A5101719913- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Pediatric Hepatobiliary Diseases and Treatments
- Esophageal and GI Pathology
- Liver Disease Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Cancer Diagnosis and Treatment
- Biliary and Gastrointestinal Fistulas
- Neutropenia and Cancer Infections
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatitis B Virus Studies
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Hedgehog Signaling Pathway Studies
- Cancer, Hypoxia, and Metabolism
- Hepatitis Viruses Studies and Epidemiology
- Parasite Biology and Host Interactions
- Autophagy in Disease and Therapy
- Renal cell carcinoma treatment
- Cancer Immunotherapy and Biomarkers
- Cancer survivorship and care
- Metastasis and carcinoma case studies
- Inflammatory Biomarkers in Disease Prognosis
- Pancreatitis Pathology and Treatment
- Viral-associated cancers and disorders
Kyung Hee University Medical Center
2020-2025
Kyung Hee University
2019-2025
Korea University
2015-2020
Gyeongsang National University
2012-2019
Gyeongsang National University Hospital
2014-2019
Korea University Medical Center
2015-2019
Creative Commons
2016
Changwon National University
2016
Christie's
2016
Hepatitis B Foundation
2016
Although oxaliplatin is an effective chemotherapeutic drug for colorectal cancer (CRC) treatment, patients often develop resistance to it. Therefore, a new strategy CRC treatment needed. The purpose of this study was determine the effect cannabidiol (CBD), one components cannabis plant, in overcoming cells. We established oxaliplatin-resistant cell lines, DLD-1 R and colo205 R, Autophagic death induced when cells were treated with both CBD. Additionally, phosphorylation nitric oxide synthase...
Abdominal tuberculosis (TB) is an uncommon form of infection with Mycobacterium in Korea. In this study, we aimed to highlight the clinical features, diagnostic methods, and outcomes abdominal TB over 12 years Southeastern Korea.A total 139 patients diagnosed as having who received anti-TB medication from January 2005 June 2016 were reviewed. Among them, 69 (49.6%) had luminal TB, 28 (20.1%) peritoneal 7 (5.0%) nodal 23 (16.5%) visceral (8.6%) mixed TB.The most frequent symptoms pain (34.5%)...
The aim of this study was to evaluate the characteristics and prognostic factors small cell lung cancer (SCLC) with bone metastases. We also investigated predictive skeletal-related events (SREs) in these patients.Sixty-one patients who were first diagnosed SCLC metastases at our institution included retrospective analysis.The overall survival (OS) shorter than that without (4.13 vs. 6.17 months, p = 0.015). Poor Eastern Cooperative Oncology Group (ECOG) performance status (PS; ≥2) higher...
Abstract Despite the improved outcomes in patients with hematological malignancies, infections caused by multidrug-resistant organisms (MDROs) pose a new threat to these patients. We retrospectively reviewed cancer and bacterial bloodstream (BSIs) at tertiary hospital between 2003 2022 assess impact of MDROs on outcomes. Among 328 BSIs, 81 (24.7%) were MDROs. MDRO rates increased from 10.3% (2003–2007) 39.7% (2018–2022) ( P < 0.001). The 30-day mortality rate was 25.0%, which...
Reactive oxygen species modulator-1 (Romo1) is a novel protein that has been reported to be crucial for cancer cell proliferation and invasion. However, its clinical implications in colorectal patients are not well-known. For the first time, we investigated association between Romo1 outcomes of patients.We examined expression resected tumor tissues immunohistochemically assessed it with histological scores. We conducted survival analyses who had curative resection (n = 190) accordance...
Peritoneal carcinomatosis in gastric cancer (GC) patients results extremely poor prognosis. Malignant ascites samples are the most appropriate biological material to use evaluate biomarkers for peritoneal carcinomatosis. This study identified exosomal MicroRNAs (miRNAs) differently expressed between benign liver cirrhosis-associated (LC-ascites) and malignant cancer-associated (GC-ascites), validated their role as diagnostic GC-ascites.Total RNA was extracted from exosomes isolated 165 (73...
