A5060119833- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- SARS-CoV-2 detection and testing
- HIV-related health complications and treatments
- HIV Research and Treatment
- Long-Term Effects of COVID-19
- Vaccine Coverage and Hesitancy
- Liver Disease Diagnosis and Treatment
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Viral gastroenteritis research and epidemiology
- HIV, Drug Use, Sexual Risk
- Animal Virus Infections Studies
- Viral Infections and Vectors
- Hepatitis C virus research
- Mosquito-borne diseases and control
- Pneumocystis jirovecii pneumonia detection and treatment
- Biosensors and Analytical Detection
- COVID-19 Impact on Reproduction
- Antifungal resistance and susceptibility
- Sepsis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Zoonotic diseases and public health
Chulalongkorn University
2016-2025
King Chulalongkorn Memorial Hospital
2013-2025
Thai Red Cross Society
2017-2025
Armed Forces Research Institute of Medical Science
2021-2022
Ministry of Public Health
2021-2022
HIV Netherlands Australia Thailand Research Collaboration
2022
Bamrasnaradura Infectious Diseases Institute
2022
Keelung Chang Gung Memorial Hospital
2021
Brigham and Women's Hospital
2011-2012
Harvard University
2011-2012
Abstract In the age of a pandemic, such as ongoing one caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), world faces limited supply tests, personal protective equipment, and factories chains are struggling to meet growing demands. This study aimed evaluate efficacy specimen pooling for testing SARS‐CoV‐2 virus, determine whether costs resource savings could be achieved without impacting sensitivity testing. Ten previously tested nasopharyngeal throat swab specimens...
A greater understanding of the antibody response to SARS-CoV-2 in an infected population is important for development a vaccination.To investigate IgA and IgG antibodies Thai patients with differing severities COVID-19.Plasma from following patient groups was examined: 118 adult confirmed infections, 49 under investigation (without infections), 20 other respiratory 102 healthy control patients. Anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA) EUROIMMUN performed assess antibodies....
When severe, COVID-19 shares many clinical features with bacterial sepsis. Yet, secondary infection is uncommon. However, as epithelium injured and barrier function lost, products entering the circulation might contribute to pathophysiology of COVID-19. We studied 19 adults, severely ill patients infection, who were admitted King Chulalongkorn Memorial Hospital, Bangkok, Thailand, between 13th March 17th April 2020. Blood samples on days 1, 3, 7 enrollment analyzed for endotoxin activity...
SARS-CoV-2 infection results in a broad spectrum of clinical outcomes, ranging from asymptomatic to severe symptoms and death. Most COVID-19 pathogenesis is associated with hyperinflammatory conditions driven primarily by myeloid cell lineages. The long-term effects post recovery include various symptoms. We performed longitudinal study the innate immune profiles 1 3 months after Thai cohort comparing patients mild, moderate, using peripheral blood mononuclear cells (n = 62). Significant...
To determine the incidence and risk factors for developing diabetes mellitus in a cohort of Thai HIV-infected patients on long-term combination antiretroviral therapy (cART).Prospective study conducted between July 1996 30 April 2015.A total 1748 (60% men) who did not have prior to ART were assessed twice year. Incident was defined as either having two consecutive fasting glucose levels more than 126 mg/dl, or reporting antidiabetes medication/diabetes diagnosis after starting cART....
We report a case of COVID-19 in kidney transplant patient Thailand. A 58-year-old 2 years post-kidney recipient, with maintenance immunosuppression tacrolimus, mycophenolate mofetil (MMF), and prednisolone, presented acute diarrhea which followed by fever on day 12. Symptoms pneumonia together lymphopenia from complete blood count were developed 7 after onset the x-ray finding bilateral multifocal patchy infiltration. infection has been confirmed reverse real-time polymerase chain reaction...
Inactivated SARS-CoV-2 (CoronaVac®, Sinovac, or SV) and ChAdOx1 nCoV-19 (Vaxzevria®, Oxford-Astra Zeneca, AZ) vaccines have been administered to the health care workers (HCWs).To determine short-term immune response after SV AZ vaccinations in HCWs.In this prospective cohort study, HCWs who completed a 2-dose regimen of were included. Immune was evaluated by surrogate viral neutralization test (sVNT) anti-SARS-CoV-2 total antibody. Blood samples analyzed at 4 12 weeks complete vaccination....
Inactivated SARS-CoV-2 vaccine (CoronaVac) is commonly used in national immunization programs. However, the immune response significantly declines within a few months. Our study assessed against after receiving booster shots of BNT162b2 or ChAdOx1 among health care workers who previously received CoronaVac as their primary immunization. Fifty-six participants and forty-two were enrolled into this study, which evaluated responses, including anti-SARS-CoV-2 spike total antibodies (Elecsys®),...
Emerging coronaviruses (CoVs) are understood to cause critical human and domestic animal diseases; the spillover from wildlife reservoirs can result in mild severe respiratory illness humans animals spread more readily these naïve hosts. A low-cost CoV molecular method that detect a variety of CoVs humans, animals, environmental specimens is an initial step ensure early identification known new viruses. We examine collection 50 human, 46 wastewater, 28 bat, 17 avian archived using 3...
