A5102729371- Tuberous Sclerosis Complex Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- Lung Cancer Treatments and Mutations
- SARS-CoV-2 and COVID-19 Research
- Acute Myeloid Leukemia Research
- Neonatal Respiratory Health Research
- Pulmonary Hypertension Research and Treatments
- Cancer-related molecular mechanisms research
- Lymphoma Diagnosis and Treatment
- Long-Term Effects of COVID-19
- Protein Degradation and Inhibitors
- Climate Change and Health Impacts
- HIV Research and Treatment
- Asthma and respiratory diseases
- Corporate Governance and Law
- Systemic Sclerosis and Related Diseases
- Lung Cancer Research Studies
- Air Quality and Health Impacts
- Cancer Genomics and Diagnostics
- Circular RNAs in diseases
- Ubiquitin and proteasome pathways
- Vascular Tumors and Angiosarcomas
- RNA modifications and cancer
Shanxi Academy of Medical Sciences
2019-2025
Shanxi Medical University
2024-2025
Shanxi Provincial Cancer Hospital
2018-2025
Zhejiang University
2010-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Stomatology Hospital
2021-2025
Peking Union Medical College Hospital
2012-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2013-2024
Abstract Parkin is a RING-between-RING E3 ligase that functions in the covalent attachment of ubiquitin to specific substrates, and mutations are linked Parkinson’s disease, cancer mycobacterial infection. The family ligases suggested function with canonical RING domain catalytic cysteine residue usually restricted HECT ligases, thus termed ‘RING/HECT hybrid’ enzymes. Here we present 1.58 Å structure Parkin-R0RBR, revealing fold architecture for four domains, several unpredicted interfaces....
Abstract Background COVID-19 is a viral respiratory disease caused by the severe acute syndrome-Coronavirus type 2 (SARS-CoV-2). Patients with this may be more prone to venous or arterial thrombosis because of activation many factors involved in it, including inflammation, platelet and endothelial dysfunction. Interferon gamma inducible protein-10 (IP-10), monocyte chemoattractant protein-1 (MCP-1) macrophage inflammatory protein 1-alpha (MIP1α) are cytokines related thrombosis. Therefore,...
Immune checkpoint blockage (ICB) therapy has shown minimal effectiveness in anaplastic lymphoma kinase (ALK)-positive nonsmall cell lung cancer (NSCLC) regardless of Programmed death-ligand 1 expression. ALK fusion accompanied by mismatch repair deficiency or microsatellite instability-high (MMRd/MSI-H) and high tumor mutation burden (TMB-H) are extremely rare NSCLC, the efficacy inhibitors ICB-based therapies is unclear. Here, we report case a 60-year-old female patient with metastatic...
Abstract Background Exposure to air pollution is associated with chronic obstructive pulmonary disease (COPD). However, findings on the effects of lung function and systemic inflammation in Chinese COPD patients are inconsistent scarce. This study aims evaluate ambient parameters serum cytokine levels a cohort Beijing, China. Methods We enrolled participants rolling basis from December 2015 September 2017 Follow-ups were performed every 3 months for each participant. Serum 20 cytokines...
Abstract Background We investigated the feasibility of two biomarkers endothelial damage (Syndecan-1 and thrombomodulin) in coronavirus disease 2019 (COVID-19), their association with inflammation, coagulopathy, mortality. Methods The records 49 COVID-19 patients who were admitted to an intensive care unit (ICU) Wuhan, China between February April 2020 examined. Demographic, clinical, laboratory data, outcomes compared survivors non-survivors patients, high low serum Syndecan-1 levels....
Evidence between air pollution and COPD admissions is inconsistent limited in China. In this study, we aimed to explore the effects of pollutants on Beijing, China.Daily hospital admission visits derived from tertiary secondary hospitals Beijing were retrieved January 2013 February 2017. Air pollutant levels meteorological data over same periods also achieved. Generalized additive model was applied estimate percentage changes with 95% CIs daily corresponding 10 µg/m3 increases [1 mg/m3...
BackgroundLymphangioleiomyomatosis is a progressive diffuse cystic lung disease with approximately 85% survival at 10 years. The determinants of progression and mortality after the introduction sirolimus therapy vascular endothelial growth factor D (VEGF-D) as biomarker have not been well defined.Research QuestionWhich factors, including VEGF-D therapy, influence prognosis in patients lymphangioleiomyomatosis?Study Design MethodsThe dataset included 282 574 patients, respectively, from...
