Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures elucidated on basis spectroscopic methods, single-crystal X-ray diffraction analysis, electronic circular dichroism calculations. biogenetic pathway for 1 2 is proposed. Both showed no significant antibacterial activity or cytotoxicity at 50 μM.

Six new isocoumarins, compounds<bold>1–4</bold>and<bold>14–15</bold>, two benzofurans,<bold>16–17</bold>, along with nine known isocoumarin analogues,<bold>5–13</bold>were obtained from the mangrove endophytic fungus<italic>Talaromyces amestolkiae</italic>YX1.

Two new chlorinated preussomerins, chloropreussomerins A and B (1 2), together with nine known preussomerin analogues, 3–11, were obtained from the endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. Their structures elucidated by a combination of spectroscopic analyses. The absolute configurations 1 2 both determined single-crystal X-ray diffraction using Cu Kα radiation. Chloropreussomerins 2) are first compounds in family, M (3) is reported for time as natural product. Compounds showed...

Sour rot, caused by Geotrichum citri-aurantii, is a major postharvest disease in citrus and results significant economic losses. The genus Beauveria recognized as promising source of biocontrol agents for agricultural applications. Herein, we established targeted strategy integrating genomics metabolomics to accelerate the discovery new cyclopeptides from antagonistic metabolites produced marine-derived fungus felina SYSU-MS7908. As result, isolated characterized seven cyclopeptides,...

Nine polyketides, including two new benzophenone derivatives, peniphenone (1) and methyl (2), along with seven known xanthones (3-9) were obtained from mangrove endophytic fungus Penicillium sp. ZJ-SY₂ isolated the leaves of Sonneratia apetala. Their structures elucidated on basis MS, 1D, 2D NMR data. Compounds 1, 3, 5, 7 showed potent immunosuppressive activity IC50 values ranging 5.9 to 9.3 μg/mL.

Ten new isocoumarins, named peniisocoumarins A–J (1–9 and 11), along with three known analogues (10, 12, 13) were obtained from the fermentation of an endophytic fungus, Penicillium commune QQF-3, which was isolated a fresh fruit mangrove plant Kandelia candel. Their structures elucidated through extensive spectroscopic analysis. The absolute configurations 1–7 determined by single-crystal X-ray diffraction modified Mosher's method, those 8, 9, 11 assigned on basis experimental calculated...

Four new polyketides: nectriacids A-C (1-3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), macrocarpon C (7) were isolated from the culture of endophytic fungus Nectria sp. HN001, which was a fresh branch mangrove plant Sonneratia ovata collected South China Sea. Their structures determined by detailed analysis NMR mass spectroscopic data. The absolute configuration stereogenic carbons for compound 4 further assigned...

Eight new dimeric sorbicillinoids (1-3, 5-9) and 12 monomeric (10-20, 25), along with five known analogues (4 21-24), were isolated from the marine-derived fungus Trichoderma reesei 4670. Their structures elucidated on basis of extensive spectroscopic analyses (1D 2D NMR, HR-ESIMS, ECD) X-ray crystallography. Compound 1, containing a pyrrolidin-2-one moiety, is reported for first time in sorbicillinoid family. Compounds 8 9 are examples bisorbicillinoids possessing benzofuro[2,3- h]chromene...

Isaridin E, a cyclodepsipeptide derived from the marine fungus Beauveria felina (SYSU-MS7908), has been demonstrated to possess multiple biological properties. In this study, we employed both lipopolysaccharide (LPS)-stimulated human umbilical vein endothelial cells (HUVECs) and LPS-induced murine endotoxemia model investigate its anti-inflammatory effects. Our results revealed that isaridin E suppressed expression of pro-inflammatory cytokines adhesion molecules in concentration dependent...

Two new sulfur-containing benzofuran derivatives, eurothiocin A and B (1 2), along with five known compounds, zinniol (3), butyrolactone I (4), aspernolide D (5), vermistatin (6), methoxyvermistatin (7), were isolated from the cultures of Eurotium rubrum SH-823, a fungus obtained Sarcophyton sp. soft coral collected South China Sea. The compounds 2) share methyl thiolester moiety, which is quite rare among natural secondary metabolites. structures these metabolites assigned on basis detailed...

Six new meroterpenoids, which have been named as stachybonoids A–F (<bold>1–3</bold> and <bold>5–7</bold>), three known phenylspirodrimanes (<bold>4</bold>, <bold>8</bold> <bold>9</bold>) were isolated from the crinoid-derived fungus <italic>Stachybotrys chartarum</italic> 952.

Lasiodiplactone A (1), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 established by analysis NMR spectroscopic data and electronic circular dichroism (ECD) spectra. (1) first example lactone that possesses a unique tetracyclic system (12/6/6/5) RAL12 (12-membered β-resorcylic acid lactone) with pyran ring furan ring. possible biogenetic pathway for proposed. Compound showed anti-inflammatory activity inhibiting...

An unusual alkaloid, talaramide A (<bold>1</bold>), was obtained from the mangrove endophytic fungus<italic>Talaromyces</italic>sp. (HZ-YX1).

A new α-pyrone derivative, phomopyrone (1), together with two known compounds (2-3), was isolated from the culture of mangrove endophytic fungus Phomopsis sp. HNY29-2B. Their structures were determined by detailed analysis spectroscopic data. The configuration 1 further confirmed X-ray diffraction. All evaluated for antibacterial and antioxidative activities. Compound 2 exhibited activities minimal inhibition concentration (MIC) values 25 50 μM against Bacillus subtilis Pseudomonas...

Three new depsidones, botryorhodines E–G ( 1 – 3 ), and two isoindolinones, meyeroguillines A B 7 9 along with five known compounds were isolated from an endophytic fungus Meyerozyma guilliermondii , derived the mangrove plant Kandelia obovata. Their structures elucidated by 1D 2D NMR spectroscopy high resolution mass spectrometry (HREIMS). Compounds 6 exhibited strong α-glucosidase inhibitory activity IC 50 values ranging 2.1 to 13.3 μM. Moreover, kinetic studies of 2 showed that both them...

Chemical investigation of the endophytic fungus Aspergillus sp. 16-5B cultured on Czapek's medium led to isolation four new metabolites, aspergifuranone (1), isocoumarin derivatives (±) 2 and 3, (R)-3-demethylpurpurester A (4), together with known purpurester B (5) pestaphthalides (6). Their structures were determined by analysis 1D 2D NMR spectroscopic data. The absolute configuration Compound 1 was comparison experimental calculated electronic circular dichroism (ECD) spectra, that 4...