A5043369066- Genomic variations and chromosomal abnormalities
- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Advanced biosensing and bioanalysis techniques
- Prenatal Screening and Diagnostics
- Neonatal Health and Biochemistry
- SARS-CoV-2 detection and testing
- Analytical Chemistry and Chromatography
- Blood groups and transfusion
- Immunodeficiency and Autoimmune Disorders
- Microfluidic and Capillary Electrophoresis Applications
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- Orthopedic Infections and Treatments
- Gallbladder and Bile Duct Disorders
- Inflammatory mediators and NSAID effects
- Hemoglobinopathies and Related Disorders
- Microfluidic and Bio-sensing Technologies
- Biosensors and Analytical Detection
- Monoclonal and Polyclonal Antibodies Research
- Meta-analysis and systematic reviews
- Clinical Laboratory Practices and Quality Control
- Erythropoietin and Anemia Treatment
- Iron Metabolism and Disorders
- Genomics and Rare Diseases
Eulji University
2009-2025
Eulji University Hospital
2006-2020
Electronics and Telecommunications Research Institute
2014
Harvard University
2010
Brigham and Women's Hospital
2009-2010
Neonatal jaundice is a very common disease in newborns and can lead to brain damage or death severe cases. Phototherapy with light-emitting diode (LED) arrays widely used as the easiest fastest way relieve newborns, but it has distinct disadvantages such loss of water patient, retina, separation from parents. In this paper, novel light source-based phototherapy for neonatal proposed using textile-based wearable organic (OLED) platform that move flexibly conform curvature human body. The soft...
We have proposed a novel mobile healthcare platform, combining pocket-sized colorimetric reader (13.5 × 6.5 2.5 cm(3)) and commercially available 10-parameter urinalysis paper strips (glucose, protein, glucose, bilirubin, urobilinogen, ketones, nitrite, pH, specific gravity, erythrocytes, leukocytes), capable of sending data with smart phone. The includes multi-detection module, which consists three-chromatic light-emitting diodes, silicon photodiodes poly(methylmethacrylate) (PMMA) optical...
Dried blood spot (DBS) technology is a microsampling alternative to traditional plasma or serum sampling for pharmaco- toxicokinetic evaluation. DBS has been applied diagnostic screening in drug discovery, nonclinical, and clinical settings. We have developed an improved elution protocol involving boiling of spots dried on Whatman filter paper. The purpose this study was compare the quality, purity, quantity DNA isolated from frozen samples DBSs. optimized method extraction estimation paper...
Trace metals play a pivotal role in maintaining normal and healthy physiology due to their various metabolic functions humans. This study was performed identify the association between trace type 2 diabetes mellitus (T2DM) through comparative analysis of serum samples from both controls T2DM patients. Additionally, we aim explore potential connection gender differences concentration The included 103 participants, comprising 53 50 patients, with blood stored at Eulji University Hospital...
Summary Because serum ferritin and transferrin saturation (TS) have a limitation in estimating iron status haemodialysis patients, the reticulocyte haemoglobin content (CHr) has been proposed as new tool. We investigate accuracy of CHr comparison with conventional tests relationship between changes levels after therapy. selected 140 patients receiving rHuEPO intravenous supplementation measured their complete blood count, parameters. Iron deficiency was defined <100 μ g/l and/or TS...
Bloodstains are common evidence in crime scenes, containing significant information, including genetic information. Although efforts have been made to reliably determine the time of incident by analyzing elapsed bloodstain, there has limited success. To identify candidate metabolites bloodstains over time, we prepared bloodstain samples using filter paper and analyzed high-performance liquid chromatography–mass spectrometry (HPLC-MS)/MS a 21-day period. Using Venn diagrams multivariate...
Rheumatoid arthritis (RA) is an autoimmune disease that starts with inflammation of the synovial membrane. Studies have been conducted to develop methods for efficient diagnosis RA and identify mechanisms underlying development. Blood samples can be useful detecting disturbance homeostasis in patients RA. Nanoliquid chromatography-tandem mass spectrometry (LC-MS/MS) proteomics approach analyze blood sample quantify serum proteins.Serum 18 healthy controls were analyzed by LC-MS/MS. Selected...
