A5101834763- Extracellular vesicles in disease
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- RNA Interference and Gene Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Cancer-related gene regulation
- RNA modifications and cancer
- Gastrointestinal Tumor Research and Treatment
- Lung Cancer Treatments and Mutations
- Cancer, Lipids, and Metabolism
- Esophageal Cancer Research and Treatment
- Diabetes Treatment and Management
- Liver physiology and pathology
- Autophagy in Disease and Therapy
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- MXene and MAX Phase Materials
- Hepatitis B Virus Studies
- Colorectal and Anal Carcinomas
- Thermography and Photoacoustic Techniques
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
Tianjin Medical University Cancer Institute and Hospital
2017-2024
National Clinical Research
2024
Anhui Medical University
2023
Baotou Central Hospital
2021-2022
Tianjin Medical University
2014-2020
Capital Normal University
2012-2019
Peking University
1994-2016
Peking University Cancer Hospital
1994-2016
Academy of Medical Sciences
2013
Chinese Academy of Medical Sciences & Peking Union Medical College
2013
Malignant tumors, including colorectal cancer (CRC), usually rely on ATP generation through aerobic glycolysis for both rapid growth and chemotherapy resistance. The M2 isoform of pyruvate kinase (PKM2) has a key role in catalyzing glycolysis, PKM2 expression varies even within single tumor. In this study, we confirmed that is heterogeneous CRC cells, namely high oxaliplatin-resistant cells but relatively low sensitive found chemoresistant had enhanced production. addition, report...
Hepatocellular carcinoma (HCC), the major form of liver cancer, has shown increasing incidence and poor prognosis. Adipose tissue is known to function in energy storage metabolism regulation by secretion adipokines. Circular RNAs (circRNAs), a novel type noncoding RNA, have recently been recognized as key factors tumor development, but role exosome circRNAs derived from adipose tissues not defined yet. Here, adipose-secreted were found regulate deubiquitination HCC, thus facilitating cell...
Chemoresistance is one of the causes adverse effects in gastric cancer, including a poor response to cisplatin (DDP). Exosomes loaded with microRNA (miRNA), mRNA, and other non-coding RNAs could regulate drug resistance. Exo-anti-214 was extracted verified. A Cell Counting Kit-8 (CCK-8) cell viability assay, flow cytometry, transwell immunofluorescence assays were performed determine whether exo-anti-214 sensitize cells DDP vitro. combination intravenously injected intraperitoneal utilized...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy is retracting this article. After investigating concerns image duplication raised by a reader, evidence for in identical or altered fashion Figures 4A, 4G, and S1C was identified. reuse (and part, misrepresentation) data without appropriate attribution represents severe abuse scientific publishing system....
Hypoxia is one of the important properties solid tumor. However, oxygen supply within tumors generally heterogeneous according to distance from nearest blood vessel. The discrepancy metastatic potential exists between hypoxic cancer cells and relatively normoxic cells. But molecular mechanism remains poorly understood.
Abstract Obesity is closely related to a poor prognosis in patients with advanced colorectal cancer (CRC), but the mechanisms remain unclear. Ferroptosis form of nonapoptotic cell death characterized by lipid reactive oxygen species (ROS) accumulation and iron dependency associated chemoresistance tumors. Here, it shown that adipose‐derived exosomes reduce ferroptosis susceptibility CRC, thus promoting oxaliplatin. It found microsomal triglyceride transfer protein (MTTP) expression increased...
Oxaliplatin resistance is a challenge in the treatment of colorectal cancer (CRC) patients. Regulatory T cells (Tregs) are well known for their immunosuppressive roles, and targeting Tregs an effective way to improve chemosensitivity. Exosome-delivered microRNA (miRNA) might be used as potential biomarker predicting However, relationship between exosomal miRNAs remains largely unknown. TaqMan low-density array was performed screen differentially expressed serum from pooled patients who had...
Exosomes derived from cells have been found to mediate signal transduction between and act as efficient carriers deliver drugs small RNA . Hepatocyte growth factor ( HGF ) is known promote the of both cancer vascular cells, ‐ cMET pathway a potential clinical target. Here, we characterized inhibitory effect si on tumor angiogenesis in gastric cancer. In addition, showed that packed exosomes can be transported into where it dramatically downregulates expression. A cell co‐culture model was...
The malignant biological behavior of gastric cancer(GC) is not only determined by cancer cells alone, but also closely regulated the microenvironment. Fibroblasts represent a large proportion components in tumor microenvironment, and they promote development disease. Currently, accumulating evidence suggests that exosomes can function as intercellular transport systems to relay their contents, especially microRNAs(miRNAs).First, we detected highly-expressed level miR-27a isolated from...
Drug resistance often occurs in the treatment of gastric cancer, which is main cause poor prognosis chemotherapy. c-Met overexpressed a variety tumors including leads to therefore regarded as key target for cancer. This study aims determine whether exosomes with si-c-Met could inhibit cisplatin cancer (GC).The protein expression levels tumor tissues and normal patients were evaluated by Western blot (WB) immunohistochemistry (IHC), HEK293T cells transfected si-c-Met, isolated, then...
