Functional dyspepsia (FD) is characterized as chronic recurrent upper gastrointestinal symptoms in the absence of any organic disorder. We hypothesized that duodenal low-grade inflammation activates superficial afferent nerve sprouting, thereby contributing to hypersensitivity patients with FD.A prospective case-control study was conducted a tertiary referral center. FD defined using Rome III criteria. Standardized endoscopic biopsies were performed stomach and duodenum. Hematoxylin eosin...

The therapeutic potential of tonsil-derived mesenchymal stem cells (TMSC) prepared from human tonsillar tissue has been studied in animal models for several diseases such as hepatic injury, hypoparathyroidism, diabetes and muscle dystrophy. In this study, we examined the effects TMSC a dextran sulfate sodium (DSS)-induced colitis model. were injected DSS-induced mice via intraperitoneal injection twice (TMSC[x2]) or four times (TMSC[x4]). Control with either phosphate-buffered saline...

Background This study investigated the prognostic value of diffuse splenic uptake on F-18 fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed (CT) in gastric cancer (GC) patients. Methods A total 134 pathology confirmed GC patients who underwent PET/CT for staging work-ups were enrolled. The maximal standardized (SUVmax) primary tumor (Tmax), spleen (Smax), and to liver ratio (SLR) measured. PET-measured parameters predicting recurrence-free survival (RFS) overall (OS)...

Background/Aims The onset of inflammatory bowel disease (IBD) usually occurs at young age, and therefore, women IBD patients experience pregnancy during their progression. Recently, the use anti-tumor necrosis factor-α (anti-TNF-α) has been rapidly increasing. aim this study was to evaluate related outcomes in with who were treated anti-TNF-α immunity children. Methods Korean had enrolled. Medical records reviewed a survey performed for each patient. For agreed on additional examination...

The feasibility of expanding the indications for endoscopic submucosal dissection to treat early gastric cancer based on long-term outcomes has shown conflicting results. This study aimed investigate whether or adverse events associated with are comparable those surgery that including absolute and expanded indications. Data 159 cancers from 153 patients treated between January 2004 October 2014 were reviewed retrospectively. Early fulfilled differentiated type adenocarcinoma included. group...

Rifaximin, a poorly absorbed antibiotics, has gut-specific therapeutic effects. Although frequently prescribed to manipulate intestinal luminal bacterial population in various diseases, the possible induction of antibacterial cross-resistance target pathogen is major concern long-term rifaximin administration. We aimed evaluate whether rifampin-resistant staphylococci could evolve after treatment cirrhotic patients.A total 25 patients who were administered for prevention hepatic...

Background/Aims The Crohn's and Colitis Knowledge (CCKNOW) score does not reflect updated knowledge relating to inflammatory bowel disease (IBD). aim of this study was develop, validate, apply a novel tool measure disease-related in IBD patients. Methods A questionnaire composed 24 items regarding developed: Inflammatory Bowel Disease (IBD-KNOW). Discriminate ability IBD-KNOW validated three occupational groups (14 doctors, 20 nurses, 19 clerks). CCKNOW were administered Factors affecting...

The eradication rate of Helicobacter pylori (H. pylori) with triple therapy which was considered as standard first-line treatment has decreased to 70-85%. aim this study is compare 7-day versus 10-day sequential the first line treatment.Data 1240 H. positive patients treated or from January 2013 December 2015 were analyzed retrospectively. who had undertaken previous gastric surgery excluded.There 872 (74.3%) in group, and 302 (25.7%) group. There no significant difference between two groups...

While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether attenuates apoptosis gentamicin (GM)-induced kidney injury. We investigated on apoptotic pathways rat kidneys damaged by GM. Rats were randomly divided into three groups: 1) Control group (n=8), where only vehicle was delivered, 2) GM (n=10), rats treated with (150 mg/kg/day) for 7 days, 3) PARI co-treated (0.2 µg/kg/day) and days. Paricalcitol attenuated renal...

This study examined priming effects of age stereotypes on memory Korean older adults. Age refer to general beliefs about Through a task, participants were briefly exposed positive or negative without awareness. Before and after the free‐recall tasks given measure their performance. Changes in performance caused by task estimated as stereotypes. Participants showed better they during (positive effects). In contrast, worse (negative The magnitude was similar result suggests that implicit...

Tonsil-derived mesenchymal stem cells (TMSC) have characteristics of MSC and many advantages. In our previous studies, intraperitoneal (IP) injection TMSC in acute chronic colitis mouse models improved the disease activity index, colon length, expression levels proinflammatory cytokines. However, were not observed to migrate inflammation site intestine. The aim this study was verify therapeutic effect conditioned medium (CM) released by (TMSC-CM) a model dextran sulfate sodium (DSS)-induced...

We aimed to report on the clinical outcomes of scleral lens applications in Korean patients with various corneal disorders.This retrospective review was conducted for 62 eyes 47 who had been fitted lenses disorders. The were referred inadequate spectacle-corrected visual acuity and rigid gas permeable (RGP) or soft contact intolerance. Uncorrected acuity, habitually corrected best lens-corrected topographic indices, keratometry parameters evaluated.Twenty-six 19 keratoconus enrolled. Other...

