A5100764823- Ion Transport and Channel Regulation
- Peroxisome Proliferator-Activated Receptors
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Ion channel regulation and function
- Adipose Tissue and Metabolism
- Metabolism and Genetic Disorders
- Cancer-related molecular mechanisms research
- Gout, Hyperuricemia, Uric Acid
- Potassium and Related Disorders
- Sarcoidosis and Beryllium Toxicity Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Venous Thromboembolism Diagnosis and Management
- Liver Disease Diagnosis and Treatment
- Adrenal Hormones and Disorders
- Folate and B Vitamins Research
- Sulfur Compounds in Biology
- Renal and related cancers
- Electrolyte and hormonal disorders
- Genetic Syndromes and Imprinting
- Genetic and Kidney Cyst Diseases
- Hormonal Regulation and Hypertension
- Head and Neck Anomalies
- Thyroid Disorders and Treatments
Qingdao University
2019-2025
Affiliated Hospital of Qingdao University
2019-2025
Disulfidptosis is independent of apoptosis, ferroptosis, and cuproptosis associated with cancer progression, treatment response, prognosis. However, the predictive potential disulfidptosis-associated lncRNAs in colon adenocarcinoma (COAD) their features tumor immune microenvironment (TIME) require further elucidation.RNA transcriptome, clinical information, mutation data COAD samples were obtained from TCGA database. The risk model was first constructed by co-expression analysis...
Obesity affects 53% of gout patients, while its effect on urate-lowering therapy (ULT) is unclear. This study aimed to compare the response febuxostat among different body mass index (BMI) catalogs male patients. A prospective recruited 633 men with gout, classified by BMI into normal-weight, overweight, and obese groups. Baseline age, disease duration, serum urate (SU) levels were matched simultaneously. All participants received for 12 weeks, increasing dosage from 20 40 mg daily. We...
Background Lymph node metastasis is the major cause of increased recurrence and death in patients with papillary thyroid carcinoma (PTC). We evaluate clinicopathologic factors affecting excellent response (ER) PTC lymph following operation 131 I ablation therapy. Methods A total 423 who underwent thyroidectomy postoperative therapy were enrolled. The relationship between clinicopathological ER achievement was analyzed. Results Multivariate analysis showed that foci diameter (≤1 cm),...
Background. X-linked adrenoleukodystrophy (ALD) is an inherited peroxisomal metabolism disorder, resulting from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 (ABCD1) gene. The dysfunction ALD protein, a transporter, results in excessive saturated very long-chain fatty acids (VLCFAs) accumulation organs including brain, spine, and adrenal cortex. X-ALD characterized as childhood, adolescent, adult cerebral ALD, adrenomyeloneuropathy (AMN), insufficiency,...
Abstract Background Gitelman syndrome (GS) is a type of salt‐losing tubular disease, most which caused by SLC12A3 gene variants, and missense variants account for the majority. Recently, phenomenon exon skipping, in disrupt normal pre‐mRNA splicing, has been related to variety diseases. Therefore, we hypothesize that certain proportion can result disease via interfering with splicing process. Methods We analyzed 342 previously presumed using bioinformatics programs identified candidate may...
Activating transcription factor 6 (ATF6) is an endoplasmic reticulum stress responsive gene. We previously reported that conditional knockout of hepatic ATF6 exacerbated liver metabolic damage by repressing autophagy through mTOR pathway. However, the mechanism which influence metabolism has not been well established. Hydrogen sulfide (H2S) a gaseous signaling molecule plays important role in regulating inflammation, and suppress nonalcoholic fatty mice. Based on previous study, we assumed...
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide. Extensive research currently directed at identifying novel targets for its diagnosis and treatment.
Abstract Background Gitelman syndrome is a rare salt-losing renal tubular disorder associated with mutation of SLC12A3 gene, which encodes the Na-Cl co-transporter (NCCT). characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, and renin-angiotensin-aldosterone system (RAAS) activation. Different variants may lead to phenotypic variability severity. Methods In this study, we reported clinical features genetic analysis Chinese pedigree diagnosed syndrome. Results The...
Hashimoto's thyroiditis (HT) is an autoimmune disease that can cause the dysfunction of glands. Moreover, under-recognized several types tubular such as renal acidosis (RTA), Gitelman's syndrome (GS), and Bartter's (BS). However, potential mechanism acquired BS RTA associated with diseases remains unclear. A 55-year-old female patient presented numbness in both lower extremities for 6 months. She had a 2-year history HT. Laboratory findings showed hypokalemia, metabolic alkalosis, elevated...
Abstract Background: Disulfidptosis is independent of apoptosis, ferroptosis, and cuproptosis associated with cancer progression, treatment response, prognosis. However, the predictive potential disulfidptosis-associated lncRNAs in colon adenocarcinoma (COAD) their features tumor immune microenvironment (TIME) require further elucidation. Methods: RNA transcriptome, clinical information, mutation data COAD samples were obtained from TCGA database. The risk model was first constructed by...
Autosomal Recessive Polycystic Kidney Disease (ARPKD) is a rare hereditary disorder caused by variants in PKHD1. Currently, aberrant splicing has been reported to play important roles genetic disease. Our goal analyze intronic PKHD1 at the mRNA level.
Abstract Background: X-linked adrenoleukodysrophy (ALD) is an inherited peroxisomal metabolism disorder, results from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 ( ABCD1 ) gene. The dysfunction ALD protein, a transporter, in excessive saturated very long chain fatty acids (VLCFAs) accumulation organs including brain, spine and adrenal cortex. X-ALD characterized as childhood, adolescent, adult cerebral ALD, adrenomyeloneuropathy (AMN), insufficiency,...
Lofgren’s syndrome is a variant of acute-onset sarcoidosis, characterized as Hilar Lymphadenopathy (HL), Erythema Nodosum (EN) and bilateral arthritis or arthralgia, with elevated serum Angiotensin Converting Enzyme (ACE) calcium level. It relatively common in Caucasians, but rarely reported Asian countries. We 72-year old Chinese female HL, acute onset EN, multiple achieved remission prednisolone treatment. summarized cases European Asia countries, investigated the characteristics etiology,...
Objective To identify the clinical manifestations, imaging findings, and genetic mutation characteristics in a rare case of adrenoleukodystrophy(ALD)with adrenocortical dysfunction(Addison′s disease)as first manifestation. Methods The data proband his family members were comprehensively collected, ABCDl gene sequencing was meticulously performed for mother using high-throughput method. Results The patient presented with systematical skin pigmentation accompanied by fatigue early...
Abstract Background Gitelman's syndrome (GS) is a rare salt-losing renal tubular disorder associated with SLC12A3 gene mutations, which encodes the Na-Cl co-transporter (NCCT). GS characterized by hypokalaemic metabolic alkalosis, hypomagnesemia, hypocalciuria and elevated renin-angiotensin-aldosterone (RAA) level. The variability of phenotypes likely to be variety mutations. Methods In this study, we reported clinical features genetic analysis family pedigree. Results We identified novel...
Abstract BackgroundX-linked adrenoleukodysrophy (ALD) is an inherited peroxisomal metabolism disorder, results from the loss-of-function mutation of ATP-binding cassette protein subfamily D1 ( ABCD1 ) gene. The dysfunction ALD protein, a transporter, in excessive saturated very long chain fatty acids (VLCFAs) accumulation organs including brain, spine and adrenal cortex. X-ALD characterized as childhood, adolescent, adult cerebral ALD, adrenomyeloneuropathy (AMN), insufficiency, asymptomatic...