A5075701011- Immune Cell Function and Interaction
- Adenosine and Purinergic Signaling
- interferon and immune responses
- Neuroblastoma Research and Treatments
- Cannabis and Cannabinoid Research
- Autophagy in Disease and Therapy
- Cancer-related Molecular Pathways
- Endoplasmic Reticulum Stress and Disease
- Virus-based gene therapy research
- Cell death mechanisms and regulation
- Ginseng Biological Effects and Applications
- Hedgehog Signaling Pathway Studies
- Echinoderm biology and ecology
- Diet, Metabolism, and Disease
- Flavonoids in Medical Research
- Saffron Plant Research Studies
- Cancer Immunotherapy and Biomarkers
- Medicinal Plants and Bioactive Compounds
- Polyamine Metabolism and Applications
- PARP inhibition in cancer therapy
- PI3K/AKT/mTOR signaling in cancer
- Liver physiology and pathology
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Oral and gingival health research
Korea University
2018-2024
Korea University Medical Center
2019-2020
Palmetto Hematology Oncology
2019
Abstract According to recent studies, Cannabidiol (CBD), one of the main components Cannabis sativa , has anticancer effects in several cancers. However, exact mechanism CBD action is not currently understood. Here, promoted cell death gastric cancer. We suggest that induced apoptosis by suppressing X-linked inhibitor (XIAP), a member IAP protein family. reduced XIAP levels while increasing ubiquitination XIAP. The expression Smac, known XIAP, was found be elevated during treatment....
Although oxaliplatin is an effective chemotherapeutic drug for colorectal cancer (CRC) treatment, patients often develop resistance to it. Therefore, a new strategy CRC treatment needed. The purpose of this study was determine the effect cannabidiol (CBD), one components cannabis plant, in overcoming cells. We established oxaliplatin-resistant cell lines, DLD-1 R and colo205 R, Autophagic death induced when cells were treated with both CBD. Additionally, phosphorylation nitric oxide synthase...
Oxaliplatin is an anticancer drug administered to colorectal cancer (CRC) patients in combination with 5-fluorouracil and antibodies (bevacizumab cetuximab), thereby significantly improving the survival rate of CRC. However, due various side effects associated above treatment strategy, need for combinatorial therapeutic strategies has emerged. Based on demand new therapies known antitumor omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA), we investigated DHA its effect. Our...
Genipin is a compound derived from gardenia fruit extract. Although has anti-tumor effects in various cancers, its effect and mechanism gastric cancer remain unclear. Here, we investigated the relationship between anticancer of signal transducer activator transcription (Stat3)/myeloid cell leukemia-1 (Mcl-1) human cancers.MTT assays were performed to determine viability epithelial lines (AGS, MKN45, SNU638, MKN74, HFE-145). A TUNEL assay Western blotting carried out investigate apoptosis....
A major problem of colorectal cancer (CRC) targeted therapies is relapse caused by drug resistance.In most cases CRC, patients develop resistance to anticancer drugs.Cetuximab does not show many the side effects other drugs and improves survival with metastatic CRC.However, molecular mechanism cetuximab fully understood.Methods: EPHB3-mediated was confirmed in vitro western blotting, colony-forming assays, WST-1 colorimetric assay, vivo xenograft models (n = 7 per group).RNA-seq analysis...
Cannabidiol, a major non-psychotomimetic compound derived from Cannabis sativa, is potential therapeutic agent for variety of diseases such as inflammatory diseases, chronic neurodegenerative and cancers. Here, we found that the combination cannabidiol TNF-related apoptosis-inducing ligand (TRAIL) produces synergistic antitumor effects in vitro. However, this effect was not observed normal colonic cells. The levels ER stress-related proteins, including C/EBP homologous protein (CHOP)...
To assess the effect of Cannabidiol (CBD) on angiogenesis and stemness breast cancer cells as well proliferation. Methods: mRNA level amount protein vascular endothelial growth factor (VEGF) were determined by qRT-PCR ELISA. The angiogenic potential under hypoxic conditions was identified HUVEC tube formation assay. degradation HIF-1α CBD Src/von Hippel-Lindau tumor suppressor (VHL) interaction assessed a co-immunoprecipitation assay Western blotting. identify mamospheres, they evaluated...
Abstract The current treatment for patients with triple negative breast cancer (TNBC) relies on cytotoxic therapy. Currently, atezolizumab and chemotherapy can be combined in TNBC, but this approach is not effective all low reactivity to atezolizumab. As there a lack of alternative options, new anti-cancer drugs are urgently needed enhance against TNBC. Recent strategies have focused regulating the expression programmed death-ligand 1 (PD-L1) or enhancing immune response activation by...
Abstract The treatment of patients with triple-negative breast cancer (TNBC) relies on cytotoxic therapy. Currently, atezolizumab and chemotherapy can be combined in TNBC. However, this approach is not effective for all patients, many tumors showing low responsiveness to atezolizumab. As there a lack alternative options, new anticancer drugs are urgently needed enhance activity against Recent strategies have focused regulating the expression programmed cell death ligand 1 (PD-L1) or...
Natural products have shown great promise in sensitizing cells to TNF-related apoptosis-inducing ligand (TRAIL) therapy. Sea cucumber (SC) extracts possess antitumor activity, and hence their potential sensitize colorectal cancer (CRC) TRAIL therapy was evaluated. This study used Western blotting evaluate the combination effects of SC CRC, determined molecular mechanism underlying these effects. fractions alone did not affect apoptosis; however, combined treatment dramatically induced...
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is known to behave as an attractive anti-cancer agent in various cancers. Despite its promise TRAIL has limitations such short half-life and rapid development of resistance. In this regard, approaches sensitizers that can overcome the are necessary. However, molecular targets mechanisms underlying sensitization TRAIL-induced apoptosis not fully understood. Here, we propose reactive oxygen species modulator-1 (Romo1) sensitizer...
Daunorubicin, also known as daunomycin, is a DNA‑targeting anticancer drug that used chemotherapy, mainly for patients with leukemia. It has been shown to have effects in monotherapy or combination therapy solid tumors, but at present it not adequately studied colorectal cancer (CRC). In the study, from screening using an FDA‑approved library, was found daunorubicin suppresses GLI‑dependent luciferase reporter activity. Daunorubicin increased p53 levels, which contributed both GLI1...
Although the anticancer activity of Korean Red Ginseng (KRG) has been known in various cancers, mechanism KRG-induced apoptosis is unknown colorectal cancer (CRC). In our study, we examined whether KRG induces CRC cells. cell viability assay, concentration appropriate extracts was fixed at 2.5 mg/mL numerous This other experiments, and it confirmed that induce We found induced Noxa activation increased endoplasmic reticulum stress via reactive oxygen species production. indicated efficiently...
<p>Synergistic effects of CBD and anti-PD-L1 mAb in vivo experiments</p>
<div>Abstract<p>The treatment of patients with triple-negative breast cancer (TNBC) relies on cytotoxic therapy. Currently, atezolizumab and chemotherapy can be combined in TNBC. However, this approach is not effective for all patients, many tumors showing low responsiveness to atezolizumab. As there a lack alternative options, new anticancer drugs are urgently needed enhance activity against Recent strategies have focused regulating the expression programmed cell death ligand 1...
<p>CBD regulates immune checkpoint molecules in breast cancer cell lines</p>
<p>CBD-induced PD-L1 expression in murine TNBC cells</p>
<p>CBD induced immunogenic cell death in TNBC cells</p>
<p>The combination of CBD and atezolizumab stimulated an anti-cancer immune response in a co-culture system</p>