A5048840331- Sexual Differentiation and Disorders
- Microbial Natural Products and Biosynthesis
- Neonatal Health and Biochemistry
- Liver Disease Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Genomic variations and chromosomal abnormalities
- Prenatal Screening and Diagnostics
- Hormonal and reproductive studies
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Bacteriophages and microbial interactions
- Blood properties and coagulation
- Metabolism and Genetic Disorders
- Amino Acid Enzymes and Metabolism
- Synthetic Organic Chemistry Methods
- Metabolomics and Mass Spectrometry Studies
- Hepatitis B Virus Studies
- Biochemical effects in animals
- Fungal Biology and Applications
- Lipid metabolism and disorders
- Bioactive Compounds and Antitumor Agents
- Prostate Cancer Treatment and Research
- Erythrocyte Function and Pathophysiology
- Nuclear Structure and Function
- Muscle and Compartmental Disorders
- Nasal Surgery and Airway Studies
Nanjing Medical University
2025
China Medical University
2021-2023
Liaoning Cancer Hospital & Institute
2022
Chongqing University
2021
Hunan University of Traditional Chinese Medicine
2019
Mayo Clinic in Arizona
2019
Beijing Tsinghua Chang Gung Hospital
2018
Tsinghua University
2018
Yunnan University
2012-2015
University of Minnesota Rochester
2013
Although retinitis pigmentosa (RP) is the most common type of hereditary retinal dystrophy, approximately 25%-45% cases remain without a molecular diagnosis. von Willebrand factor A domain containing 8 (
Two new compounds, isostreptazolin (1) and sannaphenol (2), were isolated from the culture broth of Streptomyces sannanensis their structures elucidated on basis 1D 2D NMR as well MS, IR UV spectroscopic data analysis. The cytotoxic activity 1 2 evaluated. Both compounds inactive against H460 HeLa cell lines at 100 mM.
Abstract Background Kallmann syndrome (KS) is a common type of idiopathic hypogonadotropic hypogonadism. To date, more than 30 genes including ANOS1 and FGFR1 have been identified in different genetic models KS without affirmatory genotype–phenotype correlation, novel mutations found. Methods A total 35 unrelated patients with clinical features disorder sex development were recruited. Custom-panel sequencing or whole-exome was performed to detect the pathogenic mutations. Sanger verify...
Clonal eosinophilic disorders are rare among hematological malignancies. Most eosinophilia tends to be due secondary causes such as infections, hypersensitivity conditions, drug reactions, and connective tissue disorders. The presence of a primary clonal disorder chronic leukemia-not otherwise specified (NOS) in the synchronous large cell lymphoma-is making diagnosis challenging. We present case 51-year-old female with aforementioned presentation demonstrate extensive workup performed...
Preparation of HIV-1 Env protein and development ultrasensitive detection method gp41 antibody are challengeable tasks for early diagnosis patients with HIV virus. The env gene fragments were obtained from the plasmid by PCR, cloned into T vector, then sequenced. linear prepared Rapid Translation System (RTS) Linear Template Kit, proteins RTS purified magnetic bead method. protein's bioactivity was identified Western Blotting. labeled CdTe quantum dots (QDs), goat anti-HIV-1 IgG antibodies...
To observe the effects of Zhuang Gu Zhi Tong Formula (ZGZTF) on antagonist SOST in canonical Wnt/β-catenin signaling pathway osteoporosis. We analyzed differential genes patients with osteoporosis and normal subjects from GEO database then found specific expression. as an Wnt by Kyoto Encyclopedia Genes Genomes (KEGG) pathway. Then we studied effect ZGZTF Osteoporosis model was induced ovariectomy (OVX) 8-week-old female Sprague–Dawley (SD) rats. After 12 weeks treatment intragastric...
5p deletion syndrome, that characterized by cat-like cry and peculiar timbre of voice, is believed to be one the most common pathogenic copy number variations (CNVs). Variable critical regions on involving a variety genes contribute phenotypic heterogeneity without specific correlation. The objective this study was examine genotype-phenotype correlation redefine syndrome relevant regions. In addition, we demonstrate potential use whole genome sequencing (WGS) identify chromosomal breakpoints...
To assess the value of multiplex ligation-dependent probe amplification (MLPA) for genetic and prenatal diagnosis Duchenne/Becker muscular dystrophy (DMD/BMD).Forty seven patients clinically diagnosed or suspected with DMD/BMD were recruited. Deletion duplication 79 exons DMD gene detected by MLPA. PCR sequencing used to detect single exon deletion. MLPA was also identifying carriers. For cases requesting diagnosis, short tandem repeat (STR) capillary electrophoresis, linkage analysis...
To analyze the non-invasive indexes for predicting esophageal varices (EV) in liver cirrhosis, and to establish a model degree of EV.A total 294 patients with cirrhosis portal hypertension were divided into following groups according EV grade as assessed by endoscopy: non-EV I EV, II III EV. The predictive measures stiffness (LS), platelet (PLT) count, spleen thickness (ST), PLT/ST ratio, vein diameter, flow velocity Child-Pugh score (CPS) univariate analysis multivariate logistic regression...
To carry out cyto- and molecular genetic analysis for a fetus with ring chromosome identified through non-invasive prenatal testing (NIPT).A pregnant woman presented at the Shengjing Hospital Affiliated to China Medical University on May 11, 2021 was selected as study subject. Maternal peripheral blood sample screened by NIPT, G-banded chromosomal karyotyping carried amniotic fluid samples from couple. The were also subjected genomic copy number variation sequencing (CNV-seq), microarray...
Abstract Serum Amyloid A (SAA) is an acute-phase protein, released predominantly from the liver during large scale inflammation. High SAA levels, up to 1000 times normal, are also associated with autoimmune conditions like Rheumatoid Arthritis (RA). found in very high levels arthritic joints of patients, along a concentration certain subsets T lymphocytes, notably helper cell type 1 (Th1). The marker for Th1 cells production cytokine interferon gamma (IFNγ). purpose this study determine if...