tissue factor (TF), pathway inhibitor (TFPI), von willebrand (vWF), soluble P-selectin (sP-selectin), fibrinopeptide A (FPA), D-dimer, antithrombin III (AT-III) were measured by enzyme-linked immunosorbent assay (ELISA) 46 women with preeclampsia 40 normotensive pregnant before after delivery. Results: maternal TF, vWF,...
The cultivation of Streptomyces tauricus NA06920 has yielded three krisynomycin-type peptides. structures these compounds were characterized through spectroscopic analysis and LC-MS interpretation. Krisynomycins are by the presence various modification residues, including N-malonylated alanine, cysteic acid, prenylated tryptophan. Bioinformatic sequencing revealed biosynthetic gene cluster for compounds, subsequent in vivo vitro experiments confirmed function KsnA as trans-acting tryptophan...
Abstract Persistent and intense uterine contraction is a risk factor for preterm labor. We previously found that methyl-CpG-binding protein 2 (MeCP2), as target of infection-related microRNA miR-212-3p, may play an inhibitory role in regulating myometrium contraction. However, the molecular mechanisms by which MeCP2 regulates myometrial are still unknown. In this study, we expression was lower specimens obtained from labor cases, compared to those term cases. Herein, using RNA sequence...
The aim of this study was at detecting the expression peroxisome proliferator-activated receptor γ (PPARγ) in patients with gestational diabetes mellitus (GDM) and to investigate whether PPARγ regulates lipid metabolism maternal-fetal interface cells.We detected maternal plasma, fetal plasma amniotic fluid two groups women GDM or normal pregnancy using ELISA western blot. Establish cell models indirect coculture model separate culture BeWo cells endometrial stromal (ESCs). Oil red O staining...
Abstract Background Evidence for the association of thyroid dysfunction and autoantibody positivity with preterm birth remains controversial. We aimed to study maternal risk birth. Method A hospital-based cohort 40,214 women was conducted. Gestational age-specific percentiles FT4 TSH concentrations were used definition dysfunction. Autoantibody identified when concentration > threshold. The estimated. Results No significant higher found variants or positive than euthyroid women....
Abstract Objective: To characterize and compare the microbiome signature in maternal, intrauterine, fetal environments associated bacterial species women who experienced preterm birth term birth. Methods: A total of 140 with singleton pregnancies were enrolled this study. Among them, 31 spontaneous delivery (gestational age < 37 weeks), 28 them vaginal at term. Maternal peripheral blood, saliva, discharge samples membrane, amniotic fluid, cord blood collected immediately after under...
To observe the effects of Zhuang Gu Zhi Tong Formula (ZGZTF) on antagonist SOST in canonical Wnt/β-catenin signaling pathway osteoporosis. We analyzed differential genes patients with osteoporosis and normal subjects from GEO database then found specific expression. as an Wnt by Kyoto Encyclopedia Genes Genomes (KEGG) pathway. Then we studied effect ZGZTF Osteoporosis model was induced ovariectomy (OVX) 8-week-old female Sprague–Dawley (SD) rats. After 12 weeks treatment intragastric...