A5069858175- Respiratory viral infections research
- Virology and Viral Diseases
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Immunotherapy and Immune Responses
- SARS-CoV-2 and COVID-19 Research
Korea Disease Control and Prevention Agency
2023-2024
Korea National Institute of Health
2023-2024
Nipah virus (NiV), of the Paramyxoviridae family, causes highly fatal infections in humans and is associated with severe neurological respiratory diseases. Currently, no commercial vaccine available for human use. Here, eight structure-based mammalian-expressed recombinant proteins harboring NiV surface proteins, fusion glycoprotein (F), major attachment (G) were produced. Specifically, prefusion NiV-F and/or NiV-G glycoproteins expressed monomeric, multimeric (trimeric F tetra G), or...
The immunogenicity of a heterologous vaccination regimen consisting ChAdOx1 nCoV-19 (a chimpanzee adenovirus-vectored vaccine) followed by mRNA-1273 lipid-nanoparticle-encapsulated mRNA-based against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically the omicron variant (B.1.1.529), is poorly studied. aim this study was to evaluate neutralizing antibody activity and prime-boost wild-type (BetaCoV/Korea/KCDC03/2020), alpha, beta, gamma, delta, variants SARS-CoV-2 in...