A5055634522- Urinary Tract Infections Management
- T-cell and B-cell Immunology
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Pediatric Urology and Nephrology Studies
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Antibiotic Resistance in Bacteria
- Immunotherapy and Immune Responses
- Pelvic floor disorders treatments
- Liver Disease Diagnosis and Treatment
- Fungal Infections and Studies
- Antifungal resistance and susceptibility
- Erythrocyte Function and Pathophysiology
- Digital Holography and Microscopy
- Antibiotic Use and Resistance
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Advanced Biosensing Techniques and Applications
- HIV Research and Treatment
- Mycobacterium research and diagnosis
- Bacterial Infections and Vaccines
- Hepatitis Viruses Studies and Epidemiology
- Bacterial Identification and Susceptibility Testing
Eulji University
2013-2023
Eulji University Hospital
2010-2023
Inje University Busan Paik Hospital
2019
University of Ulsan
2005-2011
Asan Medical Center
2005-2011
Ulsan College
2005-2011
Armed Forces Capital Hospital
2007
Dongguk University
2007
In this paper, we present the optical characterisations of diabetic red blood cells (RBCs) in a non-invasive manner employing three-dimensional (3-D) quantitative phase imaging. By measuring 3-D refractive index tomograms and 2-D time-series images, morphological (volume, surface area sphericity), biochemical (haemoglobin concentration content) mechanical (membrane fluctuation) parameters were quantitatively retrieved at individual cell level. With simultaneous measurements properties,...
Several factors contribute to differences in Streptococcus pneumoniae serotype distribution. We investigated the distribution and antimicrobial resistance of S. isolated between 2014 2016 Korea.We collected a total 1,855 isolates from 44 hospitals May 2016, analyzed serotypes by sequential multiplex PCR. each patient age, source clinical specimen, pattern.The most common were 11A (10.1%), followed 19A (8.8%), 3 (8.5%), 34 (8.1%), 23A (7.3%), 35B (6.2%). The major invasive (12.6%), (7.8%),...
We used a Vitek 2 AST-YS08 (YS08) system and the broth microdilution method (BMD) adopted by Clinical Laboratory Standards Institute (CLSI) to compare susceptibility of 184 isolates 11 Candida species fluconazole, voriconazole, micafungin, caspofungin, amphotericin B, flucytosine. In albicans, categorical agreement (CA) was 79.2%, 91.7%, 95.8%, 95.8% for respectively. About 12.5% 4.2% very major errors were detected fluconazole C. glabrata showed excellent essential agreements (EAs) (>90%)...
Single-target rapid antigen tests (RATs) are commonly used to detect highly transmissible respiratory viruses (RVs), such as severe acute syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses. The simultaneous detection of RVs presenting overlapping symptoms is vital in making appropriate decisions about treatment, isolation, resource utilization; however, few studies have evaluated multiplex RATs for SARS-CoV-2 other RVs. We assessed the diagnostic performance targeting both A/B with...
Abstract Context.—Chronic hepatitis B infection is the leading cause of cirrhosis and hepatocellular carcinoma. Human leukocyte antigen may be involved in chronicity virus (HBV) infection. Objective.—To analyze association between HBV human alleles haplotypes 636 organ donors recipients. Design.—Subjects were categorized into 2 groups according to their clinical serologic profiles, specifically, an natural convalescent group chronic carrier (CC) group. Results.—Hepatitis was positively...
Abstract Context.—Chronic hepatitis B infection is the leading cause of cirrhosis and hepatocellular carcinoma. Human leukocyte antigen may be involved in chronicity virus (HBV) infection. Objective.—To analyze association between HBV human alleles haplotypes 636 organ donors recipients. Design.—Subjects were categorized into 2 groups according to their clinical serologic profiles, specifically, an natural convalescent group chronic carrier (CC) group. Results.—Hepatitis was positively...
Major histocompatibility complex (MHC) class I chain‐related gene B ( MICB ) is located within the human MHC region. The location of in region may imply presence linkage disequilibrium with polymorphic MICA and leukocyte antigen (HLA) loci. also polymorphic; however, polymorphisms have not been investigated Koreans. Using sequence‐based typing (SBT), we estimated allelic frequencies haplotypes , HLA‐B HLA‐DRB1 at high resolution a population 139 unrelated Korean individuals. Eight alleles...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human and rapidly transmitted by infected individuals regardless of their symptoms. During COVID-19 pandemic, owing to dearth skilled healthcare workers (HCWs) collect samples for early diagnosis, self-collection emerged as a viable alternative. To evaluate reliability self-collection, we compared virus detection rate using 3990 self-collected swabs HCW-collected swabs, procured from same collected...
Background:The epidemiology of pathogenic bacteria varies according to the socioeconomic status and antimicrobial resistance status.However, longitudinal epidemiological studies evaluate changes in species distribution susceptibility nationwide are lacking.We retrospectively investigated trends over last 20 years Korea.Methods: From 1997 2016, annual cumulative data were collected from 12 university hospitals five provinces four metropolitan cities South Korea.Results: The prevalence...
