A5103201166- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer, Hypoxia, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer Cells and Metastasis
- Inflammatory Biomarkers in Disease Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuroendocrine Tumor Research Advances
- Medical Imaging and Pathology Studies
- Neutropenia and Cancer Infections
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Tuberculosis Research and Epidemiology
- Tracheal and airway disorders
- Cancer therapeutics and mechanisms
- Biomarkers in Disease Mechanisms
- Asthma and respiratory diseases
- Cancer Diagnosis and Treatment
- Diagnosis and treatment of tuberculosis
- Obstructive Sleep Apnea Research
- Colorectal Cancer Treatments and Studies
- Smoking Behavior and Cessation
Catholic University of Korea
2016-2025
Eunpyeong Hospital
2020-2025
Seoul St. Mary's Hospital
2019-2023
Catholic University of America
2023
Moffitt Cancer Center
2012-2023
Uijeongbu St. Mary's Hospital
2012-2021
St. Vincent's Hospital
2021
Yeouido St. Mary's Hospital
2020-2021
Incheon St. Mary's Hospital
2018-2021
St. Mary’s Hospital
2019-2021
Transforming growth factor-β (TGF-β) promotes tumor invasion and metastasis by inducing epithelial-mesenchymal transition (EMT). EMT is often related with acquisition of stemness characteristics. The objective this study was to determine whether characteristics induced TGF-β might be associated epigenetic regulation in lung cancer. A human normal epithelial cell line four cancer lines were treated TGF-β. Transcriptome analysis BEAS-2B A549 cells incubated analyzed through next-generation...
Abstract The purpose of this study was to evaluate whether obstructive sleep apnea (OSA)-related chronic intermittent hypoxia (CIH) influences lung cancer progression and elucidate the associated mechanisms in a mouse model cancer. C57/BL6 mice CIH group were exposed for two weeks after tumor induction compared with control (room air). Hypoxia inducible factor 1α (HIF-1α), vascular endothelial growth (VEGF) metastasis-related matrix metalloproteinases (MMP) measured. expression levels...
ABSTRACT Introduction The provision of treatment for epidermal growth factor receptor (EGFR)‐mutated nonsmall cell lung cancer (NSCLC) patients has increased in Korea. However, multicenter studies on the clinicopathologic dataset and outcomes, using a large‐scale dataset, have not been conducted. current study is prospective retrospective observational cohort that registers all stages EGFR‐mutated NSCLC patients. Methods Korean EGFR Registry was designed to enroll 2000 with from 40...
Background and objectives: This study aimed to compare the efficacy of second-generation anaplastic lymphoma kinase (ALK) tyrosine inhibitors (TKIs) alectinib brigatinib in treatment advanced non-small-cell lung cancer (NSCLC) with ALK rearrangements based on real-world data. Design methods: We conducted a multicenter retrospective using Clinical Data Warehouse from seven university hospitals affiliated Catholic Medical Center. Patients diagnosed ALK-positive NSCLC treated or were included....
Background: Particulate matter (PM) can penetrate deep into the lungs, leading to diseases through induction of hypoxia and inflammation. The hypoxia-inducible factor-1α (HIF-1α) protein is well-established as a key factor in hypoxic response, PM exposure has been linked induction. To develop model suitable for studying PM-induced hypoxia, we compared expression HIF-1α between conventional 2-dimensional (2D) cell culture 3-dimensional (3D) model.Methods: BEAS-2B cells were cultured 2D (using...
This study examined prevalence and risk factors of periodontitis in representative samples Korean adults, with without diabetes mellitus (DM).Data from the 2012 National Health Nutritional Examination Survey were analyzed. A total 4,477 adults (≥ 30 years old) selected 8,057 individuals who completed a nutrition survey, self-reported general health behavior questionnaire, an oral examination, hygiene behaviors laboratory tests. DM was defined as fasting plasma glucose ≥ 126 mg/dL, or...
Although carboplatin is one of the standard chemotherapeutic agents for non-small cell lung cancer (NSCLC), it has limited therapeutic efficacy due to activation a survival signaling pathway and induction multidrug resistance. Curcumin, natural compound isolated from plant Curcuma longa, known sensitize tumors different agents. The aim this study evaluate whether curcumin can chemosensitize cells analyze underlying synergism. We investigated synergistic effect both on proliferation,...
