A5101400634- Thyroid Cancer Diagnosis and Treatment
- Diabetes Treatment and Management
- Pancreatic function and diabetes
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Magnesium in Health and Disease
- Thyroid Disorders and Treatments
- Liver Disease Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Ion Transport and Channel Regulation
- Vitamin D Research Studies
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Thyroid and Parathyroid Surgery
- Eating Disorders and Behaviors
- Head and Neck Anomalies
- Biomedical Research and Pathophysiology
- Diet, Metabolism, and Disease
- Potassium and Related Disorders
- Lipid metabolism and disorders
- Liver Disease and Transplantation
- S100 Proteins and Annexins
- Retinal Imaging and Analysis
- Biochemical Analysis and Sensing Techniques
- Medicinal Plant Pharmacodynamics Research
Tianjin Huanhu Hospital
2025
Qingdao University
2014-2024
Affiliated Hospital of Qingdao University
2014-2024
Chinese Academy of Agricultural Sciences
2022
Institute of Animal Sciences
2022
Shanghai Medical College of Fudan University
2021
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both pancreas liver glucokinase, postprandial in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, efficacy safety of dorzagliatin as an add-on to metformin were assessed T2D who had inadequate glycemic control using alone. Eligible (n = 767)...
Aldehydes are primary volatile organic compounds (VOCs) in local Chinese chicken meat and contribute green grass, fatty, citrus, bitter almond aromas to meat. To understand the genetic basis of these aldehyde VOC aromas, we used approximately 500 Jingxing Yellow (JXY) chickens conduct genome-wide association studies (GWAS) on flavor traits with data single nucleotide polymorphisms (SNPs) insertions deletions (INDELs). In total, 501 variants (253 SNPs 248 INDELs) were found be suggestively...
Background Sepsis-associated encephalopathy (SAE) is a common and severe complication of sepsis, significantly contributing to morbidity mortality. The impact specific blood-borne pathogens on SAE risk prognosis remains unclear. This study investigates the microbiological clinical factors associated with bloodstream infection-induced SAE. Methods We analyzed data from MIMIC-IV database, including 16,141 sepsis patients who met inclusion criteria. Patients were divided into non-SAE groups for...
The association between autoimmune thyroid disease and cancer remains unclear. We performed a matched case-control study to assess the Hashimoto's thyroiditis papillary microcarcinoma (PTMC). A total of 927 PTMC cases age- gender- controls selected from same population were recruited. Odds ratio (OR) with 95% confidence interval (95% CI) was used strength PTMC. Conditional logistic regression analysis carried out, stratified analyses by age, gender types antibodies also performed....
Background Lymph node metastasis is the major cause of increased recurrence and death in patients with papillary thyroid carcinoma (PTC). We evaluate clinicopathologic factors affecting excellent response (ER) PTC lymph following operation 131 I ablation therapy. Methods A total 423 who underwent thyroidectomy postoperative therapy were enrolled. The relationship between clinicopathological ER achievement was analyzed. Results Multivariate analysis showed that foci diameter (≤1 cm),...
Purpose: Radioiodine (131I) thyroid remnant ablation is an important treatment of differentiated carcinoma (DTC) and various factors affecting its efficacy have been reported but not well defined. The aim our study was to evaluate the 131I after total or near-total thyroidectomy in a relative large DTC cohort. Methods: 261 patients with negative thyroglobulin antibody received 100-200 mCi for between January 2012 October 2015 hospital. therapy were retrospectively investigated. Results:...
To explore the influencing factors and cumulative risk of lymph node metastasis (LNM) in papillary thyroid microcarcinoma (PTMC) patients.607 patients confirmed PTMC pathologically after thyroidectomy were enrolled this retrospective study. The rate LNM was calculated. Different clinicopathological characteristics compared with without different subgroups LNM, respectively. Correlation between analyzed according to calculated.(1) There 228 cases (37.56%) combined LNM. Compared non-lymph...
Abstract Background Gitelman syndrome is a rare salt-losing renal tubular disorder associated with mutation of SLC12A3 gene, which encodes the Na-Cl co-transporter (NCCT). characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and renin-angiotensin-aldosterone system (RAAS) activation. Different variants may lead to phenotypic variability severity. Methods In this study, we reported clinical features genetic analysis Chinese pedigree diagnosed syndrome. Results The...
Abstract Aims Type 2 diabetes mellitus (T2DM) commonly combines with dyslipidemia, and both are known as the risk factors of cardiovascular events aggravate arteriosclerosis progression. In this study, we investigated relationship between follicle‐stimulating hormone (FSH) lipid profiles in male T2DM patients. Materials Methods We collected clinical data patients Chinese Han population hospitalised from January 2018 to June 2020. A total 963 a mean age 58.89 ± 12.25 years old were enroled...
Objective: To investigate the effect of liraglutide on glucagon release in obese type 2 diabetes (T2DM). Methods: A multi-center, prospective, and self-comparison study was conducted four hospitals Qingdao. Twenty-four patients with T2DM were selected treated for 12 weeks. Glucagon levels before after treatment detected 30 min, 60 min 120 meals. Results: After weeks treatment, overall level decreased, which differences at [(220±79) ng/L vs. (203±77) ng/L, P<0.05] [(248±119) (203±82)ng/L,...
Abstract Improvement of glucose and insulin sensitivity remains an unmet medical need in diabetes management, which the underlying cause type 2 diabetes(T2D) was not well addressed by current treatment. We report findings a randomized, double-blind, placebo-controlled, phase 3 clinical trial (NCT03173391) to evaluate efficacy safety dorzagliatin, dual-acting glucokinase (GK) allosteric modulator, enhances GK activity T2D patients dependent manner, has demonstrated its effects blood control...
Objective To investigate the distribution of T helper cell 1 (Th1), Th2 and Th17 in peripheral blood patients with carotid atherosclerotic ischemic stroke. Methods There were a total 180 stroke 60 normal controls enrolled this study. According to degree artery stenosis, divided into 3 subgroups: mild stenosis group (N = 60), moderate 60) severe 60). Flow cytometry (FCM) was used test proportion Th1, cells blood. Results Compared control group, Th1 [(5.76 ± 1.81)% vs (3.54 0.29)%, P 0.000]...