A5100765665- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Birth, Development, and Health
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Gestational Diabetes Research and Management
- Chemical Synthesis and Analysis
- Sulfur-Based Synthesis Techniques
- Health, Environment, Cognitive Aging
- Synthesis and Catalytic Reactions
- Pesticide Exposure and Toxicity
- Air Quality and Health Impacts
- Insect and Pesticide Research
- Pesticide Residue Analysis and Safety
- Asymmetric Synthesis and Catalysis
- Child Nutrition and Water Access
- Cardiac Imaging and Diagnostics
- Click Chemistry and Applications
- Cardiovascular Function and Risk Factors
- Pregnancy and Medication Impact
- Gut microbiota and health
- Chemical Synthesis and Reactions
- Radical Photochemical Reactions
- Breastfeeding Practices and Influences
- Carcinogens and Genotoxicity Assessment
National Health and Family Planning Commission
2019-2024
Shanghai Medical College of Fudan University
2023-2024
Fudan University
2016-2024
Zhongshan Hospital
2024
Huaqiao University
2024
University of Vermont Medical Center
2024
National Center for Infectious Diseases
2024
Institute of Oceanographic Instrumentation
2021-2023
Shandong Academy of Sciences
2021-2023
Qilu University of Technology
2020-2023
Prenatal exposure to heavy metals, pesticides and phenols has been suggested interfere with neurodevelopment, but the neurotoxicity of their mixtures is still unclear. We aimed elucidate associations maternal urinary concentrations selected chemical intelligence quotient (IQ) in children. Maternal pesticide metabolites, were quantified pregnant women who participated Sheyang Mini Birth Cohort Study (SMBCS) from June 2009 January 2010. At age 7 years, child's IQ score was assessed using...
Long-chain per- and polyfluoroalkyl substances (PFASs) their short-chain alternatives have been produced used extensively in China. However, it is unclear whether these compounds contribute to the risk of gestational diabetes mellitus (GDM) women residing contaminated areas. The study was performed explore association between PFASs varying chain length developing GDM. A nested case-control conducted a prospective cohort 2,460 pregnant July 1, 2017, January 31, 2019 Shanghai, Twelve interest...
Prenatal exposure to per- and polyfluoroalkyl substances (PFASs) influences neurodevelopment. Thyroid homeostasis disruption is thought be a possible underlying mechanism. However, current epidemiological evidence remains inconclusive. This study aimed explore the effects of prenatal PFAS on intelligence quotient (IQ) school-aged children assess potential mediating role fetal thyroid function. The included 327 7-year-old from Sheyang Mini Birth Cohort Study (SMBCS). Cord serum samples were...
A one-step reductive ligation mediated disulfide formation of S-nitrosothiols was developed. This reaction involves the S-nitroso group with phosphine-thioesters to form sulfenamide and thiolate intermediates, which then undergo a fast intermolecular stable conjugates. can be used design new biosensors S-nitrosated proteins.
Higher melamine exposure may increase the risk of kidney stone formation and injury in infants, but little is known about potential nephrotoxic effects environmental low-dose its derivative on function adults general population. Our objective was to assess associations between urinary concentrations derivative, cyanuric acid, through analyzing data from National Health Nutrition Examination Survey (NHANES) 2003–2004. Information 298 participants aged ≥20 years utilized. Urinary acid levels...
A bis-ligation reaction of S-nitrosothiols using triaryl substituted phosphine-thioester substrates has been developed. This converts unstable primary to stable disulfide-iminophosphorane products in high yields under mild conditions. It can potentially be applied for the detection S-nitrosation protein systems.
A reductive elimination of S-nitrosocysteines using phosphine substrates has been developed. This reaction converts unstable to dehydroalanine derivatives under very mild conditions. It can potentially be applied for the detection protein S-nitrosation.
Per- and polyfluoroalkyl substances (PFAS) have been suspected as potential environmental obesogens, with several mechanisms being proposed, including the role of metabolomics. However, current epidemiological studies yielded inconclusive findings.
The first "traceless" reductive ligation of S-nitrosothiols using phosphine ester/thioester conjugates is reported. Experiments also show that stable thioimidate compounds could be formed in the reaction between and some phosphine−thioester substrates.
Early-life carbamate exposure during developmental period has been linked with adverse health effects and attracted attention.Three hundred three children at age of seven were included in the current study. Urinary carbofuranphenol concentrations measured using gas chromatography-tandem mass spectrometry. Verbal, performance full-scale intelligence quotients (IQV, IQP, IQFS) assessed Wechsler Intelligence Scale for Children-Chinese Revised. Generalized linear models used to explore...