A cytocompatible method of surface-initiated, activator regenerated by electron transfer, atom transfer radical polymerization (SI-ARGET ATRP) is developed for engineering cell surfaces with synthetic polymers. Dopamine-based ATRP initiators are used both introducing the initiator onto chemically complex uniformly (by material-independent coating property polydopamine) and protecting cells from attack during radical-scavenging polydopamine). Synthetic polymers grafted surface individual...

Cell nanoencapsulation provides a chemical tool for the isolation and protection of living cells from harmful, often lethal, external environments. Although several strategies are available to form nanometric films, most methods heavily rely on time-consuming multistep processes not biocompatible. Here, interfacial supramolecular self-assembly film formation ferric ions (FeIII ) tannic acid (TA) in biphasic systems is reported, where FeIII TA come into contact each other self-assemble across...

Abstract Chemical encapsulation of microbes in threedimensional polymeric microcapsules promises various applications, such as cell therapy and biosensors, provides a basic platform for studying microbial communications. However, the cytoprotection against external aggressors has been major challenge field microencapsulation, because ionotropic hydrogels widely used microencapsulation swell uncontrollably, are physicochemically labile. Herein, we developed simple polydopamine coating...

We have devised a unique method for sensitive and selective detection of Hg2+ ions using DNA-modified gold microshells which can be individually manipulated micropipette act as micro SERS probe analysis in small sample volumes.

Abstract The design of stimuli-responsive self-assembled molecular systems capable undergoing mechanical work is one the most important challenges in synthetic chemistry and materials science. Here we report that foldectures, is, architectures β -peptide foldamers, uniformly align with respect to an applied static magnetic field, also show instantaneous orientational motion a dynamic field. This response explained by amplified anisotropy diamagnetic susceptibilities as result well-ordered...

Parkinson's disease (PD) is a complex neurodegenerative disorder with an unclear etiology. Despite significant research efforts, developing disease-modifying treatments for PD remains major unmet medical need. Notably, drug repositioning becoming increasingly attractive direction in discovery, and computational approaches offer relatively quick resource-saving method identifying testable hypotheses that promote repositioning. We used artificial intelligence (AI)-based strategy to screen...

The blood-type-mismatch problem, in addition to shortage of blood donation, transfusion has prompted the researchers develop universal that does not require typing. In this work, "cell-in-shell" (i.e., artificial spore) approach is utilized shield immune-provoking epitopes on surface red cells (RBCs). Individual RBCs are successfully coated with supramolecular metal-organic coordination complex ferric ion (FeIII) and tannic acid (TA). use isotonic saline (0.85% NaCl) found be critical...

Selectively targeting the endoplasmic reticulum (ER) of cancer cells, though promising a new strategy for therapy, remains underdeveloped. Enzyme-instructed self-assembly (EISA) is emerging as approach selectively ER cells. This work reports an easily accessible branched peptide that consists D-tetrapeptide backbone and branch with sequence KYDKKKKDG (K: lysine; Y: tyrosine; D: aspratic acid; G: glycine), being EISA substrate typsin-1 (PRSS1), inhibits Depending on type level PRSS1...

Hexanuclear, octanuclear, and decanuclear manganese metalladiazamacrocycles have been prepared by reacting a series of pentadentate ligands, N-acylsalicylhydrazides (N-(3-methylbutanoyl)salicylhydrazide (H(3)3-mbshz), N-(phenylacetyl)salicylhydrazide (H(3)pashz), N-(3,3-dimethylbutanoyl)salicylhydrazide (H(3)3-dmbshz), N-(2-methylpropanoyl)salicylhydrazide (H(3)2-mpshz), N-((R,S)-2-methylbutanoyl)salicylhydrazide (H(3)RS-2-mbshz), N-((S)-2-methylbutanoyl)salicylhydrazide (H(3)S-2-mbshz),...

Abstract Background and Aim: The number of patients with ulcerative colitis (UC) in Korea has increased. In addition, the colorectal cancer (CRC) associated UC also Therefore, this population‐based nationwide study was conducted to investigate incidence CRC compare these results those studies other countries. Methods: Korean Association for Study Intestinal Diseases (KASID) reviewed 7061 cases that occurred between 1970 2005 found a total 26 CRC. Results: overall prevalence 0.37%. estimated...

Enzymatic polymerization is utilized for material-independent surface modification. Tyrosinase catalyzes the film formation of various phenolic amines under highly cytocompatible conditions.

One-step fabrication method for thin films and shells is developed with nature-derived eggshell membrane hydrolysates (ESMHs) coffee melanoidins (CMs) that have been discarded as food waste. The polymeric materials, ESMHs CMs, prove highly biocompatible living cells, the one-step enables cytocompatible construction of cell-in-shell nanobiohybrid structures. Nanometric ESMH-CM are formed on individual probiotic Lactobacillus acidophilus, without any noticeable decrease in viability,...

Cu2O has attracted significant attention as a potential photocatalyst for CO2 reduction. However, its practical use is limited by rapid charge recombination, insufficient catalytic sites, and poor stability. In this study, we report facile synthesis of Cu2O@BiOCl core–shell hybrids with well‐defined shape two‐dimensional nanosheet structure BiOCl. The strategic selection BiOCl promotes the separation efficiency via formation interfacial p‐n junction provides active site reduction leading...

Probiotic oral delivery is challenged by harsh gastrointestinal conditions and environmental stressors in the body. This study presents construction of durable nanoshells composed an Fe3+-phytic acid metal-organic complex around individual probiotic cells, providing exceptional cytoprotective properties, single-cell nanoencapsulation. Nanoencapsulated Levilactobacillus brevis maintains high viability under simulated gastric fluid antibiotic tetracycline. The provide effective platform for...

We report on helical coordination networks that were prepared using a hexanuclear manganese metallamacrocycle as tecton. able to prepare the three-dimensional metallamacrocycle, [Mn(6)(lshz)(6)], tecton, where N-lauroyl salicylhydrazide (H(3)lshz) was used primary building unit generate tecton secondary unit. While 4(1)/4(3) screw symmetry-linked network obtained when units had an N-acetyl group, both 3(1)/3(2) and simultaneously in same batch long alkyl group at site.

Abstract Key evidences are reported for the rectification mechanism of an aqueous ion diode based on polyelectrolytic plugs a microfluidic chip by monitoring flow crossing over junction. The penetrating polyelectrolyte junction is visualized employing fluorescent chemodosimeter, rhodamine B hydrazide and pH‐dependent dye, carboxy‐fluorescein. How hysteresis phenomena, exhibited through nonlinear behavior diode, affected variety parameters (e.g., switching potential, scan rate, electrolyte...

Although the programmed degradation of biocompatible films finds applications in various fields including biomedical and bionanotechnological areas, coating methods have generally been limited to be substrate-specific, not applicable any kinds substrates. In this paper, we report a dopamine derivative, which allows for both universal substrates stimuli-responsive film degradation, inspired by mussel-adhesive proteins. Two moieties are linked together disulfide bond, cleavage enables...

One-step assembly of iron(III)–tannic acid (Fe3+–TA) complex forms nanothin (∼10 nm) films on various substrates within minutes. In this deposition scheme, however, the film does not grow continuously over time even though Fe3+–TA is still abundant in coating solution. paper, we report that salt addition dramatically changes one-off characteristic to continuous one, and each has its optimum concentration (CMFT) produces maximum thickness. For detailed investigation effects, employed salts,...