A5044963170- Genetic Mapping and Diversity in Plants and Animals
- Rice Cultivation and Yield Improvement
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- SARS-CoV-2 and COVID-19 Research
- Plant Stress Responses and Tolerance
- DNA Repair Mechanisms
- GABA and Rice Research
- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Genomics and Chromatin Dynamics
- RNA Research and Splicing
- COVID-19 Clinical Research Studies
- Connective tissue disorders research
- Glycogen Storage Diseases and Myoclonus
- PARP inhibition in cancer therapy
- Genomics and Rare Diseases
- Cancer-related molecular mechanisms research
- Genetic and phenotypic traits in livestock
- Gene expression and cancer classification
- Drug Transport and Resistance Mechanisms
- interferon and immune responses
- Pharmacogenetics and Drug Metabolism
- Neurological disorders and treatments
- Environmental DNA in Biodiversity Studies
Chulalongkorn University
2016-2025
King Mongkut's University of Technology North Bangkok
2013
Siriraj Hospital
2013
Mahidol University
2013
North Carolina State University
2010-2012
University of North Carolina at Chapel Hill
2010
Benign adult familial myoclonic epilepsy (BAFME) is an autosomal disorder characterized by adult-onset cortical tremor and generalized seizures. Using whole genome sequencing, Yeetong et al. identify the causative mutation for type 4 of (BAFME4), providing insights into underlying pathogenesis.
Salt stress, a major plant environmental is critical constraint for rice productivity. Dissecting the genetic loci controlling salt tolerance in improving productivity, especially at flowering stage, remains challenging. Here, we conducted genome-wide association study (GWAS) of based on exome sequencing Thai accessions. Photosynthetic parameters and cell membrane stability under stress stage; yield-related traits 104 (Oryza sativa L.) accessions belonging to indica subspecies were...
Pigmented rice (Oryza sativa L.) is recognized as a source of natural antioxidant compounds, such flavonoids, oryzanol, tocopherol, and anthocyanin. Because their nutritional benefits, anthocyanin-enriched or pigmented varieties are feasible alternatives for promoting human health. Pigment biosynthesis in complex process that involves multiple biosynthetic regulatory genes. This study aimed to identify the genes associated with traits local Thai develop molecular markers breeding programs....
Global DNA hypomethylation promoting genomic instability leads to cancer and deterioration of human health with age. Aim: To invent a biotechnology that can reprogram this process. Methods: We used Alu siRNA direct interspersed repetitive sequences methylation in cells. evaluated the correlation between damage levels. Results: observed an inverse element endogenous white blood Cells transfected exhibited high levels, increased proliferation, reduced improved resistance damaging agents....
The endogenous DNA damage triggering an aging progression in the elderly is prevented youth, probably by naturally occurring gaps. Decreased gaps are found during chronological yeast. So we named "Youth-DNA-GAPs." hidden histone deacetylation to prevent break response and were also reduced cells lacking either high-mobility group box (HMGB) or NAD-dependent deacetylase, SIR2. A reduction results shearing strands decreasing cell viability. Here, show roles of genomic stability prevention...
Abstract Background Benign adult familial myoclonic epilepsy (BAFME) is an autosomal dominant disorder characterized by cortical tremors and seizures. Six types of BAFME, all caused pentanucleotide repeat expansions in different genes, have been reported. However, several other BAFME cases remain with no molecular diagnosis. Objectives We aim to characterize clinical features identify the mutation causing a large Malian family 10 affected members. Methods Long‐read whole genome sequencing,...
Background: Diagnosing adult-onset muscular dystrophies is often challenging due to phenotypic overlap and the unavailability of parental samples for genetic phasing in recessive disorders.Case Presentation: A 49-year-old man presented with progressive proximal muscle weakness. Initially misdiagnosed as inflammatory myopathy, he did not respond immunosuppressive treatment. To evaluate a clinical suspicion facioscapulohumeral dystrophy (FSHD1), long-read genome sequencing was performed using...
Abstract Motivation: The quality control (QC) filtering of single nucleotide polymorphisms (SNPs) is an important step in genome-wide association studies to minimize potential false findings. SNP QC commonly uses expert-guided filters based on variables [e.g. Hardy–Weinberg equilibrium, missing proportion (MSP) and minor allele frequency (MAF)] remove SNPs with insufficient genotyping quality. rationale the expert sensible concrete, but its implementation requires arbitrary thresholds does...
Unfavourable environmental conditions, including soil salinity, lead to decreased rice (Oryza sativa L.) productivity, especially at the reproductive stage. In this study, we examined 30 varieties, which revealed significant differences in photosynthetic performance responses under salt stress conditions during stage, ultimately affected yield components after recovery. with a correlation between net rate (PN) and intercellular CO2 concentration (Ci) stress, PN was found be negatively...