Abstract BACKGROUND: A primary inhibitor of plasminogen activators, SERPINE1 (serpin peptidase 1, clade E, member also known as activator type 1), is an important regulator in tumorigenesis and highly expressed many cancers. METHODS: Five tag single nucleotide polymorphisms (SNPs) 1 insertion polymorphism within were genotyped 1101 unrelated Korean individuals (a case group 612 patients with gastric cancer a control 489 healthy individuals). Associations susceptibility to diffuse‐type (DGC)...
Approximately 15 patients with partial trisomy 9p involving de novo duplications have been previously described. Here, we present clinical, cytogenetic, FISH and aCGH findings in a patient complex rearrangement the short arm of chromosome 9 an inverted duplication at 9p24→p21.3 deletion 9pter→p24.2. probes generated from BACs selected UCSC genome browser were utilized to verify this rearrangement. It is likely that some described may also be products chromosomal aberrations. This report...
We examined the feasibility of a full-length gene analysis for drug resistance-related genes inhA, katG, rpoB, pncA, rpsL, embB, eis, and gyrA using ion semiconductor next-generation sequencing (NGS) compared results with those obtained from conventional phenotypic susceptibility testing (DST) in multidrug-resistant Mycobacterium tuberculosis (MDR-TB) isolates.We extracted genomic DNA 30 pure MDR-TB isolates antibiotic profiles confirmed by DST isoniazid (INH), rifampin (RIF), ethambutol...
Purpose Rheumatoid arthritis (RA) is an autoimmune disease in which autoantibodies attack the synovial membrane, causing joint inflammation. Blood tests would offer a powerful, minimally invasive method for early diagnosis of RA. However, no reliable biomarkers RA are presently available. The aim to develop by multiple reaction monitoring (MRM)‐based quantification candidate biomarkers. Experimental design Proteomics approaches commonly used identify and verify For discovery RA, SWATH...
Abstract Background : The diagnosis of septic arthritis (SA) relies on synovial analysis and conventional culture. But, these methods lack sensitivity culture is time consuming to establish a definite diagnosis. This study evaluated new multiplex PCR assay which entailed screening for Gram typing identification species using two primer mixes. Methods A total 80 fluid samples from patients with suspected SA were collected. Culture, PCR, 16S rRNA gene performed. Results analytical was 10 1...
PTPRCAP (CD45-AP) is a positive regulator of protein tyrosine phosphatase PTPRC (CD45), which activates Src family kinases implicated in tumorigenesis. Single-nucleotide polymorphism (SNP) rs869736 located at position -309 the promoter was associated with susceptibility to diffuse-type gastric cancer current case-control study. The minor-allele homozygote significantly 2.5-fold increased (P = .0021, n 252), but not intestinal-type .30, 178), versus major-allele homozygote, when comparing...
The novelty of this study resides in a 6”-wafer-level microfabrication protocol for microdevice with fluidic control system the separation circulating tumor cells (CTCs) from human whole blood cells. utilizes lateral magnetophoresis method based on immunomagnetic nanobeads anti-epithelial cell adhesive molecule antibodies that selectively bind to epithelial cancer device consists top polydimethylsiloxane substrate microfluidic and bottom magnetophoretic force generation embedded v-shaped...
It has been found that microRNAs (miRNA) affect rheumatoid arthritis (RA) pathophysiology. This study aimed to identify novel serum exosomal miRNAs related RA disease activity in patients with an inadequate treatment response.The sample population comprised clinical remission (CR) and non-clinical (non-CR) groups of patients. To potent miRNA markers for activity, array qPCR were performed after patient exosomes preparation.Has-miR-1915-3p has-miR-6511b-5p significantly higher the CR group....
A porous membrane filter is one of the key components for sample preparation in lab-on-a-chip applications. However, most membranes reported to date have only been used size-based separation since it difficult provide functionality or improve performance membrane. In this work, as a method functionalize filter, controlling shape pores suggested, and convenient mass-producible fabrication provided. With proposed method, filters with round, conical funnel were successfully fabricated, we...
Summary Approximately 10% of patients with chronic lymphocytic leukaemia (CLL) have a family history the disease or related lymphoproliferative disorder, yet relationship familial CLL to genomic abnormalities has not been characterized in detail. We therefore studied 75 patients, half and sporadic, using high‐resolution array comparative hybridization (CGH), order better define other biological prognostic factors. Our results showed that most common high‐risk deletion CLL, 11q, was...