A5037986323- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Bone health and osteoporosis research
- Vitamin D Research Studies
- Estrogen and related hormone effects
- Bone health and treatments
- Body Composition Measurement Techniques
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Peroxisome Proliferator-Activated Receptors
- Systemic Lupus Erythematosus Research
- Cholesterol and Lipid Metabolism
- Cancer, Hypoxia, and Metabolism
- Bone and Joint Diseases
- Hypothalamic control of reproductive hormones
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- Exercise and Physiological Responses
- Diabetes Management and Education
- Cardiovascular Disease and Adiposity
- Platelet Disorders and Treatments
- Cancer Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
University of New Mexico
2012-2025
New Mexico VA Health Care System
2015-2025
Hospital Universitario de San Vicente Fundación
2023-2025
Universidad de Antioquia
2023-2025
Raymond G. Murphy VA Medical Center
2024
Baylor College of Medicine
2023
Universidad de La Sabana
2021
Biomedical Research Institute of New Mexico
2012-2015
PharmacoGenetics (China)
2015
University of Colorado Health
2007
Obesity causes frailty in older adults; however, weight loss might accelerate age-related of muscle and bone mass resultant sarcopenia osteopenia.In this clinical trial involving 160 obese adults, we evaluated the effectiveness several exercise modes reversing preventing reduction induced by loss. Participants were randomly assigned to a weight-management program plus one three programs - aerobic training, resistance or combined training control group (no program). The primary outcome was...
α-Actinin is tyrosine-phosphorylated in activated human platelets (Izaguirre, G., Aguirre, L., Ji, P., Aneskievich, B., and Haimovich, B. (1999) J. Biol. Chem. 274, 37012–37020). Analysis of platelet RNA by reverse transcription-polymerase chain reaction revealed that α-actinin expressed identical to the cytoskeletal/non-muscle isoform. A construct this isoform containing a His6 tag at amino terminus was generated. Robust tyrosine phosphorylation recombinant protein detected cells treated...
Although obesity is associated with high bone mass, recent reports suggest an increase in the incidence of fractures obese patients. The objectives study were to evaluate influence increasing body fat on mineral density (BMD) and determine different adipokines BMD frail elderly This a cross-sectional baseline characteristics patients participating lifestyle therapy diet or without exercise conducted university setting. One hundred seventy-three, (≥65 y old), (body mass index ≥30 kg/m2) who...
Weight loss therapy of older adults with obesity is limited by weight loss-induced decrease in bone mineral density (BMD), which could exacerbate ongoing age-related and increase the risk for fractures. Therefore, it recommended that should include an intervention such as regular exercise to reduce concomitant loss. However, most appropriate types combine this population unknown. In a randomized controlled trial, we performed head-to-head comparison aerobic or resistance exercise, both,...
Abstract Background Obesity exacerbates age-related effects on body composition and physical metabolic function. Which exercise mode is most effective in mitigating these deleterious changes dieting older adults with obesity unknown. Methods In a randomized controlled trial, we performed head-to-head comparison of aerobic (AEX), resistance (REX), or combination (COMB) during matched ~10% weight loss 160 obese adults. Prespecified analyses compared 6-month intermuscular adipose tissue (IMAT)...
We previously reported that PRDM16 mediated the improvement in body composition testosterone (T)-treated hypogonadal men by shifting adipogenesis to myogenesis. Previous preclinical studies suggest Prdm16 regulates Runx2, an important osteoblastic transcription factor, expression and activity. However, changes PRDM16, other genes/proteins involved osteoblastogenesis with T therapy are unexplored. investigated role of RUNX2 activation measuring gene peripheral blood monocytes (PBMCs) proteins...
Objective To assess the effectiveness of modified National Institute Health (mNIH) activity and chronicity scoring system in predicting progression to end-stage kidney disease (ESKD) Latin American lupus nephritis (LN) patients. Methods We retrospectively analyzed 412 patients with biopsy-proven LN. ESKD was defined as an estimated glomerular filtration rate (eGFR) < 15 mL/min/1.73 m 2 for ≥3 months, dialysis >3 or transplant. Univariable multivariable Cox proportional hazards...
