A5100761506- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Nanocluster Synthesis and Applications
- Metabolism, Diabetes, and Cancer
- Cancer, Hypoxia, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Wound Healing and Treatments
- Gold and Silver Nanoparticles Synthesis and Applications
- Cancer, Lipids, and Metabolism
- Graphene and Nanomaterials Applications
- Magnolia and Illicium research
- Pancreatic function and diabetes
- Pharmacological Effects of Natural Compounds
- Adipose Tissue and Metabolism
- Bone Metabolism and Diseases
- Ginkgo biloba and Cashew Applications
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Estrogen and related hormone effects
- Electrospun Nanofibers in Biomedical Applications
- Peroxisome Proliferator-Activated Receptors
- Virus-based gene therapy research
- Molecular Sensors and Ion Detection
- Cholesterol and Lipid Metabolism
Hubei University
2015-2025
Ministry of Education of the People's Republic of China
2024
Beijing University of Civil Engineering and Architecture
2023
Mudanjiang Medical University
2020
Kunming Medical University
2017
Fujian Academy of Medical Sciences
2016
Fujian Medical University
2009-2016
Fujian Provincial Hospital
2011-2016
Hubei University of Chinese Medicine
2014
Peking Union Medical College Hospital
2009
Abstract Aggregation‐caused fluorescence quenching with insufficient production of reactive oxygen species (ROS) has limited the application photosensitizers (PSs) in fluorescence‐imaging‐guided photodynamic therapy (PDT). Aggregation‐induced emission PSs (AIE‐PSs) exhibit enhanced intensity and a high efficiency ROS generation aggregation state, which provides an opportunity to solve above problems. Herein, series AIE‐PSs are successfully designed synthesized by adjusting D–A through...
Chemodynamic therapy (CDT) has emerged as a promising approach for treating infected diabetic wounds, while reliable imaging technology simultaneous monitoring of ROS and therapeutic processes is still formidable challenge. Herein, smart covalent organic framework (COF) nanoreactors (COF NRs) are constructed by hyaluronic acid (HA) packaged glucose oxidase (GOx) covalently linked Fe-COF wound healing. Upon the breakdown HA protective layer, GOx consumes to produce gluconic hydrogen peroxide (H
Human patatin-like phospholipase domain-containing 3 ( PNPLA 3) is associated with increased liver fat content and injury. Here, we show that nutritional status regulates PNPLA3 gene expression in the mouse liver. Sterol response element binding protein-1 (SREBP-1) activated transcription via sterol regulatory elements (SREs) mapped to promoter region. Chromatin immunoprecipitation electrophoretic mobility shift assays confirmed SREBP-1 proteins bound identified SREs. Furthermore, SREBP-1c...
Schwann cells injury induced by high glucose (HG) contributes to the development of diabetic peripheral neuropathy (DPN). Honokiol has been reported regulate metabolism, however, its effect on DPN and precise molecular mechanisms remain unclear. This study aimed investigate role AMPK/SIRT1/PGC-1α axis in protective effects honokiol DPN. The biochemical assay JC-1 staining results demonstrated that reduced HG-induced oxidative stress ferroptosis as well mitochondrial dysfunction cells....
Abstract There is yet no cure for type 1 diabetes (T1DM) so far. A significant body of evidence has demonstrated that bone marrow-derived mesenchymal stem cells (BMSCs) showed great potential in controlling T1DM. But there exists much difficulty using BMSCs as a clinical therapy. We here test whether new population from human gingiva (GMSCs), which many advantages over BMSCs, can delay or prevent progress GMSCs were adoptively transferred to multiple low-dose streptozotocin (STZ)-induced...
Reactive oxygen species (ROS) have emerged as a promising treatment option for antibacterial and biofilm eradication. However, their therapeutic efficacy is significantly hampered by the unique microenvironments of diabetic wounds. In this study, we designed synthesized porphyrin-based Fe covalent organic frameworks (Fe-COF) through Schiff base condensation reaction. Subsequently, Fe-COF were encapsulated with hyaluronic acid (HA) electrostatic adsorption, resulting in novel formulation...
Chrysanthemum morifolium Ramat. (CM) and Coreopsis tinctoria Nutt. (CT), known as "Juhua" in China, are frequently consumed tea. However, comparative studies on their chemical composition biological activity lacking. This study analyzed the constituents of CM CT aqueous extracts using high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (HPLC-DAD-ESI-QTOF-MS) assessed hypoglycemic antioxidant activities. Both primarily...
Brown and beige adipocytes dissipate energy to generate heat through uncoupled respiration, the hormone norepinephrine plays an important role in stimulating brown fat thermogenesis adipocyte development white adipose depots. Increasing expenditure by promoting function of is a potential approach treat obesity diabetes. Here, we investigated effects macrophage sirtuin 6 (SIRT6 ) on regulation content tissue (BAT) mice. Myeloid SIRT6 deficiency impaired thermogenic BAT, thereby decreasing...
The isoflavone calycosin-7-O-β-d-glucopyranoside (CG) is a principal constituent of Astragalus membranaceus (AR) and has been reported to inhibit osteoclast development in vitro bone loss vivo. aim this study was investigate the osteogenic effects CG its underlying mechanism ST2 cells. results show that exposure cells differentiation medium increases ALP activity, osteocalcin (Ocal) mRNA expression osteoblastic mineralization process. Mechanistically, treatment increased morphogenetic...
Persistent inflammation and bacterial infection are common during wound healing, high blood sugar provides enough nutrients for growth to make wounds more prone ulcers. Herein, glucose oxidase (GOx) is mineralized with calcium phosphate (CaP) circled Cu 2 O/Pt nanozyme form a core-shell structural CaP-GOx-Cu nanoparticles (GOx-CaPCuPt nanoreactor ) by one-step biomimetic mineralization method. The as-prepared biodegradable acidity-responsive GOx-CaPCuPt can be used near-infrared imaging...
Herein, five aggregation-induced emission (AIE) photosensitizers (PSs) with D–π–A structures are smoothly designed and synthesized through donor acceptor engineering.
Astragaloside I (As-I), one of the main active ingredients in Astragalus membranaceus, is believed to have osteogenic properties, but this hypothesis has not been investigated detail. In present work, As-I-induced effects and its underlying mechanism were studied MC3T3-E1 cells. The results indicated that cellular levels ALP extracellular matrix calcium increased a dose-dependent manner by As-I. To clarify mechanisms involved process, effect As-I on key osteogenic-related genes was...