The mechanism that causes genomic instability in nondividing aging cells is unknown. Our previous study of mutant yeast suggested 2 types replication-independent endogenous DNA double-strand breaks (RIND-EDSBs) exist and they play opposing roles. first type, known as physiologic RIND-EDSBs, were ubiquitous the G0 phase both human certain locations may act epigenetic markers. Low RIND-EDSB levels found mutants lacked chromatin-condensing proteins, such high-mobility group box (HMGB) proteins...
Osteogenesis imperfecta (OI) is a collagen-related bone dysplasia leading to susceptibility fractures. OI can be caused by mutations in several genes including BMP1. It encodes two isoforms, morphogenetic protein 1 (BMP1) and mammalian tolloid (mTLD); both have proteolytic activity remove the C-propeptide from procollagen. We report Thai patient who had his first fracture at age of three months. Using next generation sequencing, we successfully identified novel compound heterozygous BMP1...
Publicly available pharmacogenomics (PGx) databases enable translation of genotype data into clinically actionable information. As variation within pharmacogenes is population-specific, this study investigated the spectrum 25 relevant in Thai population (n = 291) from whole genome sequencing. The bioinformatics tool Stargazer was used for phenotype prediction, through assignment alleles and detection structural variation. Known unreported potentially deleterious PGx variants were identified....
Salt stress is a major limiting factor in crop production and yield many regions of the world. The objective this study was to identify genes responsible for salt tolerance Thai rice populations. We performed genome-wide association with growth traits, relative water content, cell membrane stability at seedling stage, predicted 25 putative genes. Eleven them were located within previously reported salt-tolerant QTLs (ST-QTLs). OsCRN, outside ST-QTLs, selected gene characterization using...
Abstract Context Congenital adrenal hyperplasia is most commonly caused by 21-hydroxylase deficiency (21-OHD), an autosomal recessive disorder resulting from biallelic pathogenic variants (PVs) in CYP21A2. With a highly homologous pseudogene and various types of single nucleotide complex structural variants, identification PVs CYP21A2 has been challenging. Objective To leverage long-read next-generation sequencing combined with locus-specific polymerase chain reaction (PCR) to detect...
Rice (Oryza sativa L.) is the main source of energy for humans and a staple food high cultural significance much world’s population. with highly resistant starch (RS) beneficial health can reduce risk disease, especially type II diabetes. The identification loci affecting properties will facilitate breeding high-quality health-supportive rice. A genome-wide association study (GWAS) 230 rice cultivars was used to identify candidate properties. apparent amylose content (AAC) among ranged from...
Introduction Owing to advances in high-throughput genome sequencing, QTL-Seq mapping of salt tolerance traits is a major platform for identifying soil-salinity QTLs accelerate marker-assisted selection salt-tolerant rice varieties. We performed QTL-BSA-Seq the seedling stage from genetic cross extreme salt-sensitive variety, IR29, and “Jao Khao” (JK), Thai variety. Methods A total 462 F 2 progeny grown soil treated with 160 mM NaCl were used as QTL population. Two high- low-bulk sets, based...
Macrophage plasticity is a process that allows macrophages to switch between two opposing phenotypes based on differential stimuli. Interferon gamma (IFNγ)-primed stimulated with lipopolysaccharide (LPS) (M(IFNγ +LPS)) produce high levels of proinflammatory cytokines such as IL-12, TNFα and IL-6 low the anti-inflammatory cytokine IL-10, while those LPS in presence immune complex (IC) +LPS+IC)) IL-10 IL-12. In this study, we investigated M(IFNγ +LPS) +LPS+IC) vitro compared one active histone...
Replication-independent endogenous double-strand breaks (RIND-EDSBs) occur in both humans and yeast the absence of inductive agents DNA replication. In human cells, RIND-EDSBs are hypermethylated, preferentially retained heterochromatin unbound by γ-H2AX. single gene deletion strains, RIND-EDSB levels altered; number is higher strains with deletions histone deacetylase, endonucleases, topoisomerase, or repair regulators, but lower high-mobility group box proteins Sir2. summary, different...
Abstract Genetic diversity is important for developing salt‐tolerant rice ( Oryza sativa L.) cultivars. Certain Thai accessions display salt tolerance at the adult or reproductive stage, but their response to salinity seedling stage unknown. In this study, a total of 10 cultivars/line, including eight cultivars and standard cultivar susceptible line, were screened using hydroponic system identify genotypes stage. Different morphophysiological indicators used classify tolerant genotypes....
Differences in drug responses individuals are partly due to genetic variations pharmacogenes, which differ among populations. Here, genome sequencing of 171 unrelated Thai from all regions Thailand was used call star alleles 51 pharmacogenes by Stargazer, determine allele and genotype frequencies, predict phenotype compare high-impact variant frequencies between other Three control genes, EGFR, VDR, RYR1, were used, giving consistent results. Every individual had at least three genes with or...