A5017291557- Cardiac Imaging and Diagnostics
- Coronary Interventions and Diagnostics
- Parkinson's Disease Mechanisms and Treatments
- Cardiovascular Disease and Adiposity
- RNA regulation and disease
- Nutrition and Health in Aging
- Cardiovascular Issues in Pregnancy
- Cardiovascular Function and Risk Factors
- Inflammatory Myopathies and Dermatomyositis
- Cholesterol and Lipid Metabolism
- Genetic Neurodegenerative Diseases
- Frailty in Older Adults
- Cardiac Arrhythmias and Treatments
- Peroxisome Proliferator-Activated Receptors
- Nerve injury and regeneration
- Heart Rate Variability and Autonomic Control
- Thermal Expansion and Ionic Conductivity
- Blood Pressure and Hypertension Studies
- Parkinson's Disease and Spinal Disorders
- Atrial Fibrillation Management and Outcomes
- Vascular anomalies and interventions
- Signaling Pathways in Disease
- Contact Dermatitis and Allergies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Alzheimer's disease research and treatments
Ajou University
2014-2023
Peripartum cardiomyopathy (PPCM) is a fatal maternal complication, with left ventricular systolic dysfunction (LVSD; Left ejection fraction 45% or less) occurring at the end of pregnancy in months following delivery. The scarcity screening tools for PPCM leads to delayed diagnosis and increases its mortality morbidity. We aim evaluate an electrocardiogram (ECG)-deep learning model (DLM) detecting peripartum period.For DLM development internal performance test LVSD, we obtained dataset...
Frequent exacerbation is an important phenotype in chronic obstructive pulmonary disease (COPD), while emphysema associated with many comorbidities and lung function decline.To investigate unique features of frequent exacerbators test the hypothesis that emphysematous exacerbations COPD.A total 380 COPD patients were recruited from 16 hospitals Korea June 2005 to April 2012 for analysis. We searched independent predictors comparison non-exacerbators.As severity increased, forced expiratory...
Both immediate and delayed hypersensitivity reactions to iodinated contrast media (ICM) are relatively common. However, there few data determine the clinical utility of immunologic evaluation ICM. To evaluate ICM skin testing in patients with hypersensitivity, 23 (17 6 reactions) were enrolled from 3 university hospitals Korea. With commonly used including iopromide, iohexol, ioversol, iomeprol, iopamidol iodixanol, prick (SPT), intradermal (IDT) patch tests performed. Of 10 anaphylaxis,...
Febrile neutropenia (FN) is the major toxicity of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) regimen in treatment diffuse large B-cell lymphoma (DLBCL). The prediction FN mandatory to continue planned R-CHOP therapy resulting successful anti-cancer treatment. clinical features patterns from 181 DLBCL patients treated with were analyzed retrospectively. Sixty percent (60.2%) experienced at least one episode grade 4 neutropenia. Among them, 42.2%...
Incident depression has been reported to be associated with poor prognosis in patients cardiovascular disease (CVD), which might beta-blocker therapy. Because early detection and intervention can alleviate the severity of depression, we aimed develop a machine learning (ML) model predicting onset major depressive disorder (MDD). A based on L1 regularized logistic regression was trained against South Korean nationwide administrative claims database identify risk factors for incident MDD after...
(1) Background: Currently, limited data are available regarding the relationship between epicardial fat and plaque composition. The aim of this study was to assess visceral surrounding heart lipid core burden in patients with coronary artery diseases; (2) Methods: Overall, 331 undergoing angiography combined near-infrared spectroscopy intravascular ultrasound imaging were evaluated for adipose tissue (EAT) thickness using transthoracic echocardiography. Patients divided into thick EAT thin...
Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. PD pathologically characterized by death midbrain dopaminergic neurons and accumulation intracellular protein inclusions called Lewy bodies or neurites. The major component α-synuclein (α-syn). Prion-like propagation α-syn has emerged as a novel mechanism in progression PD. This been investigated to reveal factors that initiate pathology with aim preventing further Here, we demonstrate coxsackievirus B3 (CVB3)...
Background A biphasic, U-shape relationship has been reported between body mass index (BMI) and clinical outcomes following percutaneous coronary intervention (PCI). However, the waist circumference (WC) cardiovascular risk PCI not reported. Methods prospective cohort study was performed. major adverse cardiac event (MACE) defined as a composite of death (CD), nonfatal myocardial infarction (NFMI) target vessel revascularization (TVR). Patients were evenly divided into 4 groups according to...
