A5100341673- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer Research and Treatments
- Head and Neck Cancer Studies
- Wnt/β-catenin signaling in development and cancer
- Cytokine Signaling Pathways and Interactions
- Epigenetics and DNA Methylation
- interferon and immune responses
- Cervical Cancer and HPV Research
- RNA Research and Splicing
- Intraperitoneal and Appendiceal Malignancies
- Appendicitis Diagnosis and Management
- Educational Reforms and Innovations
- Helicobacter pylori-related gastroenterology studies
- Medical Research and Treatments
- Cancer Mechanisms and Therapy
- Cancer Immunotherapy and Biomarkers
- Psychology of Development and Education
- Cancer-related gene regulation
- Gastric Cancer Management and Outcomes
- Cancer, Hypoxia, and Metabolism
- Innovations in Medical Education
- Developmental Biology and Gene Regulation
- Advances in Oncology and Radiotherapy
Friedrich Schiller University Jena
2020
Peking University
2005-2019
Peking University Cancer Hospital
2009-2019
Tongji University
2008
Stomatology Hospital
2008
National Natural Science Foundation of China
2008
Guangzhou Medical University
2008
Some driver gene mutations, including epidermal growth factor receptor ( EGFR ), have been reported to be involved in expression regulation of the immunosuppressive checkpoint protein programmed cell death ligand 1 PD ‐L1), but underlying mechanism remains obscure. We investigated potential role and precise mutants ‐L1 non‐small‐cell lung cancer NSCLC ) cells. Examination pivotal signaling effectors 8 lines indicated apparent associations between overexpression phosphorylation AKT ERK ,...
Abstract Homeobox genes are known to be classic examples of the intimate relationship between embryogenesis and tumorigenesis. Here, we investigated whether inhibition HOXA13, a member homeobox genes, was sufficient affect proliferation esophageal cancer cells in vitro vivo, studied association HOXA13 expression survival patients with squamous cell carcinoma (ESCC). permanently knocked down using an RNA interference technique, strain stable knockdown protein established. Colony formation...
Heterogeneous nuclear ribonucleoparticule A1/A2 (hnRNP A1/A2) and splicing factor 2/alternative (SF2/ASF) are pivotal for precursor messenger RNA (pre-mRNA) splicing. Interferon regulatory factor-3 (IRF-3) plays critical roles in host defense against viral microbial infection. Truncated IRF-3 proteins resulting from alternative have been identified characterized as functional antagonists to full-length IRF-3. In this study, we examined the molecular mechanism regulation of pre-mRNA first...
e20049 Background: PD-L1 (programmed death ligand 1) is expressed in various kinds of human tumors including non-small cell lung cancer (NSCLC) and critical importance for the immune escape tumor cells by inhibiting T function via its coinhibitory receptor, programmed 1 (PD-1). Some driver gene mutations KRAS have been reported to be involved intrinsic regulation expression. However, potential role precise mechanism mutants expression NSCLC remain obscure. Methods: We first examined key...
Laryngeal squamous cell carcinoma (LSCC) is a common malignant tumor in Northeast China and frequently associated with well-established risk factors like smoking alcohol abuse. Human papilloma virus (HPV) an epitheliotropic oncogenic that has been detected variety of head neck tumors including LSCC. This retrospective study was to investigate the prevalence HPV infection patients In situ hybridization performed 99 LSCC detect expression HPV-16 E6 mRNA. The positive rate HPV16 mRNA 36.36%...
Abstract p21 WAF 1/ CIP 1 (p21) plays critical roles in cell‐cycle regulation and DNA repair is transcriptionally regulated through p53‐dependent or ‐independent pathways. Bioinformatic analysis predicated one stress‐response element ( STRE ) implicated single nucleotide polymorphism SNP rs2395655 of the promoter. Here, we investigated transcriptional regulatory function variant genotype analyzed its associations with expression clinical outcomes esophageal squamous cell carcinoma ESCC...
Objective: To look for the further evidence HPV L1 HPV16 E6, 18 E6 and EBV as carcinogenic factors in laryngeal carcinoma. Method: we examined representative numbers of specimens from cancer with highly sensitive PCR technique presence high-risk types HPV18 LMP1. Results: Using detection, 7.3% samples were positive, 52.03% 30.89% positive 9.13% LMP1 positive. The low incidence high HPV-16 genes suggest that might be integrated into tumor cells. Our results support a role HPV-18 infection...
Tutor system has been widely applied in the cultivation of talents, such as undergraduates, graduate students and young scientist. Scientific research tutor promotes interaction between tutors students, improves level personnel training. In view problems scientists hospital, we established a model by setting mentors. After preliminary practice, more significant results have achieved. Key words: scientific tutor; Hospital; young scientist
Zhangjiakou primary school; Mental health education
目的探讨白细胞介素-6（interleukin-6，IL-6）、降钙素原（procalcitonin，PCT）及C-反应蛋白（C-reactive protein，CRP）对儿童急性阑尾炎（acute appendicitis，AA）伴穿孔的预测价值。 方法以2020年1月1日至2020年12月31日湖南省儿童医院和长沙市第三医院诊断为急性阑尾炎的307例患者作为研究对象，根据是否发生阑尾穿孔分为穿孔组（n=124）和未穿孔组（n=83），比较两组IL-6、PCT、CRP、白细胞计数（white blood cell，WBC）、中性粒细胞比值（neutrophil ratio%，N%）等指标。并根据受试者特征曲线（ROC curve，ROC）判断各指标诊断AA发生穿孔的效能。 结果两组患者年龄、性别比例、白细胞计数、中性粒细胞比值差异无统计学意义（P>0.05）。穿孔组IL-6、PCT及CRP水平高于未穿孔组，差异有统计学意义（P 36.6 pg/mL（OR=3.869，95%CI：1.025~14.597）及CRP>57.9...