A5022951085- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Thyroid Disorders and Treatments
- Assisted Reproductive Technology and Twin Pregnancy
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Neonatal and fetal brain pathology
- Parvovirus B19 Infection Studies
- Neonatal Health and Biochemistry
- Growth Hormone and Insulin-like Growth Factors
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Bariatric Surgery and Outcomes
- Blood Pressure and Hypertension Studies
- Autoimmune and Inflammatory Disorders Research
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Metabolism and Genetic Disorders
- Adolescent and Pediatric Healthcare
- Preterm Birth and Chorioamnionitis
- Cytomegalovirus and herpesvirus research
- Coffee research and impacts
- Down syndrome and intellectual disability research
Obstetrics and Gynecology Hospital of Fudan University
2013-2025
Anhui Medical University
2025
Fudan University
2016-2023
State Key Laboratory of Oncogene and Related Genes
2014-2023
Zhengzhou University
2022
Shenzhen University Health Science Center
2018-2022
UiT The Arctic University of Norway
2016-2021
Shenzhen Luohu People's Hospital
2018
Fetal growth restriction (FGR) is a major determinant of perinatal morbidity and mortality. Our study aimed to develop prediction model for the risk FGR developing adverse outcome (APO) evaluate its performance. This was prospective observational cohort consecutive singleton gestations meeting ACOG-endorsed criteria from January 2022 June 2023 at Obstetrics Gynecology Hospital Fudan University. Clinical information, ultrasound indicators serum biomarkers were collected. The primary composite...
BackgroundPreeclampsia is a devastating hypertensive disorder of pregnancy with unknown mechanism. Recent studies have considered abnormal autophagy as new cellular mechanism for this disorder, while little known about how specifically involved and what factors are implicated. Here, we report previously unrecognized preeclampsia-associated autophagic regulator, PKCβ, that in placental angiogenesis.MethodsPKCβ levels were evaluated by quantitative real-time PCR, western blotting,...
Preeclampsia is regarded as an evolution-related disease that has only been observed in humans and our closest relatives, the important factor contributing to its pathogenesis endothelial dysregulation secondary a stressed placenta. Hypoxia-inducible 1 subunit alpha (HIF1α), highly conserved molecule virtually all mammals, crucial regulator of hypoxia adaptation evolution. Persistent high expression HIF1α placenta one pathogenic mechanisms preeclampsia. Therefore, human-specific molecules...
Abstract Background Gestational age (GA) is associated with later cognition and behavior. However, it unclear how specific cognitive domains brain structural development varies the stepwise change of gestational duration. Methods This large-scale longitudinal cohort study analyzed 11,878 early adolescents’ volume maps at 9–10 years (baseline) 5685 11–12 (a 2-year follow-up) from Adolescent Brain Cognitive Development (ABCD) study. According to age, adolescents were divided into five...
Altered maternal serum lipid metabolism is associated with hypertensive disorders in pregnancy (HDP). However, its range and characteristic among different subgroups of HDPs are unclear. Pregnant women HDP who underwent antenatal care delivered Obstetrics Gynecology Hospital Fudan University during January 2018 to August 2022 were enrolled. The levels total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDLC), low-density (LDLC), apolipoprotein (Apo)-A, B, E, free fatty...
To clarify whether preconception paternal smoking has any adverse effects on the offspring.Prospective, population-based study.Preconception registry data from National Free Preconception Health Examination Project.Couples planning pregnancy, with complete information behaviour and pregnancy outcomes.The effect of questionnaire-based during was assessed via logistic regression. Additionally, we performed a 1:1 case-control (birth defects versus normal pregnancy) analysis, matched for...
Preeclampsia, defined as a hypertensive disorder during pregnancy, is major cause of maternal and fetal mortality. Observational studies have shown that the exposure per- polyfluoroalkyl substances, such perfluorooctane sulfonate (PFOS), emerging significant environmental factor associated with preeclampsia risk. However, epidemiologic evidence correlative in nature, unable to establish causal relationship. Here, we established an animal model PFOS-induced explore molecular mechanism PFOS...
microRNAs (miRNAs) are important both in early cardiogenesis and the process of heart maturation. The aim this study was to determine stage-specific expression miRNAs human fetal order identify valuable targets for further defects. Affymetrix microarrays were used obtain miRNA profiles from tissue at 5, 7, 9 23 weeks gestation. To differentially expressed each time-point, linear regression analysis by R limma algorithm employed. Hierarchical clustering conducted with Cluster 3.0 software....
To investigate potential roles of inducible nitric oxide synthase (iNOS) and apolipoprotein (apoE) in inflammation apoptosis promoting pathological changes preeclampsia pregnant mice with apoE and/or iNOS knock out.B6.129 were crossed to produce WT, apoE(-/-), apoE(+/-), iNOS(-/-), iNOS(+/-) apoE(-/-)iNOS(-/-) groups. Variants confirmed by PCR. Serum lipid parameters (triglycerides, TG; total cholesterol, TC; high density lipoprotein, HDL; low LDL), NO levels placental electronic microscopic...
ABSTRACT Objective This study aimed to identify candidate protein biomarkers from maternal serum for Down syndrome (DS) by integrated proteomic and bioinformatics analysis. Methods A pregnancy DS group of 18 women a control with the same number were prepared, proteins analyzed isobaric tags relative absolute quantitation mass spectrometry, differentially expressed (DS‐DEMSPs). Comprehensive analysis was then employed analyze DS‐DEMSPs both in this paper seven related publications. Results...
Objective: Magnesium sulfate is used for the treatment of preeclampsia. This study aimed to evaluate effects magnesium on heart rate variability (HRV), blood pressure (BPV) and baroreflex sensitivity (BRS) in pregnant rats treated with NG-nitro-.-arginine-methyl ester (L-NAME). Methods: Sprague–Dawley were randomly divided into four groups: non-pregnancy three groups. From gestational day 2–12, normal pregnancy group (NOR) received sterile water through intravenous injection, LN was injected...
Objective To identify differentially expressed proteins from serum of pregnant women carrying a conotruncal heart defects (CTD) fetus, using proteomic analysis. Methods The study was conducted nested case-control design. 5473 maternal samples were collected at 14–18 weeks gestation. 9 CTD 10 with another CHD (ACHD) and 11 normal fetus selected the above samples, analyzed by isobaric tags for relative absolute quantitation (iTRAQ) coupled two-dimensional liquid chromatography-tandem mass...
The use of low-dose aspirin for women with twin pregnancies remains controversial. This study was to describe the frequency preeclampsia and in real practice. retrospective cohort based on real-world data conducted Obstetrics Gynecology Hospital Fudan University between 2013 2020. Women who received prenatal care before 20 weeks gestational age were included. They divided into those using (LDA group) not group (N-LDA group). primary outcome preeclampsia, secondary outcomes included...
Abstract Introduction Subclinical hypothyroidism (SCH) during pregnancy is reported to have detrimental impact on and child development. However, its treatment indications require further investigation in different thyroid peroxidase antibody (TPOAb) status. Material methods This was a secondary analysis of Chinese prospective cohort real‐world setting. Pregnant women with gestational SCH were enrolled at the first antenatal visit grouped by TPOAb positivity. Child neurodevelopment assessed...