To identify key technologies within non-bioartificial liver (NBAL, an extracorporeal support system that temporarily replaces some of the liver's functions) nursing to offer guidance for clinical practice. In context NBAL nursing, are crucial successful implementation artificial treatment, ensuring patient safety, and enhancing quality. A review both domestic foreign literature revealed studies on technology lacking have not been clearly identified. Using empirical research methods collect...
The aim of this study was to investigate lymphocyte subsets, especially natural killer (NK) cells, in patients with systemic sclerosis (SSc) and evaluate the diagnostic value NK cells secondary pulmonary arterial hypertension (PAH). A total 115 SSc 100 age- sex-matched health controls (HCs) were enrolled study. Flow cytometry employed quantify while association between disease activity as well PAH investigated further elucidate its potential. absolute count (CD3-CD56+) significantly...
This study aimed to investigate the current status of oral healthy literacy (OHL) among elderly in Hangzhou and analyze its influencing factors. A convenience sampling method was used select 222 people living from August 2022 January 2023. The General Information Questionnaire, Simplified Version Oral Health Literacy Scale (HeLD-14), Social Support Rating (SSRS), Self-Efficacy (GSES) were employed factors OHL elderly. total score 37 (31, 41) points, results regression analysis showed that...
To investigate alterations in blood lipid profiles and T cell subsets among systemic sclerosis (SSc) patients, to assess their potential utility predicting cardiovascular disease (CVD) risk. 105 SSc patients 80 age- sex-matched healthy controls (HCs) were enrolled. Flow cytometry was employed quantify subsets. Multivariate logistic regression analysis investigated the association between profile, subsets, occurrence, CVD Additionally, a prediction model developed predictive value of In...
Recent published studies suggest that increasing levels of ceramides enhance the chemo‐sensitivity curcumin. Using in vitro approaches, we analyzed impact sphingosine kinase‐1 ( S ph K ‐1) inhibition on ceramide production, and evaluated SphK1 inhibitor II SKI ‐ ) as a potential curcumin chemo‐sensitizer ovarian cancer cells. We found 1 is overexpressed patients' tumor tissues cultured cell lines. Inhibition by or RNA interference i) knockdown dramatically enhanced curcumin‐induced apoptosis...
Sirolimus has been confirmed to be effective for lymphangioleiomyomatosis (LAM), a rare multisystem neoplastic disease in women. The long-term effects of sirolimus treatment LAM, however, are largely unknown. We aimed analyze the efficacy and safety therapy LAM with 4-year follow-up. In total, 142 sporadic patients who took 1–4 years were retrospectively enrolled this analysis. variables used analysis included pulmonary function tests, arterial blood gas analysis, 6-min walking distance...
Abstract Chronic lymphocytic leukaemia (CLL) is the most prevalent and remains incurable. Mesenchymal stem cells (MSCs) can promote tumour progression by differentiating into cancer-associated fibroblasts (CAFs). However, mechanisms which induce transition of MSCs to CAFs are still largely undefined. Exosomes regulate recipient cellular function mediating intracellular communication. This study aimed investigate whether CLL bone marrow-derived (BM-MSCs) via exosomal miR-146a delivery. The...
Developing multifunctional metal-organic frameworks (MOFs) is a new research trend. MOFs have shown remarkable performances in both proton conduction and fluorescence sensing, but the integrating two are scarce. Herein, Co-MOF, [Co6(oba)4(Hatz)(atz)(H2O)2(μ3-OH)2(μ2-OH)]·H2O (1, H2oba = 4,4-oxybis(benzoic acid), Hatz 5-amino-1H tetrazole), has been assembled by Co2+ ions with ligands, providing unique example of sensing performances. The framework 1 displays pillar-layer structure built oba...
Members of the Cide [cell death-inducing DFFA (DNA fragmentation factor-α)-like effector] gene family have been reported to be associated with lipid metabolism. In present study, we show that Cidea mRNA levels are markedly reduced by fasting and restored upon refeeding in mouse livers. To elucidate molecular mechanism, promoter region was analysed a putative SRE (sterol-regulatory element) identified. Studies using luciferase reporter constructs together electrophoretic mobility-shift assays...
Background The lowering of body temperature is a common, almost reflexive step in the daily care septic shock patient. However, effect different magnitudes fever control on outcome refractory patients with very poor controversial and has yet to be explored. Methods This prospective trial examined sixty-five core higher than 38.5°C. Patients were randomly assigned group achieving “low temperature” range (LT group: 36.0-37.5 °C) or “high (HT 37.5-38.3 by physical methods including water-flow...