A5014626381- Malaria Research and Control
- Sleep and related disorders
- Circadian rhythm and melatonin
- Blood properties and coagulation
- Mosquito-borne diseases and control
- Blood groups and transfusion
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Advanced Biosensing Techniques and Applications
- Erythrocyte Function and Pathophysiology
- Vector-borne infectious diseases
- Sleep and Wakefulness Research
- Blood Coagulation and Thrombosis Mechanisms
- Platelet Disorders and Treatments
- Advanced biosensing and bioanalysis techniques
- Biosensors and Analytical Detection
- Viral gastroenteritis research and epidemiology
- Hemophilia Treatment and Research
- Influenza Virus Research Studies
- Optical Imaging and Spectroscopy Techniques
- Sepsis Diagnosis and Treatment
- Blood transfusion and management
- Respiratory viral infections research
- Parvovirus B19 Infection Studies
- Microfluidic and Bio-sensing Technologies
Kangwon National University Hospital
2006-2024
Korea University
1998-2023
Kangwon National University
2014-2023
Inje University Busan Paik Hospital
2019
Gachon University
2014
Kyungdong University
2009-2010
Hallym University
2007
Korea University Medical Center
2006
Ansan University
2006
Republic of Korea Army
2006
Neutrophils are considered to play a central role in ventilator-induced lung injury (VILI). However, the pulmonary consequences of neutrophil accumulation have not been fully elucidated. Matrix metalloproteinase-9 (MMP-9) had postulated participate transmigration. The purpose this study was investigate MMP-9 neutrophilic inflammation VILI. Male Sprague-Dawley rats were divided into three groups: 1) low tidal volume (LVT), 7 ml/kg (VT); 2) high (HVT), 30 VT; and 3) HVT with MMP inhibitor...
ABSTRACT Activation of the inducible nitric oxide synthase (iNOS)/nitric (NO) pathway in keratinocytes has been reported to be associated with pathogenesis melanogenesis. Akt activation plays an important role transcription factor nuclear (NF)‐κB and subsequent elevation iNOS expression. In present study, we highly detected both protein phosphorylation basal layer epidermis at junction dermis melasma skin biopsy specimens, but not normal tissues, from nine patients using immunohistological...
It is clinically important to be able detect influenza A/H1N1 virus using a fast, portable, and accurate system that has high specificity sensitivity. To achieve this goal, it necessary develop highly specific primer set recognizes only A viral genes rapid real-time PCR can even single copy of the gene. In study, we developed validated novel fluidic chip-type (LabChip PCR) sensitive for detection A/H1N1, including pandemic strain 2009. This LabChip several remarkable features: (1) allows...
Red blood cells (RBCs) from the cord of newborn infants have distinctive functions for fetal and infant development. To systematically investigate biophysical characteristics individual RBCs in infants, a comparative study was performed adult mothers or non-pregnant women, employing optical holographic micro-tomography. Optical measurements 3-D refractive index distributions, dynamic membrane fluctuations RBCs, enabled retrieval morphological, biochemical, mechanical properties cord,...
Abstract Conflicting results have been reported regarding the effectiveness of light treatment (LT) in patients with Alzheimer’s disease (AD). We investigated blue-enriched white LT on sleep, cognition, mood and behavior mild moderate AD. The group (n = 14) sat about 60 cm away from a small (136 × 73 16 mm) LED box for 1 h each morning 2 weeks. control 11) wore dark, blue-attenuating sunglasses during exposures. started 9–10 after individual’s dim melatonin onset (DLMO). Assessments were...
Bacterial infections of the lung are known to induce inflammatory responses, which lead mucus hypersecretion. Moreover, mucin synthesis in airways has been reported be regulated by neutrophilic inflammation-induced epidermal growth factor receptor (EGFR) expression and its activation. Furthermore, matrix metalloproteinases (MMPs), especially MMP-9, have promote transmigration activated neutrophils. In this study, we investigated associations between lipopolysaccharide (LPS)-induced goblet...
Abstract Introduction Poly (ADP-ribose) polymerase (PARP) participates in inflammation by cellular necrosis and the nuclear factor-kappa-B (NF-κB)-dependent transcription. The purpose of this study was to examine roles PARP ventilator-induced lung injury (VILI) normal mice lung. Methods Male C57BL/6 were divided into four groups: sham tracheostomized (sham), lung-protective ventilation (LPV), VILI, VILI with inhibitor PJ34 pretreatment (PJ34+VILI) groups. Mechanical (MV) settings peak...
Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the distribution and antimicrobial resistance of S. isolated between 2014 2016 Korea.We collected a total 1,855 isolates from 44 hospitals May 2016, analyzed serotypes by sequential multiplex PCR. each patient age, source clinical specimen, pattern.The most common were 11A (10.1%), followed 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), 35B (6.2%). The major invasive (12.6%), (7.8%),...
Factor XIII (FXIII), a thrombin-activated plasma transglutaminase zymogen, is involved in cancer development and progression through triggered coagulation pathway. The aim of this study was to examine whether FXIII activity levels differed non-small cell lung (NSCLC) patients according histological types TNM stage when compared with healthy subjects.Twenty-eight NSCLC 28 normal controls who had been individually age-, gender-, body mass index-, smoking status-, amount-matched were enrolled:...
Abstract We evaluated newly developed surrogate virus neutralization tests (sVNT) for detecting neutralizing antibodies (NAbs) against the receptor binding domain of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). VERI-Q SARS-CoV-2 Neutralizing Antibody Detection ELISA Kit (MiCo BioMed, Gyeonggi-do, Republic Korea, hereafter, “eCoV-CN”) is an enzyme-linked immunosorbent assay-based sVNT, and Rapid Test “rCoV-RN”) a point-of-care lateral-flow immunochromatography test with...
A new label-free array system using amide-linked (AL) NHS−dextran and a spectral SPR biosensor are presented for the high-throughput analysis of C-reactive protein (CRP) in human sera. The AL layer on surface gold arrays was composed an amide linkage between NHS-modified carboxymethyl−dextran amine-modified 11-mercaptoundecanoic acid. topology analyzed by atomic force microscopy, it found to be superior previously used epoxide-linked its immobilization proteins. Specific immunoreactions...
Background Rapid influenza diagnostic tests ( RIDT s) show variable sensitivities in clinical settings. We aimed to compare three digital s and one conventional . Methods assessed 218 nasopharyngeal swabs from patients between neonates 90 years old 2016. Three were BUDDI , Sofia Influenza A+B Fluorescence Immunoassay, Veritor System Flu assay. One test was the SD Bioline Ag A/B/A(H1N1/2009). All results compared with those Anyplex A/B Typing Real‐time Detection real‐time PCR The four tested...
Background:We evaluated the clinical performance of [-2]proPSA (p2PSA) and its derivatives in predicting presence aggressiveness prostate cancer (PCa) Korean men.Methods: A total 246 men with prostate-specific antigen (tPSA) ≥ 3.5 ng/mL who underwent their first biopsy were included this prospective, multicenter, observational study.Diagnostic accuracy tPSA, free-to-total PSA ratio (%fPSA), p2PSA, %p2PSA, Beckman Coulter health index (PHI) was assessed by receiver operating characteristic...
We developed a novel on-chip assay using protein arrays for quantitative and rapid analysis of blood coagulation factor XIII (FXIII) activity in human plasma. FXIII is activated by concerted action thrombin Ca2+ plays essential roles hemostasis, angiogenesis, wound healing. fabricated immobilizing fibrinogen onto the 3-aminopropyltrimethoxysilane layer well-type determined analyzing biotinylated with Cy3-conjugated streptavidin. optimal concentrations Ca2+, thrombin,...
Background Due to its great sensitivity, the nucleic acid amplification test ( NAAT ) is widely used for detection of respiratory viruses RV ). However, few reports have described a direct comparison between multiplex RT ‐ PCR assays . The objective this study was perform three viruses. Methods A total 201 samples (161 nasopharyngeal swab and 40 sputum samples) were tested with commercial assays: Seegene Anyplex II 16 AP ), LG AdvanSure AD Biosewoom Real‐Q RQ additional tests discrepant...
We investigated the potential use of a spectral surface plasmon resonance (SPR) biosensor in high-throughput analysis mumps virus and virus-specific mAb on arrays cationic polyelectrolyte, poly(diallyldimethylammonium chloride) (PDDA). The PDDA was constructed by electrostatic adsorption polyelectrolyte onto monolayer 11-mercaptoundecanoic acid (MUA). Poly-L-lysine also adsorbed MUA compared with capacity immobilization. showed higher than poly-L-lysine surface. SPR signal caused binding...
Summary The Cell‐Dyn 4000 automated hematology analyzer (CD4000) has the ability to detect malaria patients, but it remained unclear whether could persistent post‐treatment. To investigate this, we used CD4000 evaluate 68 Korean patients with Plasmodium vivax malaria, and control groups of 50 fever asymptomatic patients. results from instrument‐generated scatter plot (derived by laser light depolarization) were compared microscopy results. During initial diagnosis, sensitivity in detecting...