Objective Because the aromatase enzyme catalyzes conversion of testosterone to estradiol (E 2 ), activity this could be important in musculoskeletal health men with low testosterone. The objective present study is determine influence on bone mineral density (BMD) and body composition patients hypogonadism. Design Cross-sectional study. Methods baseline data 90 between 40 74 years old who participated a genetic response therapy (i.e., <300 ng/dl) were analyzed. BMD measured by dual-energy...
Intramuscular triglyceride (IMTG) deposition in skeletal muscle is associated with obesity and type 2 diabetes (T2DM) thought to be related insulin resistance (IR). Curiously, despite enhanced sensitivity, highly trained athletes calorie-restricted (CR) monkeys also have increased IMTG. Sterol regulatory element-binding proteins (SREBPs) are transcription factors that regulate the biosynthesis of cholesterol fatty acids. SREBP-1 by vitro IR subjects, but expression has not been examined...
Skin-to-skin contact (SSC) compared to separation at birth has a positive effect on breastfeeding. However, is common with negative impact The aim was determine the of immediate SSC early duration exclusive breastfeeding.A randomized multicentre parallel clinical trial conducted in two hospitals Cundinamarca (Colombia) between November 2018 and January 2020. Low-risk full term newborns were included. Neonates assigned (in first minute after birth) or onset (start exactly 60 min life) skin...
In this study, we evaluated the independent and combined effects of baseline circulating gonadal, anabolic hormones adipokines on physical function in 107 frail, obese (BMI ≥ 30 kg/m 2 ), older (≥65 yr) subjects. Our results showed significant positive correlations between testosterone insulin growth factor-1 (IGF-1) with knee flexion, extension, one-repetition maximum (1-RM), peak oxygen consumption (VO peak), while no correlation was observed estradiol. Among adipokines, high sensitivity...
Objective: Estradiol (E2) regulates adipose tissue resulting in increased fat mass (FM) with declining E2. However, visceral and hyperestrogenemia are features of obese individuals. It is possible that adipocytes individuals less sensitive to E2 higher FM. Our objective identify the range serum for which postmenopausal women have lowest FM best body composition. Methods: Cross-sectional data from 252 community-dwelling women, 42-90 yo. Subjects were stratified into categories E2(pg/ml):...
Abstract Context Male hypogonadism is associated with low bone mineral density (BMD) and increased fragility fracture risk. Patients type 2 diabetes (T2D) have relatively higher BMD, but greater Objective Evaluate the skeletal response to testosterone therapy in hypogonadal men T2D compared without T2D. Methods Single arm, open-label clinical trial (NCT01378299) involving 105 (40-74 years old), average morning &lt;300 ng/dL. Subjects were injected intramuscularly cypionate (200 mg) every...
Context Male hypogonadism adversely affects body composition, bone mineral density (BMD), and metabolic health. A previous report showed that pre-treatment testosterone (T) levels of &lt;200 ng/dl is associated with greater improvement in spine BMD T therapy. However, to date, there no study investigates whether baseline also influence composition response Objective The aim this determine if are differences the changes profile, turnover markers, addition BMD, therapy men a level...
The integrin αIIbβ3 mediates tyrosine phosphorylation of a 105-kDa protein (pp105) in activated platelets. We have partially purified tyrosine-phosphorylated from platelets stimulated with phorbol 12-myristate 13-acetate and obtained the sequence an internal 12-mer peptide derived this protein. was identical to human α-actinin sequences deposited Swiss Protein Database. α-Actinin, platelets, subsequently by four sequential chromatographic steps. Fractions were analyzed Western blotting...
Background Testosterone (T) therapy increases lean mass and reduces total body truncal fat in hypogonadal men. However, the underlying molecular mechanisms for reciprocal changes humans are not entirely clear. Methods Secondary analysis of specimens obtained from a single-arm, open-label clinical trial on pharmacogenetics response to T men with late-onset hypogonadism, conducted between 2011 2016 involving 105 (40-74 years old), who were given intramuscular cypionate 200 mg every 2 weeks 18...
Aim: Intramyocellular triglyceride (IMTG) correlates with insulin resistance, but there is no clear causal relationship. Insulin resistance and associated hyperinsulinaemia may increase IMTG, via the insulin‐regulated transcription factor, sterol regulatory element–binding protein 1 (SREBP‐1). PPAR agonists also affect IMTG changes in sensitivity, SREBP‐1 or other factors. Methods: We examined skeletal muscle expression, metabolic parameters Zucker diabetic fatty rats (ZDF) after 25 weeks of...