A5004496807- SARS-CoV-2 detection and testing
- Alzheimer's disease research and treatments
- SARS-CoV-2 and COVID-19 Research
- Respiratory viral infections research
- Dementia and Cognitive Impairment Research
- Pneumonia and Respiratory Infections
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- Nuclear Receptors and Signaling
- COVID-19 Clinical Research Studies
- Bacterial Identification and Susceptibility Testing
- Biosensors and Analytical Detection
- Liver Disease Diagnosis and Treatment
- Fungal Infections and Studies
- Microbial infections and disease research
- Folate and B Vitamins Research
- COVID-19 diagnosis using AI
- Medical Imaging Techniques and Applications
- Pneumocystis jirovecii pneumonia detection and treatment
- Antifungal resistance and susceptibility
Chosun University
2018-2024
Abstract Amyloid-β (Aβ) oligomers are implicated in the onset of Alzheimer’s disease (AD). Herein, quinoline-derived half-curcumin-dioxaborine (Q-OB) fluorescent probe was designed for detecting Aβ by finely tailoring hydrophobicity biannulate donor motifs donor-π-acceptor structure. Q-OB shows a great sensing potency dynamically monitoring oligomerization during amyloid fibrillogenesis vitro. In addition, we applied this strategy to fluorometrically analyze self-assembly kinetics...
Variants in the APOE gene region may explain ethnic differences association of Alzheimer’s disease (AD) with ε4. Ethnic allele frequencies for three SNPs (single nucleotide polymorphisms) were identified and tested 19,398 East Asians (EastA), including Koreans Japanese, 15,836 European ancestry (EuroA) individuals, 4985 African Americans, brain imaging measures cortical atrophy sub-samples EuroAs. Among ε4/ε4 AD risk increased substantially a dose-dependent manner number promoter SNP...
Mycoplasma pneumoniae, a major etiological agent of community-acquired pneumonia, exhibits distinct cyclic epidemic patterns recurring every three to five years. Several cases co-infection with severe acute respiratory syndrome coronavirus 2 have been reported globally, resulting in unfavorable clinical manifestations. This study investigated the epidemiological features recent M. pneumoniae outbreak (May 2019–April 2020) using retrospective data from last Molecular test for macrolide...
Severe acute respiratory syndrome coronavirus (SARS-CoV-2) is highly contagious and causes disease 2019 (COVID-19). Reverse transcription quantitative polymerase chain reaction (RT-qPCR) the most accurate reliable molecular assay to detect active SARS-CoV-2 infection. However, a rapid increase in test subjects has created global bottleneck testing capacity. Given that efficient nucleic acid extraction greatly affects results, we compared three platforms: MagNA Pure 96 DNA Viral NA Small...
Classification of clinical symptoms and diagnostic microbiology are essential to effectively employ antimicrobial therapy for lower respiratory tract infections (LRTIs) in a timely manner. Empirical antibiotic treatment without microbial identification hinders the selective use narrow-spectrum antibiotics effective patient treatment. Thus, development rapid accurate procedures that can be readily adopted by clinic is necessary minimize non-essential or excessive accelerate recovery from...
Abstract Background Given that tau accumulation, not amyloid-β (Aβ) burden, is more closely connected with cognitive impairment in Alzheimer’s disease (AD), a detailed understanding of the tau-related characteristics function critical both clinical and research settings. We investigated association between phosphorylated (p-Tau) level across AD continuum mediating role medial temporal lobe (MTL) atrophy. also developed prediction model for abnormal accumulation. Methods included participants...
Single-target rapid antigen tests (RATs) are commonly used to detect highly transmissible respiratory viruses (RVs), such as severe acute syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses. The simultaneous detection of RVs presenting overlapping symptoms is vital in making appropriate decisions about treatment, isolation, resource utilization; however, few studies have evaluated multiplex RATs for SARS-CoV-2 other RVs. We assessed the diagnostic performance targeting both A/B with...
Novel strains of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) harboring nucleotide changes (mutations) in the spike gene have emerged and are spreading rapidly. These mutations associated with SARS-CoV-2 transmissibility, virulence, or resistance to some neutralizing antibodies. Thus, accurate detection mutants is crucial for controlling transmission identifying antibody-resistance caused by amino acid receptor-binding domain. Here, we developed five primer pairs (5-SSG...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the third highly pathogenic human and rapidly transmitted by infected individuals regardless of their symptoms. During COVID-19 pandemic, owing to dearth skilled healthcare workers (HCWs) collect samples for early diagnosis, self-collection emerged as a viable alternative. To evaluate reliability self-collection, we compared virus detection rate using 3990 self-collected swabs HCW-collected swabs, procured from same collected...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggers disease with nonspecific symptoms that overlap those of infections caused by other seasonal viruses (RVs), such as the influenza virus (Flu) or syncytial (RSV). A molecular assay for accurate and rapid detection RV SARS-CoV-2 is crucial to manage these infections. Here, we compared analytical performance clinical reliability Allplex™ SARS-CoV-2/FluA/FluB/RSV (SC2FabR; Seegene Inc., Seoul, South Korea) kit four commercially...
