A5053083373- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Cancer Mechanisms and Therapy
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Cancer Genomics and Diagnostics
- Occupational and environmental lung diseases
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Radiomics and Machine Learning in Medical Imaging
- Lung Cancer Research Studies
- Medical Imaging and Pathology Studies
- NF-κB Signaling Pathways
- Cancer Cells and Metastasis
Sungkyunkwan University
2024
CHA Vaccine Institute (South Korea)
2024
Samsung (South Korea)
2024
Bio-Medical Science (South Korea)
2021-2023
One major challenge associated with lung cancer organoids (LCOs) is their predominant derivation from surgical specimens of patients early-stage cancer. However, advanced cancer, who are in need chemotherapy, often cannot undergo surgery. Therefore, there an urgent to successfully generate LCOs biopsy specimens. Conventional techniques, such as transthoracic needle and forceps biopsy, only yield small amounts tissue, resulting a low success rate for culturing samples. Furthermore, potential...
Recently, cancer organoid-based drug sensitivity tests have been studied to predict patient responses anticancer drugs. The area under curve (AUC) or IC50 value of the dose-response (DRC) is used differentiate between sensitive and resistant patient's groups. This study proposes a multi-parameter analysis method (cancer diagnosis reactivity prediction, CODRP) that considers stage cell growth rate, which represent severity patients, in test.On CODRP platform, patient-derived organoids (PDOs)...
Abstract Introduction Protein tyrosine kinase 2 (PTK2) plays a pivotal role in various cancers via cross-talk with growth factor signaling pathways. PTK2 is amplified non-small cell lung cancer (NSCLC). However, the functional of has not been elucidated yet. Here, we report that functionally implicated epidermal receptor (EGFR)- and toll-like receptors (TLRs)-mediated for progression cancer. Methods Microarray data NSCLC tumor tissues matched normal 42 patients were used to gain insights...
Background: Patient-derived malignant pleural effusion (MPE) samples can be used to identify a patient-specific drug combination since MPE are readily available and cost-effective tumor cell sources. However, the isolation of target cancer cells from has been inefficient because contain complex mixture immune cells, non-cancerous cells. Hence, new methods need developed effectively isolate that for 3-dimensional (3D) culture. in vitro 3D models expected facilitate more precise...