A5063737572- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Antimicrobial Resistance in Staphylococcus
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Circular RNAs in diseases
- Streptococcal Infections and Treatments
- Sleep and related disorders
- Per- and polyfluoroalkyl substances research
- Neonatal Health and Biochemistry
- Thyroid Disorders and Treatments
- Circadian rhythm and melatonin
- Bacterial biofilms and quorum sensing
- Parvovirus B19 Infection Studies
- Sleep and Wakefulness Research
- Assisted Reproductive Technology and Twin Pregnancy
- Extracellular vesicles in disease
- Bacterial Genetics and Biotechnology
- Adolescent and Pediatric Healthcare
- Autoimmune and Inflammatory Disorders Research
- bioluminescence and chemiluminescence research
- Bacteriophages and microbial interactions
- Vitamin C and Antioxidants Research
Shenzhen Maternity and Child Healthcare Hospital
2023-2025
Southern Medical University
2024-2025
Obstetrics and Gynecology Hospital of Fudan University
2020-2024
State Key Laboratory of Oncogene and Related Genes
2020-2024
Creative Commons
2023
Shanghai First People's Hospital
2016-2019
Shanghai Jiao Tong University
2015
Hebei Medical University
2010
Second Hospital of Hebei Medical University
2010
Epidemiological evidence indicates that preeclampsia (PE) is associated with comorbidities such as periodontitis (PD). However, the underlying mechanism remains unclear. To enhance our understanding of their co-pathogenesis, this research investigated shared biomarkers and pathological mechanisms. We systematically retrieved transcriptomic datasets from Gene Expression Omnibus database. These encompass a comparative analysis periodontium without PD placenta PE. Differentially Expressed Genes...
Long-chain per- and polyfluoroalkyl substances (PFASs) their short-chain alternatives have been produced used extensively in China. However, it is unclear whether these compounds contribute to the risk of gestational diabetes mellitus (GDM) women residing contaminated areas. The study was performed explore association between PFASs varying chain length developing GDM. A nested case-control conducted a prospective cohort 2,460 pregnant July 1, 2017, January 31, 2019 Shanghai, Twelve interest...
Preeclampsia (PE) is a leading cause of maternal and fetal morbidity mortality. Although increasing lines evidence suggest that both the placenta decidua likely play roles in pathogenesis PE, molecular mechanism PE remains elusive partly because heterogeneity nature maternal-fetal interface. In this study, we perform single-cell RNA-seq on decidual from patients with late-onset (LOPE) women normal pregnancy. Analyses transcriptomes reveal LOPE, there are global development deficiency...
Abstract Background Preeclampsia is a common pregnancy complication characterized by high blood pressure and damage to organs. Abnormal placenta vascular function can lead preeclampsia. Accumulating evidence has suggested potential link between circular RNAs (circRNAs) As endothelial-expressed circRNA, hsa_circ_0002348, may be promising the novel molecular target for However, mechanism of hsa_circ_0002348 in preeclampsia not been elucidated. Materials methods An overlap analysis two circRNA...
BackgroundPreeclampsia is a devastating hypertensive disorder of pregnancy with unknown mechanism. Recent studies have considered abnormal autophagy as new cellular mechanism for this disorder, while little known about how specifically involved and what factors are implicated. Here, we report previously unrecognized preeclampsia-associated autophagic regulator, PKCβ, that in placental angiogenesis.MethodsPKCβ levels were evaluated by quantitative real-time PCR, western blotting,...
Preeclampsia is regarded as an evolution-related disease that has only been observed in humans and our closest relatives, the important factor contributing to its pathogenesis endothelial dysregulation secondary a stressed placenta. Hypoxia-inducible 1 subunit alpha (HIF1α), highly conserved molecule virtually all mammals, crucial regulator of hypoxia adaptation evolution. Persistent high expression HIF1α placenta one pathogenic mechanisms preeclampsia. Therefore, human-specific molecules...