Genipin, a major component of Gardenia jasminoides Ellis fruit, has been shown to inhibit the growth gastric, prostate, and breast cancers. However, anti-proliferative activity genipin in colorectal cancer (CRC) not characterized. Herein, we demonstrated that inhibits proliferation CRC cells suppressed Hedgehog pathway. Further investigation showed p53 NOXA protein levels were increased during inhibition pathway-mediated apoptosis cells. We also modulated expression genipin-induced...
This study investigated the prognostic effects of venous thromboembolism (VTE)-related factors in patients with metastatic pancreatic cancer receiving palliative chemotherapy. Predictive for VTE were also investigated.A total 216 diagnosed who received gemcitabine-based chemotherapy at our institution retrospectively evaluated.VTE occurred 51 (23.6%) during treatment and did not affect survival. However, beginning showed poor prognosis compared chemotherapy: all (hazard ratio [HR] 1.897, p =...
Although elevated levels of lactoferrin provide a biomarker for inflammatory bowel diseases and colorectal cancer, the clinical significance these in ascitic fluid patients with ascites caused by liver cirrhosis is limited. The aims our study were to investigate usefulness diagnosis spontaneous bacterial peritonitis (SBP) evaluate association between development hepatocellular carcinoma (HCC).
Reactive oxygen species modulator-1 (Romo1) is a protein that modulates levels of reactive (ROS) and has been reported to affect cancer cell invasion proliferation via persistent inflammation. Several studies have demonstrated the clinical application Romo1 as prognostic marker in non-small lung (NSCLC); however, there no investigating mechanism by which adversely affects prognosis these patients.We examined Romo1, ROS, vascular endothelial growth factor (VEGF) tumor tissues...
Objectives: The primary aim of this study was to investigate the beneficial effect exercise on completion rates adjuvant treatment, which is one major prognostic factors among patients with locally advanced colorectal cancer after undergoing curative resection followed by treatment. Design: Prospective pilot Methods: We assigned who were scheduled undergo treatment (N=39) group or control in a 2:1 ratio order enrollment. Patients completed questionnaires and underwent assessment outcome...
The definition and criteria of radiation-induced hepatic toxicity (RIHT) in hepatocellular carcinoma patients vary among studies. Therefore, the reported rates RIHT differ studies, this causes confusion. In study, we evaluated using several laboratory clinical parameters, analyzed which criterion is more correlated with RT survival. Forty-five HCC treated stereotactic body radiotherapy were included for analysis. All had unresectable Child-Pugh (CP) class A or B baseline liver function....
Although hepatitis C virus (HCV) genotype 3 infection is thought to be an important risk factor for hepatocellular carcinoma (HCC), current evidence limited because only a few Western studies have evaluated the occurrence of HCC in patients with HCV infection. We impact and non-3 on incidence disease progression chronic patients; this first study reporting such findings Asian population. performed retrospective cohort using data 1448 consecutive at three centres Korea between January 2005...
Background/Aims Patients with pancreatic cancer (PC) generally have poor clinical outcomes. Early determination of their prognosis is crucial for developing a therapeutic strategy. Recently, various inflammatory markers been validated as prognostic indicators many cancers, including PC. However, few studies evaluated these together. Thus, the purpose this study was to comprehensively evaluate value in patients advanced PC treated gemcitabine-based chemotherapy first line regimen. Methods...
<b><i>Objectives:</i></b> This study investigated the etiology of acute viral hepatitis and compared clinical features E virus (HEV) infections with those other in Korea. <b><i>Methods:</i></b> included 2,357 consecutive patients who were diagnosed hepatitis, based on illness jaundice or elevated alanine aminotransferase levels (>100 IU/L), between January 2007 2016. Acute observed 23 (19.8%) HEV, 49 (42.2%) A virus, 28 (24.1%) B 16 (13.8%)...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to behave as an attractive anti-cancer agent in various cancers. Despite its promise TRAIL has limitations such short half-life and rapid development of resistance. In this regard, approaches sensitizers that can overcome the are necessary. However, molecular targets mechanisms underlying sensitization TRAIL-induced apoptosis not fully understood. Here, we propose reactive oxygen species modulator-1 (Romo1) sensitizer...