Background The presence of neutralizing antibodies (NAbs) is an indicator protective immunity for most viral infections. A newly developed surrogate neutralization assay (sVNT) offers the ability to detect total receptor binding domain-targeting NAbs in isotype-independent manner, increasing test sensitivity. Thus, specimens with low IgM/ IgG antibody levels showed strong activity sVNT. Methods This study aimed measure %inhibition measured by sVNT PCR-confirmed COVID-19 patients. sensitivity...
Abstract Background Despite protection against severe COVID-19 and SARS-CoV-2 variants in the post-pandemic era, importance of mRNA booster doses may be underestimated. We assessed immunogenicity bivalent original/Omicron BA.4-5 vaccine PLWH by immunosuppression level. Table 1: Baseline Characteristics People Living With Human Immunodeficiency Virus (n = 74) at time administration a original/omicron dose divided into low CD4 group (CD4 T-cell levels ≤200 cells/mm³) high >200...
Abstract Background TDF/3TC/DTG (TLD) has been adopted as the first line of therapy for all PWH according to WHO 2019 and Thai HIV guidelines, hence, in Thailand on TDF/FTC/EFV are opted a switch TLD. However, switching DTG+3TC is not inferior TDF-based ART terms efficacy, but with more favorable renal safety. In this study, we compared estimated glomerular filtration rates (eGFR), virological immunological response, metabolic parameters among currently receiving TDF+FTC or 3TC+EFV who...
Abstract Background Since early May 2022, cases of mpox (monkeypox) have been reported in countries where the disease is not endemic, alongside continued reports from endemic regions. This marks first time that multiple and clusters concurrently both non-endemic across diverse geographical areas. As March 8, 2024, there were 94,776 confirmed globally, with 721 Thailand—most which Bangkok. Figure 1 The phylogenetic tree was constructed 60 Mpox genomes collected Bangkok, Thailand, during...
Abstract Background Antiretroviral therapy (ART) for human immunodeficiency virus (HIV) infection is associated with metabolic changes, including dyslipidemia and cardiovascular risk. Switching from protease inhibitor (PIs)-based regimens to dolutegravir (DTG)-based offers potential benefits, but its impact on parameters requires investigation. This study aimed assess the change in low-density lipoprotein cholesterol (LDL-C) levels, a risk factor disease, people living HIV (PLWH) who...
Wastewater-based epidemiology is a valuable tool for population-level pathogen surveillance, complementing clinical methods. While most sampling focuses on municipal wastewater treatment plants, emerging evidence suggests collected from hospital settings can lead to targeted interventions. To investigate surveillance in further, we tracked the presence and concentration of SARS-CoV-2 RNA across multi-scale sample sites within large, public tertiary care Bangkok, Thailand. From July 2022 May...
Bats act as hosts for various ectoparasites, including bat flies, bugs, fleas, ticks, and mites, which play crucial roles in the transmission of bat-borne pathogens. As obligate blood-feeding parasites, these ectoparasites can serve direct vectors or indirectly influence pathogen dynamics populations. In Thailand, molecular studies on are limited, with scarce data their diversity, distribution, role zoonotic transmission. This study aims to provide first characterization flies other...
People living with HIV (PLWH) exhibit heterogeneous immune responses, influenced by varying degrees of deficiency and viral suppression. The efficacy COVID-19 vaccines in this population remains underexplored, particularly those low CD4 counts. This study assessed the antibody response PLWH T-cell levels ≤200 cells/mm 3 compared to higher levels, following a bivalent mRNA vaccine booster. All participants were on effective Antiretroviral therapy (ART) virologic suppression had received...
<title>Abstract</title> Background Norovirus genogroup II genotype 4 (GII.4) has historically dominated global epidemics over the past decades. However, GII.17 demonstrated significant evolutionary and epidemiological dynamics, particularly with emergence of Kawasaki strain during 2014 outbreaks in Asia. In 2024, GII.17[P17] re-emerged evidence dissemination. Despite its public health relevance, origin, characteristics, genomic drivers remain incompletely understood. Results Our analysis...
TDF/3TC/DTG (TLD) has been adopted as the first-line therapy for all people with HIV according to WHO 2019 and Thai guidelines. As a result, in Thailand on TDF/FTC/EFV are switched TLD. However, increasing data demonstrate efficacy renal safety of TDF-sparing dual DTG + 3TC compared TDF-based combination ART (cART) switching therapy. A direct comparison estimated glomerular filtration rates (eGFR) among treated regimens who switch TLD vs. is yet be made. We enrolled virologically suppressed...
Vitamin D insufficiency plays an important role in liver fibrosis hepatitis C virus (HCV)-infected patients. We assessed by transient elastography and 25 hydroxy vitamin [25(OH)D] status HCV-infected patients, with (HIV/HCV) or without HIV co-infection (HCV) from Thailand.Fibrosis stage was defined as mild (< 7.1 kPa); moderate (7.2-9.4 severe (9.5-14 kPa), cirrhosis (> 14 kPa). Hypovitaminosis 25(OH)D < 30 ng/mL. Logistic regression analyses were used to assess predictors for significant...
Wastewater surveillance is considered a promising approach for COVID-19 in communities. In this study, we collected wastewater samples between November 2020 and February 2022 from twenty-three sites the Bangkok Metropolitan Region to detect presence of SARS-CoV-2 its variants comparison standard clinical sampling. A total 215 were tested RNA by real-time PCR with three targeted genes (N, E, ORF1ab); 102 positive (42.5%). The determined multiplex MassARRAY assay distinguish four variants,...