Objective: Inflammatory bowel disease (IBD) usually develops at a young age, and many women experience marriage, pregnancy, delivery during the course. We aimed to evaluate pregnancy-related knowledge of with IBD in Korea investigate associated factors.Material methods: A total 270 IBD, aged 19–45 years, from four tertiary hospitals were administered questionnaire comprising 17 questions validated Crohn's Colitis Pregnancy Knowledge Score (CCPKnow) that translated into Korean.Results: The...

Mesenchymal stem cells (MSCs) are multipotent progenitor currently under investigation for its efficacy as the treatment inflammatory bowel disease. In this study, we evaluated of tonsil-derived mesenchymal (T-MSCs) a novel source and traced their localization in murine model acute colitis induced by dextran sulfate sodium (DSS).C57BL/6 mice were randomly assigned to following three groups: normal control group, DSS group (DSS+phosphate buffered saline), T-MSC (DSS+T-MSCs, 1×106). The...

Although medical and endoscopic hemostasis is now considered as the first-line therapy for nonvariceal upper gastrointestinal (UGI) bleeding, refractory bleeding still occurs in 5%-10% of patients. In these patients, transcatheter arterial embolization (TAE) or surgery required, but research on unmanageable UGI Korea scanty. We reviewed records 518 patients who underwent during 4 years. Among subjects, 8 required due to failure were enrolled. Mean patient age was 74.00 ± 8.25 years,...

18F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) scan is used to evaluate various kinds of tumors. While most studies on PET findings the colon focus colonic uptake pattern, regarding background are rare. The purpose this study was identify association between and presence colorectal adenoma (CRA), which a frequent precancerous lesion. We retrospectively reviewed medical records 241 patients with gynecologic malignancy who had received or PET/computed (CT) colonoscopy at...

To investigate phasic changes during filling cystometry that most accurately represent detrusor properties, regardless of other factors affecting contractility.Seventy-eight patients (59 males, 19 females; mean age, 48.2 years) with spinal cord injuries were enrolled. Urodynamic studies performed using a normal saline rate 24 mL/min. We calculated bladder compliance values the muscle in each three phase intervals, which divided cystometrogram into phases referable to cystometric capacity or...

Neisseria cinerea is bacteria known as non-pathogenic strain. However, in rare cases, it can cause opportunistic infections. Those diseases caused by N. include neonatal ophthalmia, proctitis, pneumonia, peritonitis patients with continuous ambulatory peritoneal dialysis, endocarditis and meningitis. In this report, we describe a patient septic arthritis skin abscess of finger joints that was cinerea. A 27-year-old man visited the hospital due to swelling, redness pain proximal...

Neisseria cinerea is an oropharyngeal normal flora known as a non-pathogenic gram-negative diplococcus. Encephalo-meningitis related to N. very rare. A 15-year-old healthy male visited emergency room for altered mentality with fever, headache, and vomiting. Physical examination showed abdominal tenderness neck stiffness but there was no skin rash. Cerebrospinal fluid (CSF) revealed opening pressure of 210 mmH2O, red blood cell 200/mm3, white 8,320/mm3, neutrophil 84%, glucose 34 mg/dL,...

Post-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims evaluate the effects gut regulatory hormones on post-operative subtotal gastrectomy for cancer.This prospective was conducted 12 months post-surgery 14 controls 13 who underwent cancer. Serum plasma ghrelin, glucagon-like peptide-1, inhibitory peptide YY, insulin, homeostatic model assessment insulin resistance responses standardized test meal were recorded at...

Eosinophilic gastroenteritis is a rare, benign condition, characterized by various gastrointestinal symptoms associated with eosinophilic infiltration of the wall any part digestive tract, most commonly stomach and small intestine. generally classified according to involved layer tract. Serosal type rarest form that characteristically accompanied ascites responds well steroid treatment. We have experienced typical case serosal in women who complained abdominal pain. She had peripheral...

Purpose We report a case of intraocular involvement in diffuse large B-cell lymphoma masquerading as Vogt-Koyanagi-Harada disease.Methods A 48-year-old woman presented with blurred vision both eyes, fever, and hearing disturbance underwent complete ophthalmologic systemic evaluation.Results Ophthalmologic examination showed bilateral exudative retinal detachment signs disease. However, considering her generalized symptoms, evaluation was performed before administering steroid pulse therapy....

Background/Aims: Appropriate sedation during endoscopy can significantly reduce the discomfort experienced by a patient when procedure is performed; however, it associated with several potential risks.Very few reports describe sedation-related adverse events occurring endoscopy.Our study evaluated current status of diagnostic upper endoscopy.Materials and Methods: We reviewed medical records 5,564 cases performed using midazolam for at Ewha Womans University, Mokdong Hospital, between...

Background/Aims Percutaneous endoscopic gastrostomy (PEG) is a widely used method for long-term tube feeding. This study aimed to investigate the clinical characteristics and outcomes of patients who utilized feeding via PEG. Methods The medical records 137 underwent PEG insertion at Ewha Womans University Mokdong Hospital between January 2002 December 2013 were reviewed. Results was indicated most frequently cerebrovascular accidents (66 patients, 48.2%), followed by head neck cancer (20...