Background: Cerebrospinal fluid (CSF) amyloid-β 1-42 (Aβ ), total tau protein (t-Tau), and phosphorylated Tau (p-Tau) are ATN biomarkers for Alzheimer’s disease (AD) reflect pathogenic changes in the brain. CSF of AD considered inclusion diagnostic criteria research clinical purposes to reduce uncertainty diagnosis distinguish among stages. Objective: This study aims compare two commercially available analytical platforms with respect accuracy potential early AD. Methods: A 211 samples from...
Owing to the high transmissibility of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, capacity testing systems based on gold standard real-time reverse transcription–polymerase chain reaction (rRT-PCR) is limited. Rapid antigen tests (RATs) can substantially contribute prevention community transmission, but their further assessment required. Here, using 1503 nasopharyngeal swabs, we compared diagnostic performance four RAT kits (Abbott Panbio™ COVID-19 Ag Test, SD...
Infectious diseases caused by fungal sources are of great interest owing to their increasing prevalence. Invasive infections, including invasive pulmonary aspergillosis Aspergillus fumigatus, and Pneumocystis pneumonia jirovecii, significant causes morbidity mortality among immunocompromised patients. The accurate timely detection these pathogens in this high-risk population is crucial for effective patient management. We developed a multiplex real-time polymerase chain reaction (PCR) assay,...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes disease 2019 (COVID-19), is still rapidly spreading as of March 2022. An accurate and rapid molecular diagnosis essential to determine the exact number confirmed cases. Currently, viral transport medium (VTM) required for testing in short supply due a sharp increase laboratory tests performed, alternative VTMs are needed alleviate shortage. Guanidine thiocyanate-based media reportedly inactivate SARS-CoV-2 compatible...
Abstract Amyloid-β oligomers ( o Aβ) are implicated in the onset of Alzheimer’s disease (AD). Herein, quinoline-derived half-curcumin-dioxaborine Q-OB ), a highly selective and sensitive fluorescent probe, was designed for detecting Aβ by finely tailoring amphiphilicity biannulate donor motifs D-π-A structure. shows great sensing potency dynamically monitoring during amyloid fibrillogenesis vitro vivo . For first time, we applied this strategy to fluorometrically analyze self-assembly...
Abstract Background The hypothetical concept of cognitive reserve (CR) has been proposed to explain why someone can manage function normally even in the presence brain pathology. However, it still remains be determined what components constitute such resilience against Alzheimer’s disease (AD) In current study we investigated characteristics cognitively normal (CN) elders with high CR. Method We included CN participants from Gwangju Disease and Related Dementia Cohort Korea. selected a group...
Although coronavirus disease 2019 (COVID-19) is no longer a Public Health Emergency of International Concern (PHEIC), severe acute respiratory syndrome 2 (SARS-CoV-2) infection has had vast impact to date. Hence, continuous management required, given the uncertainty caused by potential evolution SARS-CoV-2. Reverse transcription-quantitative PCR (RT-qPCR) diagnosis been fundamental in overcoming this issue. In study, performances two rapid RT-qPCR assays (Real-Q Direct SARS-CoV-2 Detection...
The apolipoprotein E e4 allele (APOE e4) is the most common genetic risk factor for Alzheimer's disease (AD). Even though several studies have reported effect of APOE on onset AD, differential effects ε4 among ethnic groups remains unclear. aim our study to analyse in East Asian populations and investigate AD brain atrophy between different groups. includes 2272 normal subjects 2074 patients from population (1145 786 Korean population, 985 1001 Japanese population), 6262 controls 5107...
The apolipoprotein E e4 allele (APOE e4) is the most potent genetic risk factor for Alzheimer's disease (AD). Although several studies have reported effect of APOE on onset AD, it remains unclear how different among ethnic groups. aim our study to analyse in East Asian populations and investigate AD brain atrophy between includes 17,096 normal subjects 2302 patients from population (16,125 1,308 Korean population, 971 994 Japanese population), 7,417 controls 8,419 Caucasian 3,462 1,523...