Abstract Cancer stem cells (CSCs) are an important cause of tumor recurrence and drug resistance. As a new type cell death that relies on iron ions is strictly regulated by intracellular extracellular signals, the role ferroptosis in deserves extensive attention. Mass spectrum was applied to screen for ferroptosis-related proteins gastric cancer (GC). Sphere-formation assay used estimate stemness (GCSCs). Exosomal lnc-ENDOG-1:1 (lncFERO) isolated ultracentrifugation. Ferroptosis induced...
Exosomes, membranous nanovesicles, naturally carry proteins, mRNAs, and microRNAs (miRNAs) play important roles in tumor pathogenesis. Here we showed that gastric cancer (GC) cell-derived exosomes can function as vehicles to deliver miR-155 promote angiogenesis GC. In this study, first detected the expression of c-MYB was negatively correlated GC a direct target miR-155. We next characterized promotional effect exosome-delivered on growth found could inhibit but increase vascular endothelial...
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both pancreas liver glucokinase, postprandial in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, efficacy safety of dorzagliatin as an add-on to metformin were assessed T2D who had inadequate glycemic control using alone. Eligible (n = 767)...
Abstract Background: The risk factors for esophageal squamous cell carcinoma (ESCC) in the high-incidence areas of China remain unclear. Methods: A total 300 patients with ESCC and 900 controls matched age sex were enrolled Anyang (China), a high-risk area China. In tumor tissue cases biopsies controls, presence human papillomavirus (HPV) DNA was assessed by an SPF1/GP6+-mediated PCR followed sequencing. serum antibody against HPV-16 E7 oncoprotein use ELISA. ORs 95% confidence intervals...
This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). retracted at the request of editors. Molecular Therapy - Oncolytics is retracting this article. After investigating concerns image duplication raised by a reader, evidence for in identical or altered fashion Figures 1A, 1E, 3A, 3C, 4C, and 4G was identified. reuse (and part, misrepresentation) data without appropriate attribution represents severe abuse...
Abstract Homeobox genes are known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis. Here, we investigated whether inhibition HOXA13, a member homeobox genes, was sufficient affect proliferation esophageal cancer cells in vitro vivo, studied association HOXA13 expression survival patients with squamous cell carcinoma (ESCC). permanently knocked down using an RNA interference technique, strain stable knockdown protein established. Colony formation...
HSP90 inhibition might be a promising strategy to overcome the radioresistance of some cancers. In current study, we further explored mechanisms in regulating radiosensitivity cervical cancer cells. Bioinformatic analysis was performed based on data from TCGA-CESC. Cellular and molecular studies were conducted using CaSki SiHa derived radioresistant (RR) subclones. Through proteomics screen, identified chaperones (both HSP90α HSP90β) as CD147-binding partners supporting its stabilization....
Abnormal expression of HGF is found in various cancers and correlates with tumor proliferation, metastasis angiogenesis. However, the regulatory mechanism HGF-VEGF axis remains unclear.The characteristic human gastric cancer tissues was shown by an immunohistochemistry assay, levels target protein were detected Western blot. The relative miR-26a/b mRNA examined qRT-PCR. We used bioinformatics tools to search for miRNAs that can potentially HGF. A luciferase assay confirm direct targeting....
The polymorphisms of the tumor suppressor gene p53 have been extensively investigated in numerous malignant tumors, particularly carcinomas associated with human papillomavirus (HPV) infection. However, results remain controversial. To address a potential correlation between genotypes and risk esophageal squamous cell carcinoma (ESCC), we codon 72 polymorphism 435 patients ESCC 550 cancer-free subjects from same geographical region. Arg/Arg genotype was significantly increased cases compared...
Radiation-induced heart disease (RIHD) progresses over time and may manifest decades after the initial radiation exposure, which is associated with significant morbidity mortality. The clinical benefit of radiotherapy always counterbalanced by an increased risk cardiovascular events in survivors. There urgent need to explore effect underlying mechanism radiation-induced injury. Mitochondrial damage widely occurs irradiation-induced injury, mitochondrial dysfunction contributes necroptosis...
Oncolytic adenoviruses (OAds) are alternative immune therapeutic strategies for tumors. However, liver uptake and antibody neutralization two major barriers systemic delivery during the treatment of tumor metastasis. Mesenchymal stem cells (MSCs) have emerged as potential vehicles to improve delivery. In this study, we loaded umbilical-cord-derived MSCs (UC-MSCs) with OAds expressing decorin (rAd.DCN) or without foreign genes (rAd.Null) treat breast cancer lung vivo, rAd.Null, MSCs.Null,...
To determine prevalence of genital human papillomavirus (HPV) infection among men in rural China, we analyzed swab specimens. Among 2,236 male residents Henan Province, HPV was 17.5%. The most common oncogenic and nononcogenic types were HPV-16 HPV-3, respectively. Infection associated with younger age multiple sex partners.