A5100327057- Gastrointestinal disorders and treatments
- Eicosanoids and Hypertension Pharmacology
- Pneumonia and Respiratory Infections
- Gastrointestinal Tumor Research and Treatment
- Respiratory viral infections research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Fatty Acid Research and Health
- Aquaculture Nutrition and Growth
- Liver Disease Diagnosis and Treatment
- Bacterial Infections and Vaccines
- Peroxisome Proliferator-Activated Receptors
- Congenital Heart Disease Studies
- Escherichia coli research studies
- Gastrointestinal motility and disorders
- Probiotics and Fermented Foods
- Microbial Metabolic Engineering and Bioproduction
- Medical Research and Treatments
- Enzyme Catalysis and Immobilization
- Gastroesophageal reflux and treatments
- Helicobacter pylori-related gastroenterology studies
- Gut microbiota and health
- Fish Biology and Ecology Studies
- Immune cells in cancer
- Immune Response and Inflammation
- Sinusitis and nasal conditions
Catholic University of Korea
1998-2025
Incheon St. Mary's Hospital
2022-2025
Konkuk University
2020-2025
Sungkyunkwan University
2023-2025
Chonnam National University
2010-2024
Konkuk University Medical Center
2021-2024
Dalian Medical University
2024
Yonsei University
2023
Samsung Medical Center
2022-2023
Hallym University Dongtan Sacred Heart Hospital
2014-2023
Objective Transmissibility of COVID-19 by children in the household is not clear. Herein, we describe children’s role transmission COVID-19. Design and setting All paediatric index cases their members reported from 20 January to 6 April 2020 South Korea were reviewed. The secondary attack rate (SAR) child case was calculated. Epidemiological clinical findings case-household pair assessed. Results A total 107 248 identified. One index-secondary identified, giving a SAR 0.5% (95% CI 0.0%...
Between January 24th and March 10th, a total of 2,370 individuals had contact with the first 30 cases COVID-19. There were 13 who contracted COVID-19 resulting in secondary attack rate 0.55% (95% CI 0.31-0.96). 119 household contacts, which 9 developed 7.56% 3.7-14.26).
Pulmonary valve replacement (PVR) is performed to reduce right ventricular (RV) volume overload, resulting in improved function and clinical status. Significant pulmonary regurgitation (PR) after tetralogy of Fallot (TOF) repair could result RV dysfunction, exercise intolerance, arrhythmia sudden death. The present study was conducted investigate the mid-term outcomes PVR TOF repair. Between 2001 2010, we retrospectively reviewed 131 (89 males 42 females) PVRs with PR or steno-insufficiency...
In this pandemic situation caused by a novel coronavirus disease in 2019 (COVID-19), an electronic support system that can rapidly and accurately perform epidemic investigations, is needed. It would systematically secure analyze patients' data (who have been confirmed to the infection), location information, credit card usage.The "Infectious Disease Prevention Control Act" South Korea, established legal basis for securement, handling procedure, disclosure of information required...
Headache attributed to rhinosinusitis (HRS) is relatively uncommon in pediatric patients and frequently misdiagnosed as a primary headache disorder. This study was conducted identify the clinical characteristics of HRS [bacterial (BRS) non-BRS] determine appropriate treatment headaches. The medical records 1,777 individuals who exhibited underwent neuroimaging studies at two institutions between January 2014 December 2023 were retrospectively reviewed. Of patients, 203 (11.3%) diagnosed with...
ABSTRACT Resolvin E2 (RvE2), 5 S ,18 R ‐dihydroxyeicosapentaenoic acid (5 R‐ DiHEPE), and 18 ‐RvE2 ‐DiHEPE) are specialized pro‐resolving mediators that function in the resolution of inflammation. These SPMs have been produced trace amounts from eicosapentaenoic (EPA) using acetylated cyclooxygenase‐2 or cytochrome P450 5‐lipoxygenase (5‐LOX) via ‐ ‐hydroxyeicosapentaenoic (18 ‐HEPE) intermediates. In this study, we engineered 15 ‐LOX Sorangium cellulosum Archangium violaceum into...
Background Patients who undergo noncardiac surgery shortly after percutaneous coronary intervention (PCI) experience higher rates of perioperative ischemic events, but delaying may affect disease staging and influence cancer recurrence. We aimed to evaluate the association between time from PCI cardiovascular oncologic outcomes in patients with early‐stage cancer. Methods Results included a history underwent (N=3621). The were divided into 2 groups based on dates (<12 ≥12 months). also...
ABSTRACT This article identifies novel factors involved in cholesterol reduction by probiotic bacteria, which were identified using genetic and proteomic approaches. Approximately 600 Lactobacillus acidophilus A4 mutants created random mutagenesis. The cholesterol-reducing ability of each mutant was determined verified two different methods: the o -phthalaldehyde assay gas chromatographic analysis (GC). Among screened mutants, strain BA9 showed a dramatically diminished to reduce...
We investigated changes in gene expression that occur chronic obstructive pulmonary disease (COPD) after corticosteroid treatment and sought to identify the mechanisms regulate these changes. Biopsy samples were taken from patients with COPD (Global Initiative for Chronic Obstructive Lung Disease stage I II) before fluticasone propionate (FP)/salmeterol (SM) (50/500, 4 wk). Gene was measured by microarray confirmed real-time reverse transcription-quantitative PCR (RT-qPCR). The effect of FP...
