A5058992964- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Anesthesia and Pain Management
- Eosinophilic Esophagitis
- Drug-Induced Adverse Reactions
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Allergic Rhinitis and Sensitization
- Nausea and vomiting management
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Contact Dermatitis and Allergies
- Nonlinear Optical Materials Research
- IL-33, ST2, and ILC Pathways
- Inhalation and Respiratory Drug Delivery
- Cardiac, Anesthesia and Surgical Outcomes
- Spinal Hematomas and Complications
- Dysphagia Assessment and Management
- Anesthesia and Sedative Agents
- Voice and Speech Disorders
- Food Allergy and Anaphylaxis Research
- Shoulder Injury and Treatment
- Diverse Approaches in Healthcare and Education Studies
- Orthopedic Surgery and Rehabilitation
- SARS-CoV-2 and COVID-19 Research
Ulsan College
2011-2025
University of Ulsan
2011-2025
Asan Medical Center
2011-2025
Seoul National University Hospital
2024-2025
Nationwide Children's Hospital
2023
National Research Institute of Fire and Disaster
2021-2022
Daegu TechnoPark
2021
Korea Electronics Technology Institute
2021
Daegu Fatima Hospital
2010-2020
Weatherford College
2020
BACKGROUND: We performed a prospective survey on the adverse reactions following first dose of two types vaccines against coronavirus disease 2019 (COVID-19) in healthcare workers (HCWs) South Korea. METHODS: HCWs at tertiary referral hospital Seoul, Korea, received chimpanzee adenovirus-vectored vaccine (ChAdOx1 nCoV-19) or an mRNA-based (BNT162b2) between March 5 and 26, 2021. The were asked to report through mobile self-report questionnaire for three days after vaccination. RESULTS: A...
ABSTRACT In order to define the contributions of mechanisms for carbapenem resistance in clinical strains Pseudomonas aeruginosa , we investigated presence OprD, expressions MexAB-OprM and MexEF-OprN systems, production β-lactamases 44 strains. All carbapenem-resistant isolates showed loss or decreased levels OprD. Three overexpressed efflux system by carrying mutations mexR . These three had amino acid substitution MexR protein, Arg (CGG) → Gln (CAG), at position 70. None isolates, however,...
Recent evidence suggests that cough hypersensitivity may be a common feature of chronic in adults. However, the clinical relevance remains unclear. This study evaluated cough-related symptom profile and impact adults with cough.This cross-sectional multi-center compared laryngeal sensations triggers patients unexplained following investigations unselected newly referred for cough. A structured questionnaire was used to assess abnormal triggers. Patients were also using Leicester Cough...
We conducted a prospective, mobile-based survey on the self-reported adverse reactions in healthcare workers (HCWs) who received both doses of BNT162b2 mRNA vaccine. Of 342 HCWs completed two-dose vaccination, 265 (77.5%) responded to at least once. Overall, rates were higher after second dose compared with first (89.1% vs. 80.1%, P = 0.006). The most common systemic muscle ache (69.1%), fatigue (65.7%), headache (48.7%), chills (44.2%), and fever (32.1%), notably more vaccine as well. also...
Two hundred ninety isolates of Escherichia coli were investigated for the production extended-spectrum beta-lactamases (ESBLs). Fourteen (4.8%) 290 strains found to produce ESBLs. Each 14 produced one or two ESBLs, as follows: 10 TEM-52, 1 strain SHV-2a, SHV-12, a CMY-1-like enzyme, and expressed SHV-2a enzyme. Another which MICs ceftazidime cefoxitin high, probable AmpC enzyme hyperproducers. Because high prevalence TEM-52 in E. isolates, we further TEM-type ESBLs by Klebsiella pneumoniae...
Chronic cough is a prevalent condition in the community and may pose considerable impairment to quality of life (QoL). However, its disease burden remains largely undefined general population. The present study investigated relationship between chronic health-related QoL Korean nationwide population database, with an emphasis on clinical conditions which confound impact cough.This analyzed cross-sectional datasets adults (aged ≥ 40 years) National Health Nutrition Examination Survey...