Frailty is an issue in patients with heart failure (HF). A Korean version of the frailty scale (K-FRAIL) has been developed.We aimed to analyze relationship between K-FRAIL and physical performance HF.This study included 142 HF aged ≥65 years from a single center. Muscular fitness was assessed using handgrip test knee extensor strength measurement. Aerobic capacity cardiopulmonary exercise 6-min walk (6MWT). questionnaire.Peak VO2 6MWT scores significantly decreased as worsened, but did not....
Although overt hyperthyroidism adversely affects a patient's prognosis, thyroid function tests (TFTs) are not routinely conducted. Furthermore, vague symptoms of often lead to being overlooked. An electrocardiogram (ECG) is commonly used screening test, and the association between ECG well known. However, it difficult for clinicians detect through subtle changes. For early detection hyperthyroidism, we aimed develop validate an electrocardiographic biomarker based on deep learning model...
The presence of protein inclusions, called Lewy bodies (LBs) and neurites (LNs), in the brain is main feature Parkinson's disease (PD). Recent evidence that prion-like propagation α-synuclein (α-syn), as a major component LBs LNs, plays an important role progression PD has gained much attention, although molecular mechanism remains unclear. In this study, we evaluated whether neuronal ApoE regulates cell-to-cell transmission α-syn explored its using vitro vivo model systems. We demonstrate...
Inflammatory myopathy is characterized by symmetrical proximal muscle weakness, elevated enzyme levels and favorable response to glucocorticoids therapy. Although periorbital edema a common manifestation of inflammatory myopathy, generalized subcutaneous very rare. We report here case 47-year-old female patient with acute polymyositis/systemic lupus erythematosus overlap syndrome interstitial lung disease. aggressively treated the disease high-dose glucocorticoids, intravenous...
It remains unclear whether atherosclerotic plaque structure or composition is related to translesional biomechanical stresses in coronary artery disease. The aim of this study was evaluate the association between pressure parameters (using a wire) and characteristics combined near-infrared spectroscopy [NIRS] intravascular ultrasound [IVUS] imaging catheter).Fractional flow reserve (FFR), delta (Δ) FFR, Δ were obtained during adenosine-induced maximum hyperemic status. Lipid core burden...
The optimal duration of dual-antiplatelet therapy (DAPT) after implantation a drug-eluting stent (DES), especially recently developed polymer-free DESs, is unknown. This study examined the efficacy and safety 3- versus 6-month DAPT in patients implanted with Coroflex ISAR DESs.
Abstract Background Parkinson's disease (PD) is one of the most common neurodegenerative disease. PD pathologically characterized by death midbrain dopaminergic neurons and accumulation intracellular protein inclusions called Lewy bodies or neurites. The major component α-synuclein (α-syn). Prion-like propagation α-syn has emerged as a novel mechanism in progression PD. Targeting this could enable development disease-modifying therapies for patients with Nevertheless, initial triggers LB...
Anemia is a common cause of referrals to gastroenterologists. Only small number anemia cases result from vascular abnormalities. Visceral artery aneurysms and pseudoaneurysms are rare forms disease that have significant potential for rupture, resulting in potentially life-threatening hemorrhaging. We present the case 70-year-old female patient with pseudoaneurysm superior mesenteric complicated who had no abdominal pain only anemia. (Korean J Med 2015;88:560-563)
Abstract Aims The clinical meaning of a trans-stent pressure gradient after DES implantation has not been estimated adequately. We evaluated the usefulness fractional flow reserve (FFR) across stent (ΔFFRstent) for long-term outcomes percutaneous coronary intervention (PCI) with drug-eluting (DES). Methods and results FFR pull-back intravascular ultrasound (IVUS) were performed successful PCI in 135 left anterior descending artery lesions. ΔFFRstent was defined as stent. ΔFFRstent/length...
Abstract Background Frailty is known to be an important prognostic indicator in heart failure (HF). The Korean version of the frail scale for Koreans (K-FRAIL) has been developed and verified. purpose this study analyze relationship between K-FRAIL physical performance, including muscular fitness aerobic capacity patients with HF. Methods This included 143 HF aged over 65 years from a single tertiary hospital. In these subjects, was assessed using handgrip test knee extensor strength...