A5100411737- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Alzheimer's disease research and treatments
- Healthcare and Venom Research
- Fungal Biology and Applications
- Alkaloids: synthesis and pharmacology
- Computational Drug Discovery Methods
- Neuroscience of respiration and sleep
- Bioactive Compounds and Antitumor Agents
- Cancer therapeutics and mechanisms
- Sesquiterpenes and Asteraceae Studies
- Neurological Disease Mechanisms and Treatments
- High Altitude and Hypoxia
- Synthesis and Catalytic Reactions
- Cancer, Hypoxia, and Metabolism
- Ginkgo biloba and Cashew Applications
- Click Chemistry and Applications
- Traditional and Medicinal Uses of Annonaceae
- Tryptophan and brain disorders
- Natural Antidiabetic Agents Studies
- Phytochemical compounds biological activities
- Cholinesterase and Neurodegenerative Diseases
- Traditional Chinese Medicine Analysis
- Chemical synthesis and alkaloids
- Catalytic C–H Functionalization Methods
Zhejiang Chinese Medical University
2024-2025
Sichuan University
2023-2024
Shaanxi University of Chinese Medicine
2024
Xiamen University
2024
West China Second University Hospital of Sichuan University
2023
Guizhou University
2023
Henan University of Traditional Chinese Medicine
2023
University of California, Santa Cruz
2023
Zhejiang Hisun Pharmaceutical (China)
2022
Ningbo University
2019-2022
Eight new dimeric sorbicillinoids (1-3, 5-9) and 12 monomeric (10-20, 25), along with five known analogues (4 21-24), were isolated from the marine-derived fungus Trichoderma reesei 4670. Their structures elucidated on basis of extensive spectroscopic analyses (1D 2D NMR, HR-ESIMS, ECD) X-ray crystallography. Compound 1, containing a pyrrolidin-2-one moiety, is reported for first time in sorbicillinoid family. Compounds 8 9 are examples bisorbicillinoids possessing benzofuro[2,3- h]chromene...
A phytochemical study of the leaves Cyclocarya paliurus led to discovery five naphthalene derivatives (1–5) and two diarylheptanoids (6–7), among which compounds 1 6 are new natural products. The structural elucidation these was achieved through an in-depth examination spectroscopic data, including NMR, MS, IR. Their absolute configurations were established using electronic circular dichroism (ECD) calculation dimolybdenum tetraacetate-induced CD (ICD) experiments. Notably, compound 7...
Six new meroterpenoids, which have been named as stachybonoids A–F (<bold>1–3</bold> and <bold>5–7</bold>), three known phenylspirodrimanes (<bold>4</bold>, <bold>8</bold> <bold>9</bold>) were isolated from the crinoid-derived fungus <italic>Stachybotrys chartarum</italic> 952.
Alzheimer's disease (AD) is characterized by progressive neurodegeneration and impaired cognitive functions. Fascaplysin a β-carboline alkaloid isolated from marine sponge Fascaplysinopsis bergquist in 1988. Previous studies have shown that fascaplysin might act on acetylcholinesterase β-amyloid (Aβ) to produce anti-AD properties. In this study, series of derivatives were synthesized. The cholinesterase inhibition activities, the neuronal protective effects, toxicities these compounds...
Trichobamide A (<bold>1</bold>), a novel pyrrocidine alkaloid with an unprecedented tetrahydro-5<italic>H</italic>-furo[2,3-<italic>b</italic>]pyrrol-5-one moiety, was isolated from the ascidian-derived fungus <italic>Trichobotrys effuse</italic> 4729.
<italic>Origanum vulgare</italic> L. leaf extract showed promising hypoglycemic activity through gluconeogenesis, lipid synthesis and relieving oxidative stress signalling pathway, its potential active phenolic compounds were also identified by HPLC-ESI-Q-TOF-MS method.
Seven polyketides, including two new isochromanes, penisochromanes A and B (1 2), as well five known compounds were obtained from an ascidian-derived fungus Penicillium sp. 4829. Their structures identified by extensive spectroscopic analyses. The of 1 3 further determined the X-ray crystallography. Compounds 2 first example isochromane with three adjacent oxy substituents in natural source. Compound 4 exhibited selective activities against Gram-positive bacteria Staphylococcus aureus...
Five new naphthalenones, two enantiomers (−)-1 and (+)-1 leptothalenone A, (−)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one ((−)-2), (4S, 10R, 4’S)-leptotha-lenone B (5), (4R, 10S, 4’S)-leptothalenone (6), a isocoumarine, 6-hydroxy-5,8-dimethoxy-3-methyl-1H-isochromen-1-one (4), along with known compounds (+)-4,8-dihydroxy-7-(2-hydroxy-ethyl)-6-methoxy-3,4-dihydro-2H-naphthalen-1-one ((+)-2) (+)-10-norparvulenone (3) were isolated from the marine-derived fungus...
Abstract Dispensing granules of Chinese medicine (DGCM) have emerged as a more convenient alternative to traditional decoction (TD) medicine, gaining popularity in recent years. However, the debate surrounding consistency DGCM compared TD remains unresolved. In this study, three batches Baishao and Gancao were obtained from manufacturers A, B, C, 15 crude drugs procured hospital pharmacies for preparation dispensing granule (DGD) Shaoyao‐Gancao (SGD). The HPLC‐UV method was employed...
Two new sesquiterpenes, leptoterpenes A (1) and B (2) were isolated from the fungus Leptosphaerulina Chartarum sp. 3608, derived a crinoid. It was first chemical study on this species. The structures of these compounds elucidated by spectroscopic methods including NMR MS spectrometry. absolute configurations determined basis single-crystal X-ray diffraction electronic circular dichroism data analysis. All tested for their anti-inflammatory activity inhibitory effects Tyrosyl DNA...
Two new monoterpenoid indole alkaloids, gelselegandines F (1) and G (2), were isolated from the aerial parts of Gelsemium elegans. Their structures elucidated by means spectroscopic techniques quantum chemical calculations. The ECD calculations conducted at B3LYP/6-311G(d,p) level NMR carried out using Gauge-Including Atomic Orbitals (GIAO) method. Structurally, two compounds possessed rare, cage-like, skeletons. All total alkaloids extract tested for cytotoxicity against four different...
Spinal astrocyte-mediated neuroinflammation is an important mechanism for the maintenance of chronic inflammatory pain. Previous studies have investigated that Ras-related C3 botulinum toxin substrate 1 (Rac1) closely related to astrocyte activation after central nervous system injury. However, role Rac1 in pain has not been reported. Complete Freund's adjuvant (CFA)-induced model and LPS-stimulated astrocytes were used investigate underlying mechanism. Rac1-interfering adeno-associated...