Abstract Background Social and hospital environmental factors that may be associated with hospital-acquired pneumonia (HAP) have not been evaluated. Comprehensive risk assessment for the incidence of HAP including sociodemographic, clinical, was conducted using national health insurance claims data. Methods This is a population-based retrospective cohort study adult patients who were hospitalized more than 3 days from Health Insurance Review Assessment Service-National Inpatient Sample data...
The purpose of this study was to compare the outcomes lateral tunnel (LT) and extracardiac conduit (ECC) Fontan procedures at a single institution. From April 1995 December 2006, 165 were performed (67 LT, 98 ECC). Pre-, intra- postoperative variable values compared between two different techniques. Operative mortality 5 (3 2 Immediate transpulmonary gradient (LT 8.5±ECC 2.5 vs. 6.6±2.4 mmHg) central venous pressure 18.3±3.8 ECC 15.6±2.4 showed significant difference (P<0.001). LT patients...
A new live attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) has been developed based on innovative technology to give protection against JE with an improved immunogenicity and safety profile. In this phase 3, observer-blind study, 274 children aged 12-24 months were randomized 1:1 receive one dose of JE-CV (Group JE-CV) or the SA14-14-2 currently used vaccinate in Republic Korea SA14-14-2). neutralizing antibody titers assessed using PRNT50 before 28 days after vaccination....
We aimed to compare the antipyretic efficacy, safety, and tolerability between oral dexibuprofen intravenous propacetamol in children with upper respiratory tract infection (URTI) presenting fever. Patients aging from 6 months 14 years admitted for URTI axillary body temperature ≥ 38.0 °C were enrolled randomized into study or control group. group intravenously infused subsequently placebo medication was administered. 100 mL of 0.9% sodium chloride solution without then checked all patients...
Small intestinal bacterial overgrowth (SIBO) is defined as the presence of an excessive number bacteria within small bowel. Pediatric SIBO a heterogeneous disorder that manifests various symptoms ranging from mild gastrointestinal to malabsorption or malnutrition. The carbohydrate breath test commonly used, safe, and noninvasive diagnostic test; however, standardized methodology lacking. Multiple factors, such neuromuscular disorders, systemic diseases, chronic drug use, altered anatomy...
Purpose Gaucher disease is caused by a β-glucocerebrosidase (GBA) deficiency. The aim of this study to investigate the clinical and genetic characteristics according subtypes in Korean population. Methods Clinical findings at diagnosis, GBA mutations, courses were reviewed 20 patients diagnosed with disease. Results Eleven non-neuronopathic type, 2 acute neuronopathic 7 chronic type. Most presented hepatosplenomegaly, thrombocytopenia, short stature. In group, variable neurological features,...
Modified endoscopic mucosal resection (EMR) is considered a treatment option for rectal neuroendocrine tumors (NETs) <10 mm in diameter. In this study, we evaluated the clinical outcomes of cap-assisted EMR (EMR-C) and with ligating device (EMR-L).We retrospectively analyzed 158 patients 162 NETs treated endoscopically at single Korean tertiary hospital between March 2010 November 2017. We rates en bloc resection, histologic complete procedural complications according to method.Among NETs,...
Leukotrienes (LTs) and maresins (MaRs) are human lipid mediators (LMs) involved in immune response anti-inflammation, respectively. These compounds their isomers generated trace amounts by lipoxygenases (LOXs) macrophages neutrophils. LMs have been synthesized using nonenvironmentally benign synthetic protocols, which expensive. 8S- 15S-LOXs with double dioxygenating activities previously reported, whereas 12S-LOX activity not reported to date. Here, we discovered a wild-type from the...
Background. A substantial percentage of patients with ulcerative colitis (UC) have irritable bowel syndrome- (IBS-) like symptoms despite adequate treatment and endoscopic remission. In this study, we evaluated the clinical efficacy probiotic therapy for residual IBS-like in UC Methods. We conducted a multicenter, observational study between April 2018 December 2020 across two university hospitals Korea. Patients whose persisted during remission were included study. Endoscopic was defined as...
Phthalate esters as plasticizers have been widespread in the environment and may be associated with development of allergic diseases such asthma atopic dermatitis. In this study, we demonstrated that CTB glycoprotein attenuates reactions caused by di(2-ethylhexyl) phthalate (DEHP) human mast cells (HMC-1). This experiment evaluated degranulation histamine β-hexosaminidase well activities protein kinase C (PKC), stress-activated kinase/c-Jun N-terminal (SAPK/JNK), activator (AP)-1 interleukin...
Bisphenol A (BPA) is one of the estrogen mimic environmental hormones and a chemical used for wrapping foods, toy products children, biomedical equipment, machines. It can exert toxic effects, such as occurring allergy-related diseases. This study demonstrates that glycoprotein isolated from Rhus verniciflua Stokes (RVS glycoprotein) has an inhibitory activity T-helper type 2 (Th2) cytokines [Interleukin (IL)-4 -10]. First, it was shown RVS inhibits proliferation lymphocytes scavenges...