Major histocompatibility complex (MHC) class I chain-related gene A (MICA) is located within the human MHC, centromeric to HLA-B and telomeric HLA-DRB1. The location of MICA in MHC indicates presence linkage disequilibrium with leukocyte antigen (HLA). Like HLA, highly polymorphic; however, information available for polymorphisms not as comprehensive that HLA polymorphisms. We estimated allelic frequencies haplotypes HLA-DRB1 at high-resolution a population 139 unrelated Korean individuals...
The Abbott RealTime hepatitis C virus (HCV) Genotype II (Abbott Molecular Inc.) for HCV genotyping, which uses real-time PCR technology, has recently been developed.Accuracy and sensitivity of detection were assessed using the RNA PHW202 performance panel (SeraCare Life Sciences). Consistency with restriction fragment mass polymorphism (RFMP) data, cross-reactivity other viruses, ability to detect minor strains in mixtures genotypes 1 2 evaluated clinical samples.All viruses correctly...
This study examined changes in the clinical characteristics of community-acquired acute pyelonephritis (CA-APN) South Korea between period 2010-2011 and 2017-2018. We recruited all CA-APN patients aged ≥19 years who visited eight hospitals from September 2017 to August 2018, prospectively. Data collected were compared with those previous 2010-2012, same design participation 11 hospitals. A total 617 enrolled 818 patients' data 2010-2011. Escherichia coli was most common causative pathogen...
Human leukocyte antigens (HLAs) are useful markers for anthropological investigations because the allele and haplotype distributions at these loci vary widely among ethnic groups. HLA frequencies in Koreans, however, have not previously been analyzed on a phylogenetic basis. We determined of four class II (HLA-DRB1, -DQA1, -DQB1, -DPB1) 149 unrelated Korean individuals using sequence-based typing method. A total 29 HLA-DRB1, 17 HLA-DQA1, 16 HLA-DQB1, 15 HLA-DPB1 alleles were identified. The...
Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, capacity testing systems based on gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contribute prevention community transmission, but their further assessment required. Here, using 1503 nasopharyngeal swabs, we compared diagnostic performance four RAT kits (Abbott Panbio™ COVID-19 Ag Test, SD...
The quality of laboratory test results is crucial for accurate clinical diagnosis and treatment. Pre-analytical errors account approximately 60%-70% all errors. Laboratory may be largely impacted by pre-analytical phase management. However, primary care clinics currently do not have management audit systems. We aimed to understand the current status in medicine Korean clinics.Questionnaires were designed focus on essential components process clinics. An online survey platform was used...
This study aimed to examine the changes in characteristics of community-onset fluoroquinolone-resistant (FQ-R) Escherichia coli isolates causing community-acquired acute pyelonephritis (APN) South Korea.Blood or urine samples were prospectively collected from patients aged ≥15 years with APN who admitted one eight Korean hospitals included this between September 2017 and August 2018. Phylogenetic typing, multilocus sequence molecular characterization β-lactamase resistance plasmid-mediated...
Abstract Microarray technology makes high‐throughput genotyping possible by permitting the simultaneous analysis of large sets genes on a small reaction slide. Human leukocyte antigen (HLA) loci showing high polymorphisms are suitable targets for microarray. In this study, we developed microarray kit with newly designed oligonucleotide probes HLA‐A and ‐DRB1. total, 42 were to hybridize polymorphic sites 36 HLA‐DRB1. Asymmetric polymerase chain (PCR) using four primers was performed amplify...
Hepatitis B virus (HBV) detected in Korean patients almost belongs to genotype C, which is subdivided into subgenotype C1 (or Cs) and C2 Ce). It was recently reported that the risk of hepatocellular carcinoma different between C2. Thus, we studied distribution subgenotypes HBV chronic hepatitis (CHB) patients.Specimens 421 patients, who were diagnosed as CHB underwent antiviral treatment, used. After sequence analysis for S gene, identified through phylogenetic analysis. Utilizing same data,...
The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusion. To systematically investigate changes whole blood, the hematological properties individual RBCs were quantified samples for various periods with without a preservation solution called CPDA-1. With 3-D quantitative phase imaging techniques, optical measurements refractive index (RI) distributions membrane fluctuations done at cell level. From measurements, morphological...
New allele B*4617 showed one nucleotide difference with B*460101 at codon 167 (TGG→TCG).
We investigated hepatitis B virus (HBV) infection cases, who were HBsAg negative by radioimmunoassay (RIA) and HBV DNA positive for their clinical characteristics, the S gene mutation of (HBV), usefulness other immunoassay.Among patients requested quantification, 16 in but RIA (BNIBT Kit, China) enrolled. The "a" determinant was sequenced characteristics reviewed. Additional assay performed using Architect kit (Abbott laboratories, USA) employing chemiluminescent immunoassay method.Eleven...
In this paper we present the optical characterisations of diabetic red blood cells (RBCs) in a non-invasive manner employing three-dimensional (3-D) quantitative phase imaging. By measuring 3-D refractive index tomograms and 2-D time-series images, morphological (volume, surface area sphericity), biochemical (haemoglobin concentration content) mechanical (membrane fluctuation) parameters were quantitatively retrieved at individual cell level. With simultaneous measurements properties,...