To investigate associations between dyspnea and clinical outcomes in patients with non-small cell lung cancer (NSCLC).From 2001 to 2014, we retrospectively reviewed the prospective database of St. Paul's Hospital at Catholic University Korea. We enrolled NSCLC evaluated symptoms using modified Medical Research Council (mMRC) scores. Also, estimated pulmonary functions analyzed survival data.In total, 457 were enrolled, 259 (56.7%) had dyspnea. Among those whose mMRC scores available (109 no...
Introduction A combination of platelet and lymphocyte to monocyte ratio (LMR) (abbreviated as COP-LMR) has been recently evaluated systemic inflammatory marker for prognostication in lung cancer. While previous study on COP-LMR its prognostic value NSCLC patients who underwent curative resections, the these two markers not advanced yet. Objectives In this study, we stage IV with malignant pleural effusion under active anticancer treatment. Methods Between January 2012 July 2016, 217 MPE...
A hypoxic microenvironment leads to an increase in the invasiveness and metastatic potential of cancer cells within tumors via epithelial-mesenchymal transition (EMT) stemness acquisition. However, hypoxia-induced changes expression function candidate stem cell markers their possible molecular mechanism is still not understood. Lung lines were analyzed normoxic or conditions. For screening among markers, a transcriptome analysis using next-generation sequencing was performed. validation, EMT...
BackgroundPatients with lung cancer experience considerable symptom burden, which can decrease patients' QOL. Our aim was to investigate the association between QOL questionnaire at diagnosis and survival of cancer.Patients MethodsThis a multicenter study patients 7 medical centers Catholic University Korea that responded quality life December 1, 2017 31, 2020. We analyzed 5 functional (physical, role, emotional, cognitive, social functioning) nine (fatigue, nausea vomiting, pain, dyspnea,...
Abstract Background Simultaneous genotyping has advantages in turnaround time and detecting the real mutational prevalence unresectable non‐small‐cell lung cancer (NSCLC), a group not previously genetically characterized. Methods We developed simultaneous panel of screening EGFR KRAS mutations by direct sequencing or PNA clamping, ALK rearrangement fluorescent situ hybridization (FISH) multicenter manner. Results Of 510 NSCLC Korean patients, identified (29.0%) (8.6%) (9.2%). Seven patients...
Lung cancer and chronic obstructive pulmonary disease (COPD) are two major lung diseases. Epidermal growth factor receptor (EGFR) mutations, v-Ki-ras2 Kirsten rat sarcoma (KRAS) mutations anaplastic lymphoma kinase (ALK) gene rearrangements represent driver that frequently assessed on initial evaluation of non-small-cell (NSCLC). The present study focused the expression in NSCLC patients presenting with COPD further evaluated association between COPD. Data from 501 consecutive histologically...
Hypoxia is a critical characteristic of solid tumors with respect to cancer cell survival, angiogenesis, and metastasis. Hyperoxic treatment has been attempted reverse hypoxia by enhancing the amount dissolved oxygen in plasma. In this study, we evaluated effects normobaric hyperoxia on progression lung determine whether toxicity can be used therapy. Following tail vein injection Lewis carcinoma cells, C57BL/6J mice were exposed 24-h hyperoxia/normoxia cycle for two weeks. addition, A549...
Recently, cancer organoid-based drug sensitivity tests have been studied to predict patient responses anticancer drugs. The area under curve (AUC) or IC50 value of the dose-response (DRC) is used differentiate between sensitive and resistant patient's groups. This study proposes a multi-parameter analysis method (cancer diagnosis reactivity prediction, CODRP) that considers stage cell growth rate, which represent severity patients, in test.On CODRP platform, patient-derived organoids (PDOs)...
Abstract Patient-derived organoids (PDOs) are valuable in predicting response to cancer therapy. PDOs ideal models for precision oncologists. However, their practical application guiding timely clinical decisions remains challenging. This study focused on patients with advanced EGFR-mutated non-small cell lung and employed a organoid-based diagnosis reactivity prediction (CODRP)-based oncology platform assess the efficacy of EGFR inhibitor treatments. CODRP was evaluate EGFR-tyrosine kinase...
Hypoxia is a representative tumor characteristic associated with malignant progression in clinical patients. Engineered vitro models have led to significant advances cancer research, allowing for the investigation of cells physiological environments and study disease mechanisms processes enhanced relevance. In this study, we propose U-shape pillar strip 3D cell-lumped organoid model (3D-COM) effects hypoxia on lung high-throughput manner. We developed U-pillar that facilitates aggregation...