Altered maternal serum lipid metabolism is associated with hypertensive disorders in pregnancy (HDP). However, its range and characteristic among different subgroups of HDPs are unclear. Pregnant women HDP who underwent antenatal care delivered Obstetrics Gynecology Hospital Fudan University during January 2018 to August 2022 were enrolled. The levels total cholesterol (TC), triglycerides (TG), high-density lipoprotein (HDLC), low-density (LDLC), apolipoprotein (Apo)-A, B, E, free fatty...
The toxic shock syndrome toxin-1 (TSST-1), encoded by tst gene, has been proposed to cause staphylococcal (TSS) in a susceptible host, which highlights the need evaluate level of gene expression and molecular genetic characteristics tst-positive isolates. A total 916 S. aureus isolates collected from seven hospitals China were screened for gene. positive characterized spa, SCCmec, PFGE agr typing. Representative strains also subjected MLST qRT-PCR was used quantify major virulence regulator...
Preeclampsia, defined as a hypertensive disorder during pregnancy, is major cause of maternal and fetal mortality. Observational studies have shown that the exposure per- polyfluoroalkyl substances, such perfluorooctane sulfonate (PFOS), emerging significant environmental factor associated with preeclampsia risk. However, epidemiologic evidence correlative in nature, unable to establish causal relationship. Here, we established an animal model PFOS-induced explore molecular mechanism PFOS...
Panton-Valentine leukocidin (PVL, encoded by lukSF-PV genes), a bi-component and pore-forming toxin, is carried different staphylococcal bacteriophages. The prevalence of PVL in Staphylococcus aureus has been reported around the globe. However, data on PVL-encoding phage types, gene variation chromosomal insertion sites for PVL-positive S. are limited, especially China. In order to obtain more complete understanding molecular epidemiology aureus, an integrated modified PCR-based scheme was...
Abstract Background: China's two-child policy has led to a trend of aging in pregnancy which was associated with adverse outcomes. This study aimed identify the clinically cutoff maternal age for obstetric outcomes China. Methods: secondary analysis multicenter retrospective cohort included data childbearing women from 39 hospitals collected urban China during 2011 2012. Logistic regression used assess adjusted odds ratios (aOR) different groups comparison aged 20 24 years. The adjustments...
Importance Antenatal corticosteroid treatment of individuals with singletons at risk for delivery during the late-preterm period has been academically recommended. However, evidence on use antenatal twins is still lacking. Objective To evaluate whether in twin pregnancies was associated a lower newborn morbidity. Design, Setting, and Participants This retrospective cohort study delivered from February 1, 2013, to September 30, 2020, university-affiliated hospital China included 1974 who were...
Abstract Background C ircRNA‐ e ncoded p roteins (CEPs) are emerging as new players in health and disease, function baits for the common partners of their cognate l inear‐spliced RNA (LEPs). However, prevalence across human tissues biological roles remain largely unexplored. The placenta is an ideal model identifying CEPs due to its considerable protein diversity that required sustain fetal development during pregnancy. aim this study was evaluate circRNA translation placenta, potential...
Preeclampsia (PE), characterised by hypertension in pregnancy, is regarded as a placental metabolism-related syndrome affecting 5-8% of pregnancies worldwide. The insufficiency polyunsaturated fatty acids (PUFAs), such docosahexaenoic acid (DHA), causative factor PE pathogenesis. However, its molecular aetiology yet to be comprehensively elucidated.
Aim Our previous proteomic analysis showed that small RNA SprC (one of the pathogenicity island RNAs) Staphylococcus aureus possesses ability to regulate expression multiple bacterial proteins. In this study, our objective was further provide insights into regulatory role in gene transcription and metabolism S. . Methods Gene profiles were obtained from N315 wild-type its sprC deletion mutant strains by RNA-sequencing (RNA-seq), differentially expressed genes (DEGs) screened R language with...
Abstract Introduction Subclinical hypothyroidism (SCH) during pregnancy is reported to have detrimental impact on and child development. However, its treatment indications require further investigation in different thyroid peroxidase antibody (TPOAb) status. Material methods This was a secondary analysis of Chinese prospective cohort real‐world setting. Pregnant women with gestational SCH were enrolled at the first antenatal visit grouped by TPOAb positivity. Child neurodevelopment assessed...