A5100681496- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Pediatric health and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Allergic Rhinitis and Sensitization
- Lung Cancer Treatments and Mutations
- Tuberculosis Research and Epidemiology
- Dermatology and Skin Diseases
- Metal-Organic Frameworks: Synthesis and Applications
- Pleural and Pulmonary Diseases
- Helicobacter pylori-related gastroenterology studies
- Covalent Organic Framework Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Lung Cancer Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Liver Disease Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Neonatal Respiratory Health Research
- Carbon Dioxide Capture Technologies
- Gastroesophageal reflux and treatments
- Cystic Fibrosis Research Advances
- Nosocomial Infections in ICU
- Membrane Separation and Gas Transport
Catholic University of Korea
2016-2025
Seoul St. Mary's Hospital
2015-2025
Jeonbuk National University
2020-2023
Jeju National University Hospital
2023
Uijeongbu St. Mary's Hospital
2016-2022
Dongguk University
2022
ORCID
2021
Korea University
2017-2019
Seoul Institute
2018
Government of the Republic of Korea
2017-2018
α-Actinin is tyrosine-phosphorylated in activated human platelets (Izaguirre, G., Aguirre, L., Ji, P., Aneskievich, B., and Haimovich, B. (1999) J. Biol. Chem. 274, 37012–37020). Analysis of platelet RNA by reverse transcription-polymerase chain reaction revealed that α-actinin expressed identical to the cytoskeletal/non-muscle isoform. A construct this isoform containing a His6 tag at amino terminus was generated. Robust tyrosine phosphorylation recombinant protein detected cells treated...
Asthma is a chronic inflammatory airway disease characterized by hyperresponsiveness (AHR), inflammation, and remodeling. There emerging interest in the involvement of transient receptor potential vanilloid 1 (TRPV1) channel pathophysiology asthma. This study examined whether TRPV1 antagonism alleviates asthma features murine model asthma.BALB/c mice were sensitized to challenged ovalbumin develop Capsazepine (TRPV1 antagonist) or small interfering RNA (siRNA) was administered treatment...
Asthma is a chronic airway disease characterized by remodeling, leading to progressive decline in lung function. Therapeutic agents that attenuate remodeling can complement the limited effects of traditional glucocorticoids. In this study, we investigated effect resveratrol on allergic inflammation and murine model bronchial asthma.Peribronchial smooth muscle thickening developed mice challenged with 3-month repeated exposure ovalbumin (OVA) was used study remodeling. Oral administered daily...
Prospective solid adsorbents for CO2 capture require low total regeneration energy that can be achieved by combining high working capacity, a desorption temperature, and narrow temperature difference (ΔT) between regeneration. These materials should critically water-stable because flue gas from coal-fired power plants contains water vapor. Herein, we present the development of diamine-appended metal–organic framework (MOF) adsorbent showed unprecedented performance with record ΔT (30 °C),...
Imaging or drug delivery tools for atherosclerosis based on the plaque biology are still insufficient. Here, we attempted to identify peptides that selectively home atherosclerotic plaques using phage display. A library containing random was ex vivo screened binding human atheroma tissues. After three four rounds of selection, DNA inserts clones wer sequenced. peptide sequence, CRKRLDRNC, most frequently occurring one. Intravenously injected displaying CRKRLDRNC observed aortic tissues...
Pungent constituents of ginger (Zingiber officinale) have beneficial effects on inflammatory pain and arthritic swelling. However, the molecular basis for these pharmacological properties is only partially understood. Here, we investigated target 1-dehydro-[10]-gingerdione (D10G), one pungent ginger, that mediates its suppression NF-κB-regulated expression genes linked to toll-like receptor (TLR)-mediated innate immunity.
Abstract For real‐world postcombustion applications in the mitigation of CO 2 emissions using dry sorbents, adsorption and desorption behaviors should be controlled to design fabricate prospective materials with optimal performances. Herein, we prepared diamine‐functionalized Mg (dobpdc) (H 4 dobpdc=4,4′‐dihydroxy‐(1,1′‐biphenyl)‐3,3′‐dicarboxylic acid). ( 1 ‐diamine) ethylenediamine (en), primary–secondary N ‐ethylethylenediamine—een ‐isopropylethylenediamine—ipen), primary–tertiary,...
Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice. multicenter, retrospective cohort included 136 who received at least 4 months between September 2017 July 2022 25 medical centers affiliated Korean Asthma Registry (KoSAR). The evaluated effects, including acute exacerbation rates, maintenance oral corticosteroid dosages,...
Background The concept of treatable traits has been proposed for managing chronic cough; however, evidence supporting its clinical utility remains limited. This study investigated the relationship between baseline and cough persistence in a prospective registry patients with cough. Methods We analyzed data from 426 enrolled Korean Chronic Cough Registry. Eleven potential were assessed at baseline. primary outcome was persistence, defined as severity Visual Analog Scale (VAS) score >20...
The incidence of cytomegalovirus (CMV) pneumonia is increasing in patients diagnosed with hematologic malignancies. utility CMV-DNA viral load measurement has not been standardized, and cut-off values have established. This study was designed to investigate the CMV quantitative real-time PCR (qRT-PCR) using bronchial washing fluid.We retrospectively reviewed microbiologic pathologic results fluid biopsy specimens addition patients' clinical characteristics.A total 565 qRT-PCR assays were...
Postsulfonation of a porous organic polymer <bold>1E</bold> afforded sulfonated material (<bold>1ES</bold>), which showed an unprecedented superprotonic conductivity 0.159 S cm<sup>−1</sup> at 80 °C and 90% relative humidity.
Aim of the Study: MicroRNA-21 (miR-21) is up-regulated during allergic airway inflammation, reflecting a Th2 immune response. We investigated effects an miR-21 antagomir and its mechanism action in mouse model acute bronchial asthma. Materials Methods: BALB/c mice were sensitized challenged with ovalbumin (OVA). The anti-miR-21 was administered by intranasal inhalation from day sensitization. Changes cell counts, cytokine levels bronchoalveolar (BAL) fluid, hyper-responsiveness (AHR)...
Introduction: Nintedanib is a multi-tyrosine kinase receptor inhibitor recently approved for treatment of idiopathic pulmonary fibrosis. Although angiogenesis key process involved in airway structural changes patients with bronchial asthma, the effect nintedanib targeting angiokinase pathway on inflammation and remodeling has not been evaluated. Methods: We used 3-month ovalbumin (OVA) challenge mouse model remodeling. was orally administrated during period, effects were examined based...
Purpose MicroRNA-21 (miR-21) influences the Th2 immune pathway by suppressing expressions of interleukin (IL)-12 and interferon (IFN)-γ. The effects miR-21 suppression on alveolar macrophage polarization airway inflammation are not known. Methods BALB/c knockout (KO) mice were sensitized challenged with ovalbumin (OVA). anti-miR-21 antagomir was administered to intranasal inhalation from day OVA sensitization. Changes in cell counts, cytokine levels bronchoalveolar lavage fluid (BALF),...
Abstract Background While the clinical characteristics and outcomes of asthma‐chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those COPD or asthma, prevalence features ACO in patients severe asthma are unclear. Objectives Evaluation using Korean registry. Methods At time registration, was determined by attending specialists. Patients were classified into non‐ACO groups, demographic these two groups compared. Results Of 482 23.7% had ACO. group...