Abstract Patients with severe eosinophilic asthma often require systemic medication, including corticosteroids and anti-type 2 (T2) cytokine biologics, to control the disease. While anti-IL5 anti-IL4Rα antibodies suppress effects of IL-4, IL-5 IL-13, molecular pathways modified by these biologics that are associated clinical improvement remain unclear. Therefore, we aimed describe T2-targeting on gene expression blood immune cells. We conducted single-cell RNA sequencing (scRNA-seq)...
Background The relationship between pre-treatment levels of blood eosinophil count (BEC), fractional exhaled nitric oxide (FeNO), and sputum eosinophils (Sp-EOS) treatment response to monoclonal antibodies (mAbs) in severe eosinophilic asthma (SEA) remain unclear. Objective We evaluated BEC, FeNO, Sp-EOS, their combinations as predictors responses patients with SEA undergoing anti-IL5/IL5Rα or anti-IL-4Rα antibody therapies. Methods study included 153 adult (59 94 anti-IL4Rα users). Logistic...
Background The concept of treatable traits has been proposed for managing chronic cough; however, evidence supporting its clinical utility remains limited. This study investigated the relationship between baseline and cough persistence in a prospective registry patients with cough. Methods We analyzed data from 426 enrolled Korean Chronic Cough Registry. Eleven potential were assessed at baseline. primary outcome was persistence, defined as severity Visual Analog Scale (VAS) score >20...
Background: Airway remodeling in asthma is induced by the production of vascular endothelial growth factor, and this process mediated neuropilin-1 (NRP-1). Objective: To investigate association between serum level NRP-1 clinical characteristics asthma. Methods: We measured performed subgroup analysis according to 421 patients registered Cohort for Reality Evolution Adult Asthma Korea. Results: The was significantly higher group under 65 years age than over (1628.36 ± 589.51 vs 1416.75...
Background Opioids are widely used in boluses and patient-controlled analgesia (PCA) for postoperative pain control. In this study, we compared the effects of oxycodone fentanyl on patients with intravenous (IV-PCA) after laparoscopic gynecological surgery. Methods Seventy-four undergoing elective total hysterectomy or myomectomy were randomly assigned to administration either using IV-PCA (potency ratio 1 : 60). The cumulative dose administered mode during initial 48 hours operation was...
Long coronavirus disease (COVID) refers to an array of variable and fluctuating symptoms experienced after acute illness, with signs that persist for 8-12 weeks are not otherwise explicable. Cough is the most common symptom COVID-19, but cough may in some individuals or months recovery from phase. Long-COVID patients get stigmatised because public fear contagion reinfection. However, clinical characteristics longitudinal course long-COVID have been reported detail, evidence-based treatment...
Cough is one of the most common symptoms acute coronavirus disease 2019, but cough may persist for weeks or months. This study aimed to examine clinical characteristics patients with post-coronavirus (COVID) persistent in Omicron era. We conducted a pooled analysis comparing 3 different groups: 1) prospective cohort post-COVID (> weeks; n = 55), 2) retrospective 66), and 3) non-COVID chronic (CC) 8 100). health status was assessed using patient-reported outcomes (PROs). Outcomes, including...
Abstract Different patterns of bacterial communities have been reported in the airways and gastrointestinal tract asthmatics when compared to healthy controls. However, blood microbiome is yet be investigated. Therefore, we aimed determine whether a distinct serum observed by metagenomic analysis extracellular vesicles (EVs). We obtained from 190 adults with asthma 260 controls, which EVs were isolated analyzed. The composition was significantly different that Chao 1 index higher group,...
Severe asthma represents an important clinical unmet need despite the introduction of biologic agents. Although advanced omics technologies have aided researchers in identifying clinically relevant molecular pathways, there is a lack integrated approach severe particularly terms its evolution over time. The collaborative Korea–UK research project Precision Medicine Intervention Asthma (PRISM) was launched 2020 with aim phenotypes by analysing multi-